2OS3
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![BU of 2os3 by Molmil](/molmil-images/mine/2os3) | Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes | Descriptor: | ACTINONIN, COBALT (II) ION, Peptide deformylase | Authors: | Kim, E.E, Kim, K.-H, Moon, J.H, Choi, K, Lee, H.K, Parh, H.S. | Deposit date: | 2007-02-05 | Release date: | 2008-03-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes To be Published
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6AEG
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![BU of 6aeg by Molmil](/molmil-images/mine/6aeg) | Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM) | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*GP*AP*TP*TP*AP*TP*TP*G)-3'), DNA nuclease, ... | Authors: | Guo, M, Ren, K, Zhu, Y, Huang, Z. | Deposit date: | 2018-08-04 | Release date: | 2019-03-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
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5FW2
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![BU of 5fw2 by Molmil](/molmil-images/mine/5fw2) | Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.676 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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6AI6
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![BU of 6ai6 by Molmil](/molmil-images/mine/6ai6) | Crystal structure of SpCas9-NG | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | Authors: | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-21 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Engineered CRISPR-Cas9 nuclease with expanded targeting space Science, 361, 2018
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6AEB
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![BU of 6aeb by Molmil](/molmil-images/mine/6aeb) | Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM) | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*AP*AP*GP*TP*AP*TP*TP*G)-3'), DNA Nuclease, ... | Authors: | Guo, M, Ren, K, Zhu, Y, Huang, Z. | Deposit date: | 2018-08-04 | Release date: | 2019-03-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
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5F2M
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![BU of 5f2m by Molmil](/molmil-images/mine/5f2m) | |
5FQ5
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![BU of 5fq5 by Molmil](/molmil-images/mine/5fq5) | Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M. | Deposit date: | 2015-12-07 | Release date: | 2016-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.136 Å) | Cite: | Data-Collection Strategy for Challenging Native Sad Phasing. Acta Crystallogr.,Sect.D, 72, 2016
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5FW1
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![BU of 5fw1 by Molmil](/molmil-images/mine/5fw1) | Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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4NU0
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![BU of 4nu0 by Molmil](/molmil-images/mine/4nu0) | Crystal structure of Adenylate kinase from Streptococcus pneumoniae with Ap5A | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION | Authors: | Thach, T.T, Luong, T.T, Lee, S.H, Rhee, D.K. | Deposit date: | 2013-12-03 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.485 Å) | Cite: | Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity FEBS Open Bio, 4, 2014
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1LM6
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![BU of 1lm6 by Molmil](/molmil-images/mine/1lm6) | Crystal Structure of Peptide Deformylase from Streptococcus pneumoniae | Descriptor: | FE (III) ION, GLYCEROL, peptide deformylase DEFB | Authors: | Kreusch, A, Spraggon, G, Lee, C.C, Klock, H, McMullan, D, Ng, K, Shin, T, Vincent, J, Warner, I, Ericson, C, Lesley, S.A. | Deposit date: | 2002-04-30 | Release date: | 2003-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure analysis of peptide deformylases from streptococcus pneumoniae,staphylococcus aureus, thermotoga maritima, and pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase J.MOL.BIOL., 330, 2003
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3S46
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![BU of 3s46 by Molmil](/molmil-images/mine/3s46) | The crystal structure of alanine racemase from streptococcus pneumoniae | Descriptor: | Alanine racemase, BENZOIC ACID | Authors: | Im, H, Sharpe, M.L, Strych, U, Davlieva, M, Krause, K.L. | Deposit date: | 2011-05-18 | Release date: | 2011-06-22 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. BMC MICROBIOL., 11, 2011
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2OHV
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![BU of 2ohv by Molmil](/molmil-images/mine/2ohv) | Structural Basis for Glutamate Racemase Inhibition | Descriptor: | (4S)-4-(2-NAPHTHYLMETHYL)-D-GLUTAMIC ACID, Glutamate Racemase | Authors: | Kim, E.E. | Deposit date: | 2007-01-10 | Release date: | 2007-09-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for glutamate racemase inhibition J.Mol.Biol., 372, 2007
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7VK9
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![BU of 7vk9 by Molmil](/molmil-images/mine/7vk9) | Crystal structure of xCas9 P411T | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1 | Authors: | Bao, R, Liu, H.Y, Luo, Y.Z, Song, Y.J. | Deposit date: | 2021-09-29 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and Dynamics Studies of the Spcas9 Variant Provide Insights into the Regulatory Role of the REC1 Domain Acs Catalysis, 12, 2022
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7QQR
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![BU of 7qqr by Molmil](/molmil-images/mine/7qqr) | SpCas9 bound to AAVS1 off-target5 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target5 non-target strand, AAVS1 off-target5 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQV
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![BU of 7qqv by Molmil](/molmil-images/mine/7qqv) | SpCas9 bound to FANCF off-target3 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target3 non-target strand, FANCF off-target3 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR5
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![BU of 7qr5 by Molmil](/molmil-images/mine/7qr5) | SpCas9 bound to FANCF off-target6 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target6 non-target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-17 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQO
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![BU of 7qqo by Molmil](/molmil-images/mine/7qqo) | SpCas9 bound to AAVS1 off-target1 DNA substrate | Descriptor: | AAVS1 off-target1 non-target strand, AAVS1 off-target1 target strand, AAVS1 sgRNA, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQQ
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![BU of 7qqq by Molmil](/molmil-images/mine/7qqq) | SpCas9 bound to AAVS1 off-target4 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target4 non-target strand, AAVS1 off-target4 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQU
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![BU of 7qqu by Molmil](/molmil-images/mine/7qqu) | SpCas9 bound to FANCF off-target2 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target2 non-target strand, FANCF off-target2 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQT
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![BU of 7qqt by Molmil](/molmil-images/mine/7qqt) | SpCas9 bound to FANCF off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target1 non-target strand, FANCF off-target1 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR8
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![BU of 7qr8 by Molmil](/molmil-images/mine/7qr8) | SpCas9 bound to PTPRC off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQP
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![BU of 7qqp by Molmil](/molmil-images/mine/7qqp) | SpCas9 bound to AAVS1 off-target3 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target3 non-target strand, AAVS1 off-target3 target strand, ... | Authors: | Pacesa, M, JInek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQS
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![BU of 7qqs by Molmil](/molmil-images/mine/7qqs) | SpCas9 bound to FANCF on-target DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF on-target non-target strand, FANCF on-target target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQX
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![BU of 7qqx by Molmil](/molmil-images/mine/7qqx) | SpCas9 bound to FANCF off-target5 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target5 non-target strand, FANCF off-target5 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR0
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![BU of 7qr0 by Molmil](/molmil-images/mine/7qr0) | SpCas9 bound to TRAC off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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