1L0I
 
 | | Crystal structure of butyryl-ACP I62M mutant | | Descriptor: | Acyl carrier protein, CACODYLATE ION, SODIUM ION, ... | | Authors: | Roujeinikova, A, Baldock, C, Simon, W.J, Gilroy, J, Baker, P.J, Stuitje, A.R, Rice, D.W, Slabas, A.R, Rafferty, J.B. | | Deposit date: | 2002-02-11 | | Release date: | 2003-02-11 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | X-ray Crystallographic Studies on Butyryl-ACP Reveal Flexibility of the Structure around a Putative Acyl Chain Binding Site
Structure, 10, 2002
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1HFP
 | | COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | | Descriptor: | DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Blakley, R.L, Gangjee, A. | | Deposit date: | 1997-11-04 | | Release date: | 1998-01-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
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6HXK
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3PUM
 | | Crystal structure of P domain dimer of Norovirus VA207 | | Descriptor: | Capsid | | Authors: | Chen, Y, Tan, M, Xia, M, Hao, N, Zhang, X.C, Huang, P, Jiang, X, Li, X, Rao, Z. | | Deposit date: | 2010-12-06 | | Release date: | 2011-08-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.252 Å) | | Cite: | Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
Plos Pathog., 7, 2011
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4B3Z
 | | Structure of the human collapsin response mediator protein-1, a lung cancer suppressor | | Descriptor: | DIHYDROPYRIMIDINASE-RELATED PROTEIN 1 | | Authors: | Liu, S.H, Lin, Y.H, Huang, S.F, Niou, Y.K, Huang, L.L, Chen, Y.J. | | Deposit date: | 2012-07-27 | | Release date: | 2013-08-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Structure of Human Collapsin Response Mediator Protein 1: A Possible Role of its C-Terminal Tail.
Acta Crystallogr.,Sect.F, 71, 2015
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3C86
 | | OpdA from agrobacterium radiobacter with bound product diethyl thiophosphate from crystal soaking with tetraethyl dithiopyrophosphate- 1.8 A | | Descriptor: | 1,2-ETHANEDIOL, COBALT (II) ION, FE (II) ION, ... | | Authors: | Ollis, D.L, Jackson, C.J, Foo, J.L, Kim, H.K, Carr, P.D, Liu, J.W, Salem, G. | | Deposit date: | 2008-02-10 | | Release date: | 2008-02-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
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1HFR
 | | COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | | Descriptor: | DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Blakley, R.L, Gangjee, A. | | Deposit date: | 1997-11-04 | | Release date: | 1998-01-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
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6U2X
 | | Structure of ALDH7A1 mutant E399G complexed with NAD | | Descriptor: | Alpha-aminoadipic semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Tanner, J.J, Korasick, D.A, Laciak, A.R. | | Deposit date: | 2019-08-20 | | Release date: | 2019-11-06 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
J. Inherit. Metab. Dis., 43, 2020
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5JY6
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3AMH
 | | crystal structure of cellulase 12A from Thermotoga maritima | | Descriptor: | Endo-1,4-beta-glucanase | | Authors: | Cheng, Y.-S, Ko, T.-P, Liu, J.-R, Guo, R.-T. | | Deposit date: | 2010-08-20 | | Release date: | 2011-03-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Crystal structure and substrate-binding mode of cellulase 12A from Thermotoga maritima
Proteins, 79, 2011
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6RME
 | | Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N | | Descriptor: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | | Authors: | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | | Deposit date: | 2019-05-06 | | Release date: | 2020-07-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Nat Commun, 11, 2020
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5KUH
 | | GluK2EM with LY466195 | | Descriptor: | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 2 | | Authors: | Meyerson, J.R, Chittori, S, Merk, A, Rao, P, Han, T.H, Serpe, M, Mayer, M.L, Subramaniam, S. | | Deposit date: | 2016-07-13 | | Release date: | 2016-09-07 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (11.6 Å) | | Cite: | Structural basis of kainate subtype glutamate receptor desensitization.
Nature, 537, 2016
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2KXM
 | | Solution NMR Structure of the 27 nucleotide engineered neomycin sensing riboswitch RNA-ribostmycin complex | | Descriptor: | RIBOSTAMYCIN, RNA (27-MER) | | Authors: | Duchardt-Ferner, E, Weigand, J.E, Ohlenschlager, O, Schmidtke, S.R, Suess, B, Wohnert, J. | | Deposit date: | 2010-05-10 | | Release date: | 2011-04-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch.
Angew.Chem.Int.Ed.Engl., 49, 2010
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2XWS
 | | ANAEROBIC COBALT CHELATASE (CbiX) FROM ARCHAEOGLOBUS FULGIDUS | | Descriptor: | SIROHYDROCHLORIN COBALTOCHELATASE | | Authors: | Romao, C.V, Ladakis, D, Lobo, S.A.L, Carrondo, M.A, Brindley, A.A, Deery, E, Matias, P.M, Pickersgill, R.W, Saraiva, L.M, Warren, M.J. | | Deposit date: | 2010-11-04 | | Release date: | 2010-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1OHJ
 | | HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM | | Descriptor: | DIHYDROFOLATE REDUCTASE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W. | | Deposit date: | 1997-09-17 | | Release date: | 1998-04-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Biochemistry, 36, 1997
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2VGX
 | | Structure of the Yersinia enterocolitica Type III Secretion Translocator Chaperone SycD | | Descriptor: | CHAPERONE SYCD | | Authors: | Buttner, C.R, Sorg, I, Cornelis, G.R, Heinz, D.W, Niemann, H.H. | | Deposit date: | 2007-11-16 | | Release date: | 2007-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the Yersinia Enterocolitica Type III Secretion Chaperone Sycd
J.Mol.Biol., 375, 2008
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3U3W
 | | Crystal Structure of Bacillus thuringiensis PlcR in complex with the peptide PapR7 and DNA | | Descriptor: | 5'-D(P*AP*TP*AP*TP*GP*AP*AP*AP*TP*AP*TP*TP*GP*CP*AP*TP*AP*G)-3', 5'-D(P*CP*TP*AP*TP*GP*CP*AP*AP*TP*AP*TP*TP*TP*CP*AP*TP*AP*T)-3', C-terminus heptapeptide from PapR protein, ... | | Authors: | Grenha, R, Slamti, L, Bouillaut, L, Lereclus, D, Nessler, S. | | Deposit date: | 2011-10-06 | | Release date: | 2013-01-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR.
Proc.Natl.Acad.Sci.USA, 110, 2013
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6HRS
 | | Structure of the TRPML2 ELD at pH 4.5 | | Descriptor: | GLYCEROL, Mucolipin-2 | | Authors: | Bader, N, Viet, K.K, Wagner, A, Hellmich, U.A, Schindelin, H. | | Deposit date: | 2018-09-28 | | Release date: | 2019-06-19 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.
Structure, 27, 2019
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3TWM
 | | Crystal structure of Arabidopsis thaliana FPG | | Descriptor: | 5'-D(*AP*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*AP*GP*AP*CP*GP*TP*GP*GP*AP*CP*GP*C)-3', Formamidopyrimidine-DNA glycosylase 1 | | Authors: | Duclos, S, Aller, P, Wallace, S.S, Doublie, S. | | Deposit date: | 2011-09-22 | | Release date: | 2012-07-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
Dna Repair, 11, 2012
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2XWQ
 | | Anaerobic cobalt chelatase from Archeaoglobus fulgidus (CbiX) in complex with metalated sirohydrochlorin product | | Descriptor: | COBALT SIROHYDROCHLORIN, SIROHYDROCHLORIN COBALTOCHELATASE | | Authors: | Ladakis, D, Brindley, A.A, Deery, E, Warren, M.J, Pickersgill, R.W. | | Deposit date: | 2010-11-04 | | Release date: | 2010-12-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Evolution in a Family of Chelatases Facilitated by the Introduction of Active Site Asymmetry and Protein Oligomerization.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1YND
 | | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A resolution | | Descriptor: | Peptidyl-prolyl cis-trans isomerase A, SANGLIFEHRIN A | | Authors: | Kallen, J, Sedrani, R, Zenke, G, Wagner, J. | | Deposit date: | 2005-01-24 | | Release date: | 2005-04-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution.
J.Biol.Chem., 280, 2005
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3N1B
 | | C-terminal domain of Vps54 subunit of the GARP complex | | Descriptor: | Vacuolar protein sorting-associated protein 54 | | Authors: | Perez-Victoria, F.J, Abascal-Palacios, G, Tascon, I, Kajava, A, Pioro, E.P, Bonifacino, J.S, Hierro, A. | | Deposit date: | 2010-05-15 | | Release date: | 2010-07-14 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3N1E
 | | Vps54 C-terminal domain | | Descriptor: | GLYCEROL, MAGNESIUM ION, Vacuolar protein sorting-associated protein 54 | | Authors: | Perez-Victoria, F.J, Abascal-Palacios, G, Tascon, I, Kajava, A, Pioro, E.P, Bonifacino, J.S, Hierro, A. | | Deposit date: | 2010-05-15 | | Release date: | 2010-07-14 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.702 Å) | | Cite: | Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
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7E1L
 | | Crystal structure of apo form PhlH | | Descriptor: | DUF1956 domain-containing protein | | Authors: | Zhang, N, Wu, J, He, Y.X, Ge, H. | | Deposit date: | 2021-02-01 | | Release date: | 2022-02-02 | | Last modified: | 2022-08-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules.
J.Biol.Chem., 298, 2022
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7E1N
 | | Crystal structure of PhlH in complex with 2,4-diacetylphloroglucinol | | Descriptor: | 2,4-bis[(1R)-1-oxidanylethyl]benzene-1,3,5-triol, DUF1956 domain-containing protein | | Authors: | Zhang, N, Wu, J, He, Y.X, Ge, H. | | Deposit date: | 2021-02-02 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules.
J.Biol.Chem., 298, 2022
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