8G4O
| Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA | Descriptor: | (5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Sun, C, Gouaux, E. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622, 2023
|
|
8FE1
| Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State | Descriptor: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gibbs, E, Chakrapani, S. | Deposit date: | 2022-12-05 | Release date: | 2023-03-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nat Commun, 14, 2023
|
|
7QL5
| Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-19 | Release date: | 2022-02-09 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
7QKO
| Torpedo muscle-type nicotinic acetylcholine receptor - Resting conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-18 | Release date: | 2022-02-09 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
7QL6
| Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | Descriptor: | 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | Deposit date: | 2021-12-19 | Release date: | 2022-02-09 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
8C1W
| |
8C21
| |
8C20
| |
8C1Z
| |
8DN2
| |
8DN4
| Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-1, Glycine receptor subunit beta,Green fluorescent protein,Glycine receptor beta, ... | Authors: | Liu, X, Wang, W. | Deposit date: | 2022-07-10 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Asymmetric gating of a human hetero-pentameric glycine receptor. Nat Commun, 14, 2023
|
|
8DN5
| |
8DN3
| |
8EIS
| Cryo-EM structure of octopus sensory receptor CRT1 | Descriptor: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Octopus sensory receptor | Authors: | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, Bellono, N.W, Hibbs, R.E. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Sensory specializations drive octopus and squid behaviour. Nature, 616, 2023
|
|
8F6Y
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-17 | Release date: | 2023-06-07 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
8ESK
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-10-14 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
8F6Z
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-17 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
8F2S
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | Deposit date: | 2022-11-08 | Release date: | 2023-06-07 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
|
|
8DD2
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Zhu, S, Hibbs, R.E. | Deposit date: | 2022-06-17 | Release date: | 2022-08-17 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and dynamic mechanisms of GABA A receptor modulators with opposing activities. Nat Commun, 13, 2022
|
|
8DD3
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Zhu, S, Hibbs, R.E. | Deposit date: | 2022-06-17 | Release date: | 2022-08-17 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and dynamic mechanisms of GABA A receptor modulators with opposing activities. Nat Commun, 13, 2022
|
|
8AW2
| Mouse serotonin 5-HT3A receptor in complex with vortioxetine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2022-08-29 | Release date: | 2024-03-06 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 31, 2024
|
|
8AXD
| Human serotonin 5-HT3A receptor (apo, resting conformation) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2022-08-31 | Release date: | 2024-03-06 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 31, 2024
|
|
8BEJ
| GABA-A receptor a5 homomer - a5V3 - APO | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5 | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | Deposit date: | 2022-10-21 | Release date: | 2023-11-01 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
8BHM
| GABA-A receptor a5 homomer - a5V3 - DMCM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y. | Deposit date: | 2022-10-31 | Release date: | 2023-11-01 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|
8BHB
| GABA-A receptor a5 homomer - a5V3 - RO154513 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | Authors: | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Chirgadze, D.Y, Wahid, A.A. | Deposit date: | 2022-10-30 | Release date: | 2023-11-01 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors. Nat.Struct.Mol.Biol., 30, 2023
|
|