8UUG
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![BU of 8uug by Molmil](/molmil-images/mine/8uug) | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12303 | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | Deposit date: | 2023-11-01 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UUF
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![BU of 8uuf by Molmil](/molmil-images/mine/8uuf) | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun11941 | Descriptor: | ACETATE ION, CHLORIDE ION, N-{(1R)-1-[(3M,5P)-3,5-bis(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-5-[2-(dimethylamino)ethoxy]-2-methylbenzamide, ... | Authors: | Ansari, A, Tan, B, Riuz, F.X, Arnold, E, Wang, J. | Deposit date: | 2023-11-01 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UUE
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![BU of 8uue by Molmil](/molmil-images/mine/8uue) | |
8UUB
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![BU of 8uub by Molmil](/molmil-images/mine/8uub) | Structure of hypothiocyanous acid reductase (Har) from Streptococcus pneumoniae | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, Oxidoreductase, ... | Authors: | Shearer, H.L, Currie, M.J, Dickerhof, N, Dobson, R.C.J. | Deposit date: | 2023-10-31 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae. J.Biol.Chem., 300, 2024
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8UUA
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![BU of 8uua by Molmil](/molmil-images/mine/8uua) | Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III) | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, GTPase HflX, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU9
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![BU of 8uu9 by Molmil](/molmil-images/mine/8uu9) | Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU8
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![BU of 8uu8 by Molmil](/molmil-images/mine/8uu8) | Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU7
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![BU of 8uu7 by Molmil](/molmil-images/mine/8uu7) | Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU6
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![BU of 8uu6 by Molmil](/molmil-images/mine/8uu6) | Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU5
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![BU of 8uu5 by Molmil](/molmil-images/mine/8uu5) | Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UU4
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![BU of 8uu4 by Molmil](/molmil-images/mine/8uu4) | Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Seely, S.M, Basu, R.S, Gagnon, M.G. | Deposit date: | 2023-10-31 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanistic insights into the alternative ribosome recycling by HflXr. Nucleic Acids Res., 52, 2024
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8UTY
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![BU of 8uty by Molmil](/molmil-images/mine/8uty) | KIF1A[1-393] P364L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTX
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![BU of 8utx by Molmil](/molmil-images/mine/8utx) | Solution structure of a 12-mer peptide bearing a bicyclic Asx motif mimic (BAMM) as a synthetic N-cap | Descriptor: | 1,3,5-tris(bromomethyl)benzene, TRP-CYS-ASP-ALA-ALA-CYS-CYS-ALA-ALA-ALA-LYS-ALA-NH2 peptide | Authors: | Mi, T.X, Burgess, K. | Deposit date: | 2023-10-31 | Release date: | 2024-06-05 | Method: | SOLUTION NMR | Cite: | Bioinformatics leading to conveniently accessible, helix enforcing, bicyclic ASX motif mimics (BAMMs). Nat Commun, 15, 2024
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8UTW
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![BU of 8utw by Molmil](/molmil-images/mine/8utw) | KIF1A[1-393] P305L mutant APO in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTV
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![BU of 8utv by Molmil](/molmil-images/mine/8utv) | KIF1A[1-393] P305L mutant ADP bound in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTU
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![BU of 8utu by Molmil](/molmil-images/mine/8utu) | KIF1A[1-393] P305L mutant AMP-PNP bound one and two heads bound states merged, in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTT
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![BU of 8utt by Molmil](/molmil-images/mine/8utt) | KIF1A[1-393] P305L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTS
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![BU of 8uts by Molmil](/molmil-images/mine/8uts) | KIF1A[1-393] APO in complex with a microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTR
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![BU of 8utr by Molmil](/molmil-images/mine/8utr) | KIF1A[1-393] ADP bound in complex with a microtubule | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTQ
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![BU of 8utq by Molmil](/molmil-images/mine/8utq) | KIF1A[1-393] AMP-PNP bound one-head-bound state in complex with a microtubule - class T1L02* | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTP
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![BU of 8utp by Molmil](/molmil-images/mine/8utp) | KIF1A[1-393] - AMP-PNP two-heads-bound state in complex with a microtubule - class T3L1 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTO
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![BU of 8uto by Molmil](/molmil-images/mine/8uto) | KIF1A[1-393] AMP-PNP bound two-heads-bound state in complex with a microtubule - class T2L1 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTN
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![BU of 8utn by Molmil](/molmil-images/mine/8utn) | KIF1A[1-393] AMP-PNP bound two-heads-bound state in complex with a microtubule (class T23L1) | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | Authors: | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | Deposit date: | 2023-10-31 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTL
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![BU of 8utl by Molmil](/molmil-images/mine/8utl) | |
8UTK
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![BU of 8utk by Molmil](/molmil-images/mine/8utk) | IL-23R minibinder - 23R-B04dslf02IB | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 23R-B04dslf02IB, ... | Authors: | Bera, A.K, Berger, S.A, Kang, A, Baker, D. | Deposit date: | 2023-10-31 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Preclinical proof of principle for orally delivered Th17 antagonist miniproteins. Cell, 2024
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