3DBA

Crystal structure of the cGMP-bound GAF a domain from the photoreceptor phosphodiesterase 6C

Summary for 3DBA

• Entry DOI: 10.2210/pdb3dba/pdb
• Descriptor: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', GUANOSINE-3',5'-MONOPHOSPHATE, GLYCEROL, ... (4 entities in total)
• Functional Keywords: 3', 5' cgmp, gaf domain, cyclic nucleotide phosphodiesterase, cgmp, hydrolase, lipoprotein, membrane, prenylation, sensory transduction, vision
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P52731
• Total number of polymer chains: 2
• Total formula weight: 42602.76

Authors

Martinez, S.E.,Heikaus, C.C.,Klevit, R.E.,Beavo, J.A. (deposition date: 2008-05-30, release date: 2008-07-01, Last modification date: 2024-02-21)

• Primary citation: Martinez, S.E.,Heikaus, C.C.,Klevit, R.E.,Beavo, J.A.; The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change.; J.Biol.Chem., 283:25913-25919, 2008; PubMed: 18614542; DOI: 10.1074/jbc.M802891200

Experimental method

X-RAY DIFFRACTION (2.57 Å)