8T3M
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![BU of 8t3m by Molmil](/molmil-images/mine/8t3m) | TRPV1 in nanodisc bound with 3 LPA molecules | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T3L
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![BU of 8t3l by Molmil](/molmil-images/mine/8t3l) | TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-07 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T1F
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![BU of 8t1f by Molmil](/molmil-images/mine/8t1f) | Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1E
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![BU of 8t1e by Molmil](/molmil-images/mine/8t1e) | Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | Descriptor: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1D
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![BU of 8t1d by Molmil](/molmil-images/mine/8t1d) | Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | Descriptor: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1C
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![BU of 8t1c by Molmil](/molmil-images/mine/8t1c) | Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | Authors: | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1B
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![BU of 8t1b by Molmil](/molmil-images/mine/8t1b) | Cryo-EM structure of full-length human TRPV4 in apo state | Descriptor: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | Authors: | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T10
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![BU of 8t10 by Molmil](/molmil-images/mine/8t10) | TRPV1 in nanodisc bound with two LPA molecules in opposite monomers | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0Y
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![BU of 8t0y by Molmil](/molmil-images/mine/8t0y) | TRPV1 in nanodisc bound with one LPA in one monomer | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-06-01 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0E
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![BU of 8t0e by Molmil](/molmil-images/mine/8t0e) | TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo) | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Cheng, Y. | Deposit date: | 2023-05-31 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0C
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![BU of 8t0c by Molmil](/molmil-images/mine/8t0c) | |
8SRK
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![BU of 8srk by Molmil](/molmil-images/mine/8srk) | Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of Ca and ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRJ
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![BU of 8srj by Molmil](/molmil-images/mine/8srj) | |
8SRI
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![BU of 8sri by Molmil](/molmil-images/mine/8sri) | Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRH
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![BU of 8srh by Molmil](/molmil-images/mine/8srh) | Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRG
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![BU of 8srg by Molmil](/molmil-images/mine/8srg) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRF
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![BU of 8srf by Molmil](/molmil-images/mine/8srf) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRE
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![BU of 8sre by Molmil](/molmil-images/mine/8sre) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRD
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![BU of 8srd by Molmil](/molmil-images/mine/8srd) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRC
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![BU of 8src by Molmil](/molmil-images/mine/8src) | Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SRB
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![BU of 8srb by Molmil](/molmil-images/mine/8srb) | Cryo-EM structure of TRPM2 chanzyme in the presence of EDTA and ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, TRPM2 chanzyme | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SRA
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![BU of 8sra by Molmil](/molmil-images/mine/8sra) | Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium | Descriptor: | CALCIUM ION, CHOLESTEROL, TRPM2 chanzyme | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SR9
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![BU of 8sr9 by Molmil](/molmil-images/mine/8sr9) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium | Descriptor: | CHOLESTEROL, MAGNESIUM ION, TRPM2 chanzyme | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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8SR8
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![BU of 8sr8 by Molmil](/molmil-images/mine/8sr8) | |
8SR7
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![BU of 8sr7 by Molmil](/molmil-images/mine/8sr7) | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (1.97 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Nat.Struct.Mol.Biol., 2024
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