6F3C

The cytotoxic [Pt(H2bapbpy)] platinum complex interacting with the CGTACG hexamer

Summary for 6F3C

• Entry DOI: 10.2210/pdb6f3c/pdb
• Descriptor: DNA (5'-D(*GP*TP*AP*CP*G)-3'), MAGNESIUM ION, [Pt(H2bapbpy)] platinum, ... (5 entities in total)
• Functional Keywords: drug-dna complex, four-way junction, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 4
• Total formula weight: 7753.73

Authors

Ferraroni, M.,Bazzicalupi, C.,Gratteri, P.,Papi, F. (deposition date: 2017-11-28, release date: 2019-05-29, Last modification date: 2024-01-17)

Primary citation

van Rixel, V.H.S.,Busemann, A.,Wissingh, M.F.,Hopkins, S.L.,Siewert, B.,van de Griend, C.,Siegler, M.A.,Marzo, T.,Papi, F.,Ferraroni, M.,Gratteri, P.,Bazzicalupi, C.,Messori, L.,Bonnet, S.
Induction of a Four-Way Junction Structure in the DNA Palindromic Hexanucleotide 5'-d(CGTACG)-3' by a Mononuclear Platinum Complex.
Angew.Chem.Int.Ed.Engl., 58:9378-9382, 2019

PubMed Abstract: Four-way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA-damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5'-d(CGTACG)-3' specifically into a 4WJ-like motif. In the crystal structure of the 1-CGTACG adduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through π-π stacking and hydrogen bonding, without forming any platinum-nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.

PubMed: 31046177
DOI: 10.1002/anie.201814532

Experimental method

X-RAY DIFFRACTION (2.3 Å)