5V5S
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![BU of 5v5s by Molmil](/molmil-images/mine/5v5s) | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | Descriptor: | Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC | Authors: | wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-15 | Release date: | 2017-04-19 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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7M4P
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![BU of 7m4p by Molmil](/molmil-images/mine/7m4p) | Multidrug Efflux pump AdeJ with Eravacycline bound | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Efflux pump membrane transporter, Eravacycline | Authors: | Zhang, Z. | Deposit date: | 2021-03-22 | Release date: | 2021-05-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. Mbio, 12, 2021
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7M4Q
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![BU of 7m4q by Molmil](/molmil-images/mine/7m4q) | Multidrug Efflux pump AdeJ | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2021-03-22 | Release date: | 2021-05-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. Mbio, 12, 2021
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7RR8
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![BU of 7rr8 by Molmil](/molmil-images/mine/7rr8) | Multidrug efflux pump subunit AcrB | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | Deposit date: | 2021-08-09 | Release date: | 2022-08-17 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Multidrug efflux pump subunit AcrB To Be Published
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7RR7
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![BU of 7rr7 by Molmil](/molmil-images/mine/7rr7) | Multidrug efflux pump subunit AcrB | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | Deposit date: | 2021-08-09 | Release date: | 2022-08-17 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Multidrug efflux pump subunit AcrB To Be Published
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7RR6
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![BU of 7rr6 by Molmil](/molmil-images/mine/7rr6) | Multidrug efflux pump subunit AcrB | Descriptor: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | Authors: | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | Deposit date: | 2021-08-09 | Release date: | 2022-08-17 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Multidrug efflux pump subunit AcrB To Be Published
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1LNW
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![BU of 1lnw by Molmil](/molmil-images/mine/1lnw) | |
5KHN
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![BU of 5khn by Molmil](/molmil-images/mine/5khn) | |
4U8Y
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![BU of 4u8y by Molmil](/molmil-images/mine/4u8y) | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Pos, K.M. | Deposit date: | 2014-08-05 | Release date: | 2014-10-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife, 3, 2014
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4U8V
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![BU of 4u8v by Molmil](/molmil-images/mine/4u8v) | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Pos, K.M. | Deposit date: | 2014-08-04 | Release date: | 2014-10-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife, 3, 2014
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4U95
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![BU of 4u95 by Molmil](/molmil-images/mine/4u95) | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Pos, K.M. | Deposit date: | 2014-08-05 | Release date: | 2014-10-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB eLife, 3, 2014
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4U96
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![BU of 4u96 by Molmil](/molmil-images/mine/4u96) | |
5UJ9
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![BU of 5uj9 by Molmil](/molmil-images/mine/5uj9) | |
5UJA
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![BU of 5uja by Molmil](/molmil-images/mine/5uja) | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4 | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1 | Authors: | Johnson, Z.L, Chen, J. | Deposit date: | 2017-01-17 | Release date: | 2017-02-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1. Cell, 168, 2017
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7SZT
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![BU of 7szt by Molmil](/molmil-images/mine/7szt) | Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in low pH (protonated state) | Descriptor: | Dodecyldimethylphosphine oxide, L10 monobody, Multidrug resistance protein, ... | Authors: | Kermani, A.A, Stockbridge, R.B, Burata, O.E. | Deposit date: | 2021-11-29 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
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2I68
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![BU of 2i68 by Molmil](/molmil-images/mine/2i68) | Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE | Descriptor: | Protein emrE | Authors: | Fleishman, S.J, Harrington, S.E, Enosh, A, Halperin, D, Tate, C.G, Ben-Tal, N. | Deposit date: | 2006-08-28 | Release date: | 2006-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (7.5 Å) | Cite: | Quasi-symmetry in the Cryo-EM Structure of EmrE Provides the Key to Modeling its Transmembrane Domain J.Mol.Biol., 364, 2006
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7WLS
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![BU of 7wls by Molmil](/molmil-images/mine/7wls) | Crystal structure of the multidrug efflux transporter BpeB from Burkholderia pseudomallei | Descriptor: | Efflux pump membrane transporter, TETRAETHYLENE GLYCOL, UNDECYL-MALTOSIDE | Authors: | Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. | Deposit date: | 2022-01-13 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
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7WLV
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![BU of 7wlv by Molmil](/molmil-images/mine/7wlv) | Crystal Structure of the Multidrug effulx transporter BpeF from Burkholderia pseudomallei. | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter | Authors: | Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. | Deposit date: | 2022-01-13 | Release date: | 2023-07-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
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8T1P
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![BU of 8t1p by Molmil](/molmil-images/mine/8t1p) | |
8SZC
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![BU of 8szc by Molmil](/molmil-images/mine/8szc) | |
8T3K
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![BU of 8t3k by Molmil](/molmil-images/mine/8t3k) | |
2J8S
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![BU of 2j8s by Molmil](/molmil-images/mine/2j8s) | Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors | Descriptor: | ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-ALPHA-D-MALTOSIDE, ... | Authors: | Sennhauser, G, Amstutz, P, Briand, C, Storchenegger, O, Gruetter, M.G. | Deposit date: | 2006-10-27 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Drug Export Pathway of Multidrug Exporter Acrb Revealed by Darpin Inhibitors. Plos Biol., 5, 2007
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8FMV
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![BU of 8fmv by Molmil](/molmil-images/mine/8fmv) | |
8FHK
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![BU of 8fhk by Molmil](/molmil-images/mine/8fhk) | |
2V50
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![BU of 2v50 by Molmil](/molmil-images/mine/2v50) | |