4FA8
 
 | | Multi-pronged modulation of cytokine signaling | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Secreted protein BARF1, ... | | Authors: | He, X, Shim, A.H. | | Deposit date: | 2012-05-21 | | Release date: | 2012-08-29 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FFP
 | | PylC in complex with L-lysine-Ne-D-ornithine (cocrystallized with L-lysine and D-ornithine) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, N~6~-D-ornithyl-L-lysine, ... | | Authors: | Quitterer, F, List, A, Beck, P, Bacher, A, Groll, M. | | Deposit date: | 2012-06-01 | | Release date: | 2012-09-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
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4GZ8
 | | Mouse Semaphorin 3A, domains Sema-PSI-IG | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | Deposit date: | 2012-09-06 | | Release date: | 2012-10-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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4GZ9
 | | Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2) | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | Deposit date: | 2012-09-06 | | Release date: | 2012-10-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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4FFN
 | | PylC in complex with D-ornithine and AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-ORNITHINE, MAGNESIUM ION, ... | | Authors: | Quitterer, F, List, A, Beck, P, Bacher, A, Groll, M. | | Deposit date: | 2012-06-01 | | Release date: | 2012-09-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
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4EKW
 | | Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A) | | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | | Authors: | Payandeh, J, Gamal El-Din, T.M, Scheuer, T, Zheng, N, Catterall, W.A. | | Deposit date: | 2012-04-10 | | Release date: | 2012-05-16 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.21 Å) | | Cite: | Crystal structure of a voltage-gated sodium channel in two potentially inactivated states.
Nature, 486, 2012
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4GRA
 | | Crystal structure of SULT1A1 bound with PAP | | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 1A1 | | Authors: | Kim, J, Cook, I, Wang, T, Falany, C.N, Leyh, T.S, Almo, S.C. | | Deposit date: | 2012-08-24 | | Release date: | 2013-01-16 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | The gate that governs sulfotransferase selectivity.
Biochemistry, 52, 2013
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3T9Q
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3VGN
 | | Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound 3-fluoro-4-nitrophenol | | Descriptor: | 3-fluoro-4-nitrophenol, Steroid Delta-isomerase | | Authors: | Caaveiro, J.M.M, Pybus, B, Ringe, D, Petsko, G.A, Sigala, P.A. | | Deposit date: | 2011-08-16 | | Release date: | 2012-08-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site
Proc.Natl.Acad.Sci.USA, 110, 2013
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3VN9
 | | Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state | | Descriptor: | 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine, Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION | | Authors: | Kinoshita, T, Matsuzaka, H, Nakai, R, Kirii, Y, Yokota, K, Tada, T, Matsumoto, T. | | Deposit date: | 2012-01-05 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state
J.Biochem., 151, 2012
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3UTM
 | | Crystal structure of a mouse Tankyrase-Axin complex | | Descriptor: | Axin-1, Tankyrase-1 | | Authors: | Cheng, Z, Morrone, S, Xu, W. | | Deposit date: | 2011-11-26 | | Release date: | 2012-01-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3V9F
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3W09
 | | Influenza virus neuraminidase subtype N9 (TERN) complexed with 2,3-dif guanidino-neu5ac2en inhibitor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-3-fluoro-D-glycero-D-galacto-non-2-enonic acid, ... | | Authors: | Streltsov, V.A. | | Deposit date: | 2012-10-25 | | Release date: | 2013-05-01 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
Science, 340, 2013
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4P7T
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4AK3
 | | Crystal structure of Human fibrillar procollagen type III C- propeptide trimer | | Descriptor: | CALCIUM ION, COLLAGEN ALPHA-1(III) CHAIN | | Authors: | Bourhis, J.M, Mariano, N, Zhao, Y, Harlos, K, Jones, E.Y, Moali, C, Aghajari, N, Hulmes, D.J.S. | | Deposit date: | 2012-02-21 | | Release date: | 2012-09-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural Basis of Fibrillar Collagen Trimerization and Related Genetic Disorders.
Nat.Struct.Mol.Biol., 19, 2012
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4P7V
 | | Structural insights into higher-order assembly and function of the bacterial microcompartment protein PduA | | Descriptor: | GLYCEROL, Polyhedral bodies | | Authors: | Pang, A, Frank, S, Brown, I.R, Warren, M.J, Pickersgill, R.W. | | Deposit date: | 2014-03-27 | | Release date: | 2014-06-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structural Insights into Higher Order Assembly and Function of the Bacterial Microcompartment Protein PduA.
J.Biol.Chem., 289, 2014
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4Q2A
 | | WNK1: A chloride sensor via autophosphorylation | | Descriptor: | BROMIDE ION, Serine/threonine-protein kinase WNK1 | | Authors: | Piala, A, Moon, T, Akella, R, He, H, Cobb, M.H, Goldsmith, E. | | Deposit date: | 2014-04-07 | | Release date: | 2014-05-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation.
Sci.Signal., 7, 2014
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4I1Q
 | | Crystal Structure of hBRAP1 N-BAR domain | | Descriptor: | Bridging integrator 2 | | Authors: | Sanchez-Barrena, M.J. | | Deposit date: | 2012-11-21 | | Release date: | 2013-02-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis
Plos One, 7, 2012
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4EFX
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4EUX
 | | Structure of neuronal nitric oxide synthase heme domain in complex with 6-(5-(((3R,4R)-4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)oxy)pentyl)-4-methylpyridin-2-amine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-[5-({(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}oxy)pentyl]-4-methylpyridin-2-amine, ACETATE ION, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2012-04-25 | | Release date: | 2012-07-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J.Am.Chem.Soc., 134, 2012
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4EWA
 | | Study on structure and function relationships in human Pirin with Fe ion | | Descriptor: | FE (III) ION, Pirin | | Authors: | Liu, F, Rehmani, I, Chen, L, Fu, R, Serrano, V, Wilson, D.W, Liu, A. | | Deposit date: | 2012-04-26 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4F1P
 | | Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1 | | Descriptor: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, SULFATE ION, ... | | Authors: | Sun, F, Pang, X, Zhang, K, Ma, J, Zhou, Q. | | Deposit date: | 2012-05-07 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanistic insights into regulated cargo binding by ACAP1 protein
J.Biol.Chem., 287, 2012
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4FGU
 | | Crystal structure of prolegumain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain | | Authors: | Dall, E, Brandstetter, H. | | Deposit date: | 2012-06-05 | | Release date: | 2013-07-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4J2Q
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4FWJ
 | | Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, PHOSPHATE ION, ... | | Authors: | Zhang, Q, Chen, Z. | | Deposit date: | 2012-07-01 | | Release date: | 2013-01-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
Cell Res., 23, 2013
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