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PDB: 3 results

The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
Descriptor:	ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Cystic fibrosis transmembrane conductance regulator, ...
Authors:	Fiedorczuk, K, Chen, J.
Deposit date:	2021-11-18
Release date:	2022-01-12
Last modified:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Mechanism of CFTR correction by type I folding correctors. Cell, 185, 2022

The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) and Lumacaftor (VX-809)
Descriptor:	Cystic fibrosis transmembrane conductance regulator, Lumacaftor
Authors:	Fiedorczuk, K, Chen, J.
Deposit date:	2021-11-19
Release date:	2022-01-12
Last modified:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.9 Å)
Cite:	Mechanism of CFTR correction by type I folding correctors. Cell, 185, 2022

The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661)
Descriptor:	ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Cystic fibrosis transmembrane conductance regulator, ...
Authors:	Fiedorczuk, K, Chen, J.
Deposit date:	2021-11-18
Release date:	2022-01-12
Last modified:	2025-05-21
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Mechanism of CFTR correction by type I folding correctors. Cell, 185, 2022