2KVF
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2KVG
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7RCF
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7RCG
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7RCD
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7RCE
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7RCC
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6RJG
| Cryo-EM structure of St1Cas9-sgRNA-AcrIIA6-tDNA59-ntPAM complex. | Descriptor: | AcrIIA6, Cas 9, ntPAM, ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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8GJ9
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1EEK
| SOLUTION STRUCTURE OF A NONPOLAR, NON HYDROGEN BONDED BASE PAIR SURROGATE IN DNA. | Descriptor: | 5'-D(*CP*GP*CP*AP*TP*(DFT)P*GP*TP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*AP*CP*(MBZ)P*AP*TP*GP*CP*G)-3' | Authors: | Kool, E.T, Krugh, T.R, Guckian, K.M. | Deposit date: | 2000-02-01 | Release date: | 2000-02-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA J.Am.Chem.Soc., 122, 2000
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7VIM
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2DPU
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3FA1
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5NRR
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8A3V
| Crystal structure of the Vibrio cholerae replicative helicase (VcDnaB) in complex with its loader protein (VcDciA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DUF721 domain-containing protein, MAGNESIUM ION, ... | Authors: | Walbott, H, Quevillon-Cheruel, S, Cargemel, C. | Deposit date: | 2022-06-09 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The LH-DH module of bacterial replicative helicases is the common binding site for DciA and other helicase loaders. Acta Crystallogr D Struct Biol, 79, 2023
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5NRV
| Human DNMT3B PWWP domain in complex with 6-dipropylamino-1-hexanol | Descriptor: | 6-dipropylamino-1-hexanol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-04-25 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.075 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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7T5V
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7T5W
| Structure of E. coli CapH C-terminal domain | Descriptor: | Helix-turn-helix domain-containing protein | Authors: | Lau, R.K, Corbett, K.D. | Deposit date: | 2021-12-13 | Release date: | 2022-09-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage. Embo J., 41, 2022
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5NRS
| Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine | Descriptor: | (2~{S})-1-[2-hydroxyethyl-[(2~{S})-2-oxidanylpropyl]amino]propan-2-ol, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-04-25 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To be published
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4FDG
| Crystal Structure of an Archaeal MCM Filament | Descriptor: | Minichromosome maintenance protein MCM, ZINC ION | Authors: | Slaymaker, I.M, Fu, Y, Brewster, A.B, Chen, X.S. | Deposit date: | 2012-05-28 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. Nucleic Acids Res., 41, 2013
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8QG0
| Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 17 nt RNA guide and 17 nt DNA target | Descriptor: | AfAgo-N protein, DNA target 17 nt, Piwi protein, ... | Authors: | Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Zagorskaite, E, Silanskas, A. | Deposit date: | 2023-09-05 | Release date: | 2024-01-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
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5NV0
| Human DNMT3B PWWP domain in complex with 4-(dipropylamino)butyronitrile | Descriptor: | 4-(dipropylamino)butanenitrile, DNA (cytosine-5)-methyltransferase 3B, SULFATE ION | Authors: | Rondelet, G, Wouters, J. | Deposit date: | 2017-05-03 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors To Be Published
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5DQU
| Crystal Structure of Cas-DNA-10 complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(*GP*AP*GP*TP*CP*GP*AP*TP*GP*CP*TP*TP*TP*TP*T)-3'), ... | Authors: | Wang, J, Li, J, Zhao, H, Sheng, G, Wang, M, Yin, M, Wang, Y. | Deposit date: | 2015-09-15 | Release date: | 2015-11-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell, 163, 2015
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8WRX
| Anti-CRISPR type II-A 28 | Descriptor: | Anti-CRISPR protein AcrIIA28, ZINC ION | Authors: | Kim, G.E, Park, H.H. | Deposit date: | 2023-10-16 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | AcrIIA28 is a metalloprotein that specifically inhibits targeted-DNA loading to SpyCas9 by binding to the REC3 domain. Nucleic Acids Res., 52, 2024
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6RJD
| Cryo-EM structure of St1Cas9-sgRNA-tDNA59-ntPAM complex. | Descriptor: | Streptococcus Thermophilus 1 Cas9, ntPAM, sgRNA (78-MER), ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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