6CQC
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5LR5
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2NVY
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![BU of 2nvy by Molmil](/molmil-images/mine/2nvy) | RNA Polymerase II form II in 150 mM Mn+2 | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ... | Authors: | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | Deposit date: | 2006-11-13 | Release date: | 2006-12-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
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7OM6
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7OM7
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![BU of 7om7 by Molmil](/molmil-images/mine/7om7) | Thosea asigna virus RdRP domain in complex with RNA and nucleotide UMPNPP | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | Authors: | Ferrero, D.S, Falqui, M, Verdaguer, N. | Deposit date: | 2021-05-21 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Snapshots of a Non-Canonical RdRP in Action. Viruses, 13, 2021
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7Q81
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5HZK
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![BU of 5hzk by Molmil](/molmil-images/mine/5hzk) | Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42 | Descriptor: | Cell division control protein 42 homolog, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | Deposit date: | 2016-02-02 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
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7B3D
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![BU of 7b3d by Molmil](/molmil-images/mine/7b3d) | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3) | Descriptor: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase nsp12, ... | Authors: | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | Deposit date: | 2020-11-30 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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5F5F
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![BU of 5f5f by Molmil](/molmil-images/mine/5f5f) | X-ray structure of Roquin ROQ domain in complex with a Selex-derived hexa-loop RNA motif | Descriptor: | RNA (5'-R(P*UP*GP*AP*CP*UP*GP*CP*GP*UP*UP*UP*UP*AP*GP*GP*AP*GP*UP*UP*A)-3'), Roquin-1 | Authors: | Janowski, R, Schlundt, A, Sattler, M, Niessing, D. | Deposit date: | 2015-12-04 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40. Nat Commun, 7, 2016
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7E3R
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![BU of 7e3r by Molmil](/molmil-images/mine/7e3r) | Crystal structure of TrmL from Vibrio vulnificus | Descriptor: | tRNA (cytidine(34)-2'-O)-methyltransferase | Authors: | Kim, J, Son, J. | Deposit date: | 2021-02-09 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of tRNA mehtyltransferase TrmL from Vibrio vulnificus To be published
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5LW5
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2MXJ
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8H0N
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![BU of 8h0n by Molmil](/molmil-images/mine/8h0n) | Crystal structure of the human METTL1-WDR4 complex | Descriptor: | tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 | Authors: | Jin, X.H, Guan, Z.Y, Gong, Z, Zhang, D.L. | Deposit date: | 2022-09-30 | Release date: | 2023-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1. Cell Discov, 9, 2023
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5LWA
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8PTX
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![BU of 8ptx by Molmil](/molmil-images/mine/8ptx) | Cryo-EM structure of human Elp123 in complex with tRNA, acetyl-CoA, 5'-deoxyadenosine and methionine | Descriptor: | 5'-DEOXYADENOSINE, ACETYL COENZYME *A, Elongator complex protein 1, ... | Authors: | Abbassi, N, Jaciuk, M, Lin, T.-Y, Glatt, S. | Deposit date: | 2023-07-16 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Cryo-EM structures of the human Elongator complex at work. Nat Commun, 15, 2024
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6IV6
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![BU of 6iv6 by Molmil](/molmil-images/mine/6iv6) | Cryo-EM structure of AcrVA5-acetylated MbCas12a in complex with crRNA | Descriptor: | RNA (59-MER), nuclease | Authors: | Dong, L, Li, N, Guan, X, Zhu, Y, Gao, N, Huang, Z. | Deposit date: | 2018-12-02 | Release date: | 2019-04-10 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An anti-CRISPR protein disables type V Cas12a by acetylation. Nat. Struct. Mol. Biol., 26, 2019
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6FPT
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![BU of 6fpt by Molmil](/molmil-images/mine/6fpt) | Crystal structure of Danio rerio Lin41 filamin-NHL domains | Descriptor: | E3 ubiquitin-protein ligase TRIM71 | Authors: | Kumari, P, Aeschimann, F, Gaidatzis, D, Keusch, J.J, Ghosh, P, Neagu, A, Pachulska-Wieczorek, K, Bujnicki, J.M, Gut, H, Grosshans, H, Ciosk, R. | Deposit date: | 2018-02-12 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition. Nat Commun, 9, 2018
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7ZOQ
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![BU of 7zoq by Molmil](/molmil-images/mine/7zoq) | Cryo-EM structure of a CRISPR effector in complex with a caspase regulator | Descriptor: | RNA (39-MER), TPR-CHAT, ZINC ION, ... | Authors: | Babatunde, E.E, Davide, T, Bertrand, B, Sergey, N, Alexander, M, Henning, S, Dong, C.N. | Deposit date: | 2022-04-26 | Release date: | 2022-11-30 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the regulation of Cas7-11 by TPR-CHAT. Nat.Struct.Mol.Biol., 30, 2023
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7POF
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4A4D
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![BU of 4a4d by Molmil](/molmil-images/mine/4a4d) | Crystal structure of the N-terminal domain of the Human DEAD-BOX RNA helicase DDX5 (P68) | Descriptor: | PROBABLE ATP-DEPENDENT RNA HELICASE DDX5 | Authors: | Dutta, S, Choi, Y.W, Kotaka, M, Fielding, B.C, Tan, Y.J. | Deposit date: | 2011-10-11 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Variable N-Terminal Region of Ddx5 Contains Structural Elements and Auto-Inhibits its Interaction with Ns5B of Hepatitis C Virus. Biochem.J., 446, 2012
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7MPS
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![BU of 7mps by Molmil](/molmil-images/mine/7mps) | Brucella melitensis NrnC with engaged loop | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NanoRNase C, SULFATE ION | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2021-05-04 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife, 10, 2021
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7MPP
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7MPO
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![BU of 7mpo by Molmil](/molmil-images/mine/7mpo) | Bartonella henselae NrnC bound to pAp | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, NanoRNase C | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2021-05-04 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife, 10, 2021
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7MPQ
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7MPT
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![BU of 7mpt by Molmil](/molmil-images/mine/7mpt) | Brucella melitensis NrnC with bound Mg2+ | Descriptor: | MAGNESIUM ION, NanoRNase C, PHOSPHATE ION | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2021-05-04 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife, 10, 2021
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