8CPR
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![BU of 8cpr by Molmil](/molmil-images/mine/8cpr) | G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer | Descriptor: | GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Moche, M, Jungholm, O, Strandback, E, Ampah-Korsah, H, Nyman, T, Orwar, O. | Deposit date: | 2023-03-03 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A G13D open-state-selective anti-KRAS antibody shows in vivo anti-cancer activity To Be Published
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5J0N
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![BU of 5j0n by Molmil](/molmil-images/mine/5j0n) | Lambda excision HJ intermediate | Descriptor: | Excisionase, Integrase, Integration host factor subunit alpha, ... | Authors: | Van Duyne, G, Grigorieff, N, Landy, A. | Deposit date: | 2016-03-28 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife, 5, 2016
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6EIT
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![BU of 6eit by Molmil](/molmil-images/mine/6eit) | |
6BCN
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![BU of 6bcn by Molmil](/molmil-images/mine/6bcn) | I-LtrI E184D bound to cognate substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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8D3Q
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![BU of 8d3q by Molmil](/molmil-images/mine/8d3q) | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/NoPAM prespacer | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | Deposit date: | 2022-06-01 | Release date: | 2022-11-02 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation. Mol.Cell, 82, 2022
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8D3M
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![BU of 8d3m by Molmil](/molmil-images/mine/8d3m) | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/Processed prespacer | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | Deposit date: | 2022-06-01 | Release date: | 2022-11-02 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation. Mol.Cell, 82, 2022
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8D3L
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![BU of 8d3l by Molmil](/molmil-images/mine/8d3l) | Type I-C Cas4-Cas1-Cas2 complex bound to a PAM/PAM prespacer | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | Deposit date: | 2022-06-01 | Release date: | 2022-11-02 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation. Mol.Cell, 82, 2022
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8D3P
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![BU of 8d3p by Molmil](/molmil-images/mine/8d3p) | Type I-C Cas4-Cas1-Cas2 complex bound to half-site integration intermediate (HSI) | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endonuclease Cas2, CRISPR-associated exonuclease Cas4, ... | Authors: | Dhingra, Y, Suresh, S.K, Juneja, P, Sashital, D.G. | Deposit date: | 2022-06-01 | Release date: | 2022-11-02 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (4.26 Å) | Cite: | PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation. Mol.Cell, 82, 2022
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6BCG
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![BU of 6bcg by Molmil](/molmil-images/mine/6bcg) | I-LtrI A28G bound to cognate substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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6BCF
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![BU of 6bcf by Molmil](/molmil-images/mine/6bcf) | I-LtrI G183A bound to cognate substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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6F3C
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![BU of 6f3c by Molmil](/molmil-images/mine/6f3c) | The cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamer | Descriptor: | DNA (5'-D(*GP*TP*AP*CP*G)-3'), MAGNESIUM ION, [Pt(H2bapbpy)] platinum | Authors: | Ferraroni, M, Bazzicalupi, C, Gratteri, P, Papi, F. | Deposit date: | 2017-11-28 | Release date: | 2019-05-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex. Angew.Chem.Int.Ed.Engl., 58, 2019
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5LWQ
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![BU of 5lwq by Molmil](/molmil-images/mine/5lwq) | CeuE (H227L variant) a periplasmic protein from Campylobacter jejuni | Descriptor: | BROMIDE ION, Enterochelin uptake periplasmic binding protein, SODIUM ION | Authors: | Wilde, E.J, Blagova, E, Hughes, A, Raines, D.J, Moroz, O.V, Turkenburg, J.P, Duhme-Klair, A.-K, Wilson, K.S. | Deposit date: | 2016-09-19 | Release date: | 2017-04-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Interactions of the periplasmic binding protein CeuE with Fe(III) n-LICAM(4-) siderophore analogues of varied linker length. Sci Rep, 7, 2017
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6F6O
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![BU of 6f6o by Molmil](/molmil-images/mine/6f6o) | |
6BCE
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![BU of 6bce by Molmil](/molmil-images/mine/6bce) | Wild-type I-LtrI bound to cognate substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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6BCI
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![BU of 6bci by Molmil](/molmil-images/mine/6bci) | Wild-type I-LtrI bound to non-cognate C4 substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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6BCT
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![BU of 6bct by Molmil](/molmil-images/mine/6bct) | I-LtrI E184D bound to non-cognate C4 substrate (pre-cleavage complex) | Descriptor: | CALCIUM ION, DNA (26-MER), DNA (27-MER), ... | Authors: | Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. | Deposit date: | 2017-10-20 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
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2P89
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![BU of 2p89 by Molmil](/molmil-images/mine/2p89) | |
6K8X
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![BU of 6k8x by Molmil](/molmil-images/mine/6k8x) | Crystal structure of a class C beta lactamase | Descriptor: | Beta-lactamase | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-13 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
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6K98
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![BU of 6k98 by Molmil](/molmil-images/mine/6k98) | Substrates promiscuity of xyloglucanases and endoglucanases of glycoside hydrolase 12 family | Descriptor: | GH12 beta-1, 4-endoglucanase | Authors: | Hong, Y, Tao, T, Pengjun, S, Jiaming, C, Xiaoyu, W, Chen, H, yingguo, B, Bin, Y. | Deposit date: | 2019-06-14 | Release date: | 2020-06-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.032 Å) | Cite: | Substrates promiscuity of xyloglucanases and endoglucanases of glycoside hydrolase 12 family To Be Published
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6K9D
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![BU of 6k9d by Molmil](/molmil-images/mine/6k9d) | glycoside hydrolase family 12 (GH12) englucanase | Descriptor: | GH12 beta-1, 4-endoglucanase | Authors: | Hong, Y, Tao, T, Pengjun, S, Jiaming, C, Xiaoyu, W, Chen, H, Yingguo, B, Bin, Y. | Deposit date: | 2019-06-14 | Release date: | 2020-06-17 | Method: | X-RAY DIFFRACTION (1.505 Å) | Cite: | Substrates promiscuity of xyloglucanases and endoglucanases of glycoside hydrolase 12 family To Be Published
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6K9T
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![BU of 6k9t by Molmil](/molmil-images/mine/6k9t) | Crystal structure of a class C beta-lactamase in complex with cefotaxime | Descriptor: | Beta-lactamase, CEFOTAXIME, C3' cleaved, ... | Authors: | Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2019-06-17 | Release date: | 2019-10-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.459 Å) | Cite: | Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
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7RPC
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![BU of 7rpc by Molmil](/molmil-images/mine/7rpc) | X-ray crystal structure of OXA-24/40 K84D in complex with ertapenem | Descriptor: | (1S,4R,5S,6S)-3-{[(3S,5S)-5-carbamoylpyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... | Authors: | Powers, R.A, Mitchell, J.M, June, C.M. | Deposit date: | 2021-08-03 | Release date: | 2022-07-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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7RPF
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![BU of 7rpf by Molmil](/molmil-images/mine/7rpf) | X-ray crystal structure of OXA-24/40 in complex with doripenem | Descriptor: | (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, ... | Authors: | Powers, R.A, Mitchell, J.M, June, C.M. | Deposit date: | 2021-08-03 | Release date: | 2022-07-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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7RPG
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![BU of 7rpg by Molmil](/molmil-images/mine/7rpg) | X-ray crystal structure of OXA-24/40 K84D in complex with cefotaxime | Descriptor: | Beta-lactamase, CEFOTAXIME, C3' cleaved, ... | Authors: | Powers, R.A, Mitchell, J.M, June, C.M. | Deposit date: | 2021-08-03 | Release date: | 2022-07-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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7RPE
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![BU of 7rpe by Molmil](/molmil-images/mine/7rpe) | X-ray crystal structure of OXA-24/40 in complex with ertapenem | Descriptor: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase, ... | Authors: | Powers, R.A, Mitchell, J.M, June, C.M. | Deposit date: | 2021-08-03 | Release date: | 2022-07-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298, 2022
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