6FMO
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2CCB
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![BU of 2ccb by Molmil](/molmil-images/mine/2ccb) | Complexes of Dodecin with Flavin and Flavin-like Ligands | Descriptor: | CHLORIDE ION, MAGNESIUM ION, RIBOFLAVIN, ... | Authors: | Grininger, M, Zeth, K, Oesterhelt, D. | Deposit date: | 2006-01-13 | Release date: | 2006-01-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Dodecins: A Family of Lumichrome Binding Proteins. J.Mol.Biol., 357, 2006
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1QKB
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![BU of 1qkb by Molmil](/molmil-images/mine/1qkb) | OLIGO-PEPTIDE BINDING PROTEIN (OPPA) COMPLEXED WITH KVK | Descriptor: | ACETATE ION, PEPTIDE LYS-VAL-LYS, PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, ... | Authors: | Tame, J.R.H, Sleigh, S.H, Wilkinson, A.J. | Deposit date: | 1999-07-14 | Release date: | 1999-09-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic and Calorimetric Analysis of Peptide Binding to Oppa Protein J.Mol.Biol., 291, 1999
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2GY5
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![BU of 2gy5 by Molmil](/molmil-images/mine/2gy5) | Tie2 Ligand-Binding Domain Crystal Structure | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | Authors: | Barton, W.A, Nikolov, D.B. | Deposit date: | 2006-05-09 | Release date: | 2006-06-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Nat.Struct.Mol.Biol., 13, 2006
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8G4S
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![BU of 8g4s by Molmil](/molmil-images/mine/8g4s) | 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs. | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S25, ... | Authors: | Eiler, D.R, Wimberly, B.T, Bilodeau, D.Y, Rissland, O.S, Kieft, J.S. | Deposit date: | 2023-02-10 | Release date: | 2024-01-31 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure, 32, 2024
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6X4B
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![BU of 6x4b by Molmil](/molmil-images/mine/6x4b) | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-5-fluoro-8-methyl-2-naphthonitrile (JLJ655), a Non-nucleoside Inhibitor | Descriptor: | 7-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-5-fluoro-8-methylnaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | Authors: | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | Deposit date: | 2020-05-22 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
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5W2D
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5W30
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![BU of 5w30 by Molmil](/molmil-images/mine/5w30) | Crystal structure of mutant CJ YCEI protein (CJ-N48C) with monobromobimane guest structure | Descriptor: | 3-(bromomethyl)-2,5,6-trimethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, Putative periplasmic protein, SULFATE ION, ... | Authors: | Huber, T.R, Snow, C.D. | Deposit date: | 2017-06-07 | Release date: | 2018-01-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Installing Guest Molecules at Specific Sites within Scaffold Protein Crystals. Bioconjug. Chem., 29, 2018
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6WPC
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6WU8
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![BU of 6wu8 by Molmil](/molmil-images/mine/6wu8) | Structure of human SHP2 in complex with inhibitor IACS-13909 | Descriptor: | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Leonard, P.G, Joseph, S, Rodenberger, A. | Deposit date: | 2020-05-04 | Release date: | 2021-03-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res., 80, 2020
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7MSK
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![BU of 7msk by Molmil](/molmil-images/mine/7msk) | ThuS glycosin S-glycosyltransferase | Descriptor: | Glyco_trans_2-like domain-containing protein, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE | Authors: | Garg, N, Nair, S.K. | Deposit date: | 2021-05-11 | Release date: | 2022-04-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural and mechanistic investigations of protein S-glycosyltransferases. Cell Chem Biol, 28, 2021
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6WHO
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![BU of 6who by Molmil](/molmil-images/mine/6who) | Histone deacetylases complex with peptide macrocycles | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Histone deacetylase 2, SODIUM ION, ... | Authors: | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | Deposit date: | 2020-04-08 | Release date: | 2021-04-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nat Commun, 12, 2021
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7MSN
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![BU of 7msn by Molmil](/molmil-images/mine/7msn) | SunS glycosin S-glycosyltransferase | Descriptor: | SPbeta prophage-derived glycosyltransferase SunS, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Garg, N, Nair, S.K. | Deposit date: | 2021-05-11 | Release date: | 2022-04-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and mechanistic investigations of protein S-glycosyltransferases. Cell Chem Biol, 28, 2021
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7MSP
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![BU of 7msp by Molmil](/molmil-images/mine/7msp) | SunS glycosin S-glycosyltransferase | Descriptor: | MAGNESIUM ION, SPbeta prophage-derived glycosyltransferase SunS, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Garg, N, Nair, S.K. | Deposit date: | 2021-05-11 | Release date: | 2022-04-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and mechanistic investigations of protein S-glycosyltransferases. Cell Chem Biol, 28, 2021
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6WHN
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![BU of 6whn by Molmil](/molmil-images/mine/6whn) | Histone deacetylases complex with peptide macrocycles | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, Histone deacetylase 2, ... | Authors: | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | Deposit date: | 2020-04-08 | Release date: | 2021-04-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nat Commun, 12, 2021
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6WHQ
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![BU of 6whq by Molmil](/molmil-images/mine/6whq) | Histone deacetylases complex with peptide macrocycles | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Histone deacetylase 2, SODIUM ION, ... | Authors: | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | Deposit date: | 2020-04-08 | Release date: | 2021-04-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nat Commun, 12, 2021
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6WSJ
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5VNP
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7MAE
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![BU of 7mae by Molmil](/molmil-images/mine/7mae) | HIV-1 Protease (I84V) in Complex with PU1 (LR3-46) | Descriptor: | Protease, SULFATE ION, diethyl [(4-{(2S,3R)-4-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-2-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-3-hydroxybutyl}phenoxy)methyl]phosphonate | Authors: | Lockbaum, G.J, Schiffer, C.A. | Deposit date: | 2021-03-31 | Release date: | 2022-04-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.735 Å) | Cite: | HIV-1 Protease in Complex with ligands To Be Published
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5W5K
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![BU of 5w5k by Molmil](/molmil-images/mine/5w5k) | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with KV70 | Descriptor: | 10-{[4-(hydroxycarbamoyl)phenyl]methyl}-5lambda~4~-pyrido[3,2-b][1,4]benzothiazin-10-ium, Histone deacetylase 6, POTASSIUM ION, ... | Authors: | Porter, N.J, Christianson, D.W. | Deposit date: | 2017-06-15 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. J.Med.Chem., 62, 2019
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7MNP
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![BU of 7mnp by Molmil](/molmil-images/mine/7mnp) | Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNK
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![BU of 7mnk by Molmil](/molmil-images/mine/7mnk) | Crystal structure of the tetramerization element of NUP358/RanBP2 (residues 805-832) | Descriptor: | 1,2-ETHANEDIOL, E3 SUMO-protein ligase RanBP2, SULFATE ION | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNJ
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![BU of 7mnj by Molmil](/molmil-images/mine/7mnj) | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) | Descriptor: | E3 SUMO-protein ligase RanBP2 | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Patke, A, Dasso, M, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNR
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![BU of 7mnr by Molmil](/molmil-images/mine/7mnr) | Crystal Structure of the ZnF3 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNU
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![BU of 7mnu by Molmil](/molmil-images/mine/7mnu) | Crystal Structure of the ZnF7 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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