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7O5F

14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-161

Summary for 7O5F
Entry DOI10.2210/pdb7o5f/pdb
Related6QHL
Descriptor14-3-3 protein sigma, Transcription factor p65, CHLORIDE ION, ... (7 entities in total)
Functional Keywordsbenzaldehyde, covalent fragment, p65, 1433, rela, peptide binding protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight28391.91
Authors
Wolter, M.,Ottmann, C. (deposition date: 2021-04-08, release date: 2021-06-09, Last modification date: 2024-01-31)
Primary citationWolter, M.,Valenti, D.,Cossar, P.J.,Hristeva, S.,Levy, L.M.,Genski, T.,Hoffmann, T.,Brunsveld, L.,Tzalis, D.,Ottmann, C.
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach.
J.Med.Chem., 64:8423-8436, 2021
Cited by
PubMed: 34076416
DOI: 10.1021/acs.jmedchem.1c00401
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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