5O86
 
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6D0Z
 | | Polymerase Eta cytarabine (AraC) extension ternary complex | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ... | | Authors: | Rechkoblit, O, Aggarwal, A.K. | | Deposit date: | 2018-04-11 | | Release date: | 2018-09-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
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3HK2
 | | Crystal structure of T. thermophilus Argonaute N478 mutant protein complexed with DNA guide strand and 19-nt RNA target strand | | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | | Deposit date: | 2009-05-22 | | Release date: | 2009-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
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3PXP
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2HKB
 | | NMR Structure of the B-DNA Dodecamer CTCGGCGCCATC | | Descriptor: | 5'-D(*CP*TP*CP*GP*GP*CP*GP*CP*CP*AP*TP*C)-3', 5'-D(*GP*AP*TP*GP*GP*CP*GP*CP*CP*GP*AP*G)-3' | | Authors: | Wang, F, DeMuro, N.E, Elmquist, C.E, Stover, J.S, Rizzo, C.J, Stone, M.P. | | Deposit date: | 2006-07-03 | | Release date: | 2006-10-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.
J.Am.Chem.Soc., 128, 2006
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2ES2
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1R49
 | | Human topoisomerase I (Topo70) double mutant K532R/Y723F | | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | | Authors: | Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.13 Å) | | Cite: | The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem., 279, 2004
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2LXV
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352D
 | | THE CRYSTAL STRUCTURE OF A PARALLEL-STRANDED PARALLEL-STRANDED GUANINE TETRAPLEX AT 0.95 ANGSTROM RESOLUTION | | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*GP*GP*GP*GP*T)-3'), SODIUM ION | | Authors: | Phillips, K, Dauter, Z, Murchie, A.I.H, Lilley, D.M.J, Luisi, B. | | Deposit date: | 1997-09-04 | | Release date: | 1997-11-10 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (0.95 Å) | | Cite: | The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution.
J.Mol.Biol., 273, 1997
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1RRJ
 | | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | | Authors: | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | | Deposit date: | 2003-12-08 | | Release date: | 2004-07-06 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
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2OBH
 | | Centrin-XPC peptide | | Descriptor: | CALCIUM ION, Centrin-2, DNA-repair protein complementing XP-C cells | | Authors: | Charbonnier, J.B. | | Deposit date: | 2006-12-19 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.
J.Mol.Biol., 373, 2007
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6HKA
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6G1T
 | | TraN, a repressor of an Enterococcus conjugative type IV secretion system | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AM32, DNA (34-MER) | | Authors: | Goessweiner-Mohr, N, Kohler, V, Keller, W. | | Deposit date: | 2018-03-22 | | Release date: | 2018-07-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | TraN: A novel repressor of an Enterococcus conjugative type IV secretion system.
Nucleic Acids Res., 46, 2018
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5A20
 | | Structure of bacteriophage SPP1 head-to-tail interface filled with DNA and tape measure protein | | Descriptor: | 15 PROTEIN, HEAD COMPLETION PROTEIN GP16, MAJOR TAIL PROTEIN GP17.1, ... | | Authors: | Chaban, Y, Lurz, R, Brasiles, S, Cornilleau, C, Karreman, M, Zinn-Justin, S, Tavares, P, Orlova, E.V. | | Deposit date: | 2015-05-06 | | Release date: | 2015-06-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Structural Rearrangements in the Phage Head-to-Tail Interface During Assembly and Infection.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5A21
 | | Structure of bacteriophage SPP1 head-to-tail interface without DNA and tape measure protein | | Descriptor: | 15 PROTEIN, HEAD COMPLETION PROTEIN GP16, MAJOR TAIL PROTEIN 17.1, ... | | Authors: | Chaban, Y, Lurz, R, Brasiles, S, Cornilleau, C, Karreman, M, Zinn-Justin, S, Tavares, P, Orlova, E.V. | | Deposit date: | 2015-05-06 | | Release date: | 2015-06-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7.2 Å) | | Cite: | Structural Rearrangements in the Phage Head-to-Tail Interface During Assembly and Infection.
Proc.Natl.Acad.Sci.USA, 112, 2015
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8ER8
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4C5X
 | | Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethyl-cytosine Modification | | Descriptor: | 5'-D(CP*GP*CP*GP*AP*AP*TP*TP*5HCP*GP*CP*GP)-3', MAGNESIUM ION | | Authors: | McDonough, M, El-Sagheer, A.H, Brown, T, Schofield, C.J. | | Deposit date: | 2013-09-16 | | Release date: | 2013-10-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural insights into how 5-hydroxymethylation influences transcription factor binding.
Chem. Commun. (Camb.), 50, 2014
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1P24
 | | Crystal structure of cobalt(II)-d(GGCGCC)2 | | Descriptor: | COBALT (II) ION, DNA (5'-D(*GP*GP*CP*GP*CP*C)-3') | | Authors: | Labiuk, S.L, Delbaere, L.T, Lee, J.S. | | Deposit date: | 2003-04-14 | | Release date: | 2003-12-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Cobalt(II), nickel(II) and zinc(II) do not bind to intra-helical N(7)
guanine positions in the B-form crystal structure of d(GGCGCC)
J.Biol.Inorg.Chem., 8, 2003
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6MUP
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6MUO
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1S3O
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6K1I
 | | Human nucleosome core particle with gammaH2A.X variant | | Descriptor: | CHLORIDE ION, DNA (147-MER), Histone H2AX, ... | | Authors: | Sharma, D, De Falco, L, Davey, C.A. | | Deposit date: | 2019-05-10 | | Release date: | 2020-01-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
Nat Commun, 10, 2019
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403D
 | | 5'-D(*CP*GP*CP*(HYD)AP*AP*AP*TP*TP*TP*GP*CP*G)-3', 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE | | Descriptor: | 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*(IGU)P*AP*AP*TP*TP*TP*GP*CP*G)-3'), MAGNESIUM ION | | Authors: | Robinson, H, Gao, Y.-G, Bauer, C, Roberts, C, Switzer, C, Wang, A.H.-J. | | Deposit date: | 1998-06-10 | | Release date: | 1998-07-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | 2'-Deoxyisoguanosine adopts more than one tautomer to form base pairs with thymidine observed by high-resolution crystal structure analysis.
Biochemistry, 37, 1998
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6K1K
 | | Human nucleosome core particle with H2A.X S139E variant | | Descriptor: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | | Authors: | Sharma, D, De Falco, L, Davey, C.A. | | Deposit date: | 2019-05-10 | | Release date: | 2020-01-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
Nat Commun, 10, 2019
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6K1J
 | | Human nucleosome core particle with H2A.X variant | | Descriptor: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | | Authors: | Sharma, D, De Falco, L, Davey, C.A. | | Deposit date: | 2019-05-10 | | Release date: | 2020-01-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
Nat Commun, 10, 2019
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