PDB: 41522 resultsInfo pagesStatus searchChemie searchBIRD

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7O5G	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-164 Descriptor: 14-3-3 protein sigma, 4-(4-methanoylphenyl)carbonyl-~{N},~{N}-dimethyl-piperazine-1-carboxamide, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-08 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
4XQE	Crystal Structure of the Homospermidine Synthase (HSS) variant H296S from Blastochloris viridis in Complex with NAD and Agmatine Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ACETATE ION, AGMATINE, ... Authors: Krossa, S. Deposit date: 2015-01-19 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism. Sci Rep, 6, 2016
7O6M	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-097 Descriptor: (5-methanoyl-2-nitro-phenyl) 1-methylpyrazole-4-sulfonate, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-11 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXS	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-184 Descriptor: 14-3-3 protein sigma, 4-[(6-fluoranyl-2,3-dihydro-1,4-benzoxazin-4-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-19 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
3O2Q	Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex Descriptor: PHOSPHATE ION, RNA polymerase II CTD Serine-5 phosphopeptide, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, ... Authors: Tong, L, Xiang, K. Deposit date: 2010-07-22 Release date: 2010-10-06 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature, 467, 2010
7NZV	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-120 Descriptor: 14-3-3 protein sigma, 4-methanoyl-N-methyl-N-(oxan-4-yl)benzenesulfonamide, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-24 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O3R	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-042 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-02 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O5C	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-159 Descriptor: 14-3-3 protein sigma, 4-methanoyl-~{N}-(1-methylpyrazol-3-yl)benzamide, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-08 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NWS	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-185 Descriptor: 14-3-3 protein sigma, 4-[(7-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-17 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-182 Descriptor: 14-3-3 protein sigma, 4-[(6-chloranyl-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-19 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O34	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-043 Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Transcription factor p65, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-01 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
4QIL	Crystal structure of the ROQ domain of human Roquin in complex with the Hmg19 stem-loop RNA Descriptor: 5'-R(*CP*UP*CP*CP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*GP*GP*GP*A)-3', CALCIUM ION, Roquin-1 Authors: Tan, D, Tong, L. Deposit date: 2014-05-31 Release date: 2014-07-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nat.Struct.Mol.Biol., 21, 2014
7NR7	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-111 Descriptor: 14-3-3 protein sigma, 4-(2-chloranyl-5-methoxy-benzimidazol-1-yl)benzaldehyde, 4-(2-chloranyl-6-methoxy-benzimidazol-1-yl)benzaldehyde, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-03 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O5O	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-165 Descriptor: 14-3-3 protein sigma, 4-methanoyl-~{N}-[(1-methylpyrazol-4-yl)methyl]benzamide, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-09 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O59	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-192 Descriptor: 14-3-3 protein sigma, 4-(5-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde, 4-(6-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-08 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O5X	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-173 Descriptor: 14-3-3 protein sigma, 4-(4-methoxypiperidin-1-yl)carbonylbenzaldehyde, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-09 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
4XTT	Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+ (RCK) C domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP) Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Putative potassium transport protein Authors: Kim, H, Youn, S.J, Kim, S.O, Ko, J, Lee, J.O, Choi, B.S. Deposit date: 2015-01-24 Release date: 2015-05-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.708 Å) Cite: Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+ (RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP) J.Biol.Chem., 290, 2015
7O5F	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-161 Descriptor: 14-3-3 protein sigma, 4-morpholin-4-ylcarbonylbenzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-08 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O6I	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-085 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-11 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O5P	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-166 Descriptor: 14-3-3 protein sigma, 4-methanoyl-~{N}-(oxan-4-ylmethyl)benzamide, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-09 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O6O	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-096 Descriptor: (5-methanoyl-2-nitro-phenyl) propane-2-sulfonate, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-11 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6P0D	Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick Descriptor: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... Authors: Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. Deposit date: 2019-05-16 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
7O6F	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-178 Descriptor: 14-3-3 protein sigma, 4-[4-(2-hydroxyethyl)piperidin-1-yl]carbonylbenzaldehyde, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-11 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2020-02-21 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
7NV4	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-188 Descriptor: 14-3-3 protein sigma, 4-(2,3-dihydroindol-1-ylsulfonyl)benzaldehyde, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-03-15 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021

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