6SFG

CRYSTAL STRUCTURE OF DHQ1 FROM SALMONELLA TYPHI COVALENTLY MODIFIED BY COMPOUND 9

Summary for 6SFG

Entry DOI	10.2210/pdb6sfg/pdb
Descriptor	3-dehydroquinate dehydratase, (1~{R},3~{S},4~{R},5~{R})-3-methyl-4,5-bis(hydroxyl)cyclohexane-1-carboxylic acid, (1~{S},3~{R},4~{S},5~{R})-3-methyl-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic Acid, ... (4 entities in total)
Functional Keywords	lyase activity, chorismate biosynthetic process, 3-dehydroquinase, covalent inhibitor, lyase
Biological source	Salmonella typhi
Total number of polymer chains	1
Total formula weight	28045.38
Authors	Sanz-Gaitero, M.,Lence, E.,Maneiro, M.,Thompson, R.,Hawkins, A.R.,Gonzalez-Bello, C.,van Raaij, M.J. (deposition date: 2019-08-01, release date: 2020-04-15, Last modification date: 2024-01-24)
Primary citation	Lence, E.,Maneiro, M.,Sanz-Gaitero, M.,van Raaij, M.J.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C. Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product. Chemistry, 26:8035-8044, 2020 Cited by PubMed: 32259333 DOI: 10.1002/chem.202000759 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.23 Å)

Structure validation