Human PPAR gamma ligand binding domain in complex with JKPL53

Summary for 3VJI

DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-2-{4-butoxy-3-[({4-[(3S,5S,7S)-tricyclo[,7~]dec-1-yl]benzoyl}amino)methyl]benzyl}butanoic acid (2 entities in total)
Functional Keywordstranscription factor, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight65579
Tomioka, D.,Kuwabara, N.,Hashimoto, H.,Sato, M.,Shimizu, T. (deposition date: 2011-10-20, release date: 2012-08-29)
Primary citation
Kuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H.
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J.Med.Chem., 55:893-902, 2012
PubMed: 22185225 (PDB entries with the same primary citation)
DOI: 10.1021/jm2014293
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26480.6%7.1%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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