3G6O
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3DBA
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![BU of 3dba by Molmil](/molmil-images/mine/3dba) | Crystal structure of the cGMP-bound GAF a domain from the photoreceptor phosphodiesterase 6C | Descriptor: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GLYCEROL, GUANOSINE-3',5'-MONOPHOSPHATE | Authors: | Martinez, S.E, Heikaus, C.C, Klevit, R.E, Beavo, J.A. | Deposit date: | 2008-05-30 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change. J.Biol.Chem., 283, 2008
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3CI6
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![BU of 3ci6 by Molmil](/molmil-images/mine/3ci6) | Crystal structure of the GAF domain from Acinetobacter phosphoenolpyruvate-protein phosphotransferase | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Cuff, M.E, Shackelford, G, Kim, Y, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-03-10 | Release date: | 2008-05-13 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of the GAF domain from Acinetobacter phosphoenolpyruvate-protein phosphotransferase. TO BE PUBLISHED
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3C2W
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3BJC
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![BU of 3bjc by Molmil](/molmil-images/mine/3bjc) | Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor | Descriptor: | 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide, MAGNESIUM ION, ZINC ION, ... | Authors: | Chen, G, Wang, H, Howard, R, Cai, J, Wan, Y, Ke, H. | Deposit date: | 2007-12-03 | Release date: | 2008-04-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM., 75, 2008
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2Y8H
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2Y79
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![BU of 2y79 by Molmil](/molmil-images/mine/2y79) | STRUCTURE OF THE FIRST GAF DOMAIN E87A MUTANT OF MYCOBACTERIUM TUBERCULOSIS DOSS | Descriptor: | CALCIUM ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Cho, H.Y, Cho, H.J, Kang, B.S. | Deposit date: | 2011-01-30 | Release date: | 2011-02-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Blockage of the Channel to Heme by the E87 Side Chain in the Gaf Domain of Mycobacterium Tuberculosis Doss Confers the Unique Sensitivity of Doss to Oxygen. FEBS Lett., 585, 2011
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2XSS
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2W3H
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![BU of 2w3h by Molmil](/molmil-images/mine/2w3h) | Cyanide bound structure of the first GAF domain of Mycobacterium tuberculosis DosS | Descriptor: | CALCIUM ION, CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Kang, B.S, Cho, H.Y, Cho, H.J. | Deposit date: | 2008-11-12 | Release date: | 2009-03-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insight Into the Heme-Based Redox Sensing by Doss from Mycobacterium Tuberculosis. J.Biol.Chem., 284, 2009
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2W3G
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2W3F
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2W3E
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2W3D
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2VZW
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![BU of 2vzw by Molmil](/molmil-images/mine/2vzw) | X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis | Descriptor: | ACETATE ION, OXYGEN MOLECULE, PROBABLE HISTIDINE KINASE RESPONSE REGULATOR, ... | Authors: | Podust, L.M, Ioanoviciu, A, Ortiz de Montellano, P.R. | Deposit date: | 2008-08-06 | Release date: | 2009-03-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | 2.3 A X-Ray Structure of the Heme-Bound Gaf Domain of Sensory Histidine Kinase Dost of Mycobacterium Tuberculosis. Biochemistry, 47, 2008
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2VKS
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2VJW
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2VEA
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2OOL
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![BU of 2ool by Molmil](/molmil-images/mine/2ool) | Crystal structure of the chromophore-binding domain of an unusual bacteriophytochrome RpBphP3 from R. palustris | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Sensor protein | Authors: | Yang, X, Stojkovic, E.A, Kuk, J, Moffat, K. | Deposit date: | 2007-01-25 | Release date: | 2007-07-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the chromophore binding domain of an unusual bacteriophytochrome, RpBphP3, reveals residues that modulate photoconversion. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2O9C
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![BU of 2o9c by Molmil](/molmil-images/mine/2o9c) | Crystal Structure of Bacteriophytochrome chromophore binding domain at 1.45 angstrom resolution | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | Authors: | Wagner, J.R, Brunzelle, J.S, Vierstra, R.D, Forest, K.T. | Deposit date: | 2006-12-13 | Release date: | 2007-03-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | High resolution structure of deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution. J.Biol.Chem., 282, 2007
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2O9B
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![BU of 2o9b by Molmil](/molmil-images/mine/2o9b) | Crystal Structure of Bacteriophytochrome chromophore binding domain | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | Authors: | Wagner, J.R, Brunzelle, J.S, Vierstra, R.D, Forest, K.T. | Deposit date: | 2006-12-13 | Release date: | 2007-03-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | High resolution structure of deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution. J.Biol.Chem., 282, 2007
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2M7V
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![BU of 2m7v by Molmil](/molmil-images/mine/2m7v) | Green Light-Absorbing State of TePixJ, an Active Cyanobacteriochrome Domain | Descriptor: | Methyl-accepting chemotaxis protein, PHYCOVIOLOBILIN | Authors: | Cornilescu, G, Cornilescu, C.C, Burgie, S.E, Walker, J.M, Markley, J.L, Ulijasz, A.T, Vierstra, R.D. | Deposit date: | 2013-05-01 | Release date: | 2014-01-01 | Last modified: | 2024-03-13 | Method: | SOLUTION NMR | Cite: | Structural and Flexibility Variations Between the Ground and Photoactivated States of a Blue/Green Light-Absorbing Cyanobacteriochrome To be Published
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2M7U
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![BU of 2m7u by Molmil](/molmil-images/mine/2m7u) | Blue Light-Absorbing State of TePixJ, an Active Cyanobacteriochrome Domain | Descriptor: | Methyl-accepting chemotaxis protein, Phycoviolobilin, blue light-absorbing form | Authors: | Cornilescu, G, Cornilescu, C.C, Burgie, S.E, Walker, J.M, Markley, J.L, Ulijasz, A.T, Vierstra, R.D. | Deposit date: | 2013-05-01 | Release date: | 2014-01-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural and Flexibility Variations Between the Ground and Photoactivated States of a Blue/Green Light-Absorbing Cyanobacteriochrome To be Published
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2LB9
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![BU of 2lb9 by Molmil](/molmil-images/mine/2lb9) | Refined solution structure of a cyanobacterial phytochrome gaf domain in the red light-absorbing ground state (corrected pyrrole ring planarity) | Descriptor: | PHYCOCYANOBILIN, Sensor histidine kinase | Authors: | Cornilescu, C.C, Cornilescu, G, Ulijasz, A.T, Vierstra, R.D, Markley, J.L. | Deposit date: | 2011-03-23 | Release date: | 2011-06-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure of a cyanobacterial phytochrome GAF domain in the red-light-absorbing ground state. J.Mol.Biol., 383, 2008
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2LB5
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![BU of 2lb5 by Molmil](/molmil-images/mine/2lb5) | Refined Structural Basis for the Photoconversion of A Phytochrome to the Activated FAR-RED LIGHT-ABSORBING Form | Descriptor: | PHYCOCYANOBILIN, Sensor histidine kinase | Authors: | Cornilescu, C.C, Cornilescu, G, Ulijasz, A.T, Vierstra, R.D, Markley, J.L. | Deposit date: | 2011-03-23 | Release date: | 2011-06-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis for the photoconversion of a phytochrome to the activated Pfr form. Nature, 463, 2010
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2KOI
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![BU of 2koi by Molmil](/molmil-images/mine/2koi) | Refined solution structure of a cyanobacterial phytochrome GAF domain in the red light-absorbing ground state | Descriptor: | PHYCOCYANOBILIN, Sensor protein | Authors: | Cornilescu, C.C, Cornilescu, G, Ulijasz, A.T, Vierstra, R.D, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2009-09-22 | Release date: | 2009-11-03 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Structural basis for the photoconversion of a phytochrome to the activated Pfr form Nature, 463, 2010
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