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7XUD
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BU of 7xud by Molmil
Structure of G9a in complex with compound 26a
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T.
Deposit date:2022-05-18
Release date:2023-03-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
J.Med.Chem., 66, 2023
7XUB
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BU of 7xub by Molmil
Structure of G9a in complex with compound 10d
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase EHMT2, ...
Authors:Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T.
Deposit date:2022-05-18
Release date:2023-03-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
J.Med.Chem., 66, 2023
7XUA
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BU of 7xua by Molmil
Structure of G9a in complex with compound 10a
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase EHMT2, ...
Authors:Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T.
Deposit date:2022-05-18
Release date:2023-03-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
J.Med.Chem., 66, 2023
7XUC
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BU of 7xuc by Molmil
Structure of G9a in complex with compound 11a
Descriptor: 1,2-ETHANEDIOL, 3,6,6-trimethyl-4-oxidanylidene-~{N}-[(2~{S})-1-oxidanylidene-1-phenylazanyl-hexan-2-yl]-5,7-dihydro-1~{H}-indole-2-carboxamide, CHLORIDE ION, ...
Authors:Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Umehara, T.
Deposit date:2022-05-18
Release date:2023-03-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
J.Med.Chem., 66, 2023
6ASZ
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BU of 6asz by Molmil
Chromodomain HP1 with Y24F mutation bound to histone H3 peptide containing trimethyl lysine
Descriptor: Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide
Authors:Brustad, E.M, Baril, S.A, Waters, M.L.
Deposit date:2017-08-27
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.518 Å)
Cite:Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis.
J. Am. Chem. Soc., 139, 2017
5YY9
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BU of 5yy9 by Molmil
Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3
Descriptor: E3 ubiquitin-protein ligase UHRF1, Ligase 1
Authors:Kori, S, Defossez, P.A, Arita, K.
Deposit date:2017-12-08
Release date:2018-12-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.653 Å)
Cite:Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
Structure, 27, 2019
6AT0
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BU of 6at0 by Molmil
Chromodomain HP1 with a p-nitro-L-phenylalanine mutation at position 24 bound to histone H3 peptide containing trimethyl lysine
Descriptor: Heterochromatin protein 1, trimethyl lysine histone H3 tail peptide
Authors:Brustad, E.M, Baril, S.A, Waters, M.L.
Deposit date:2017-08-27
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.285 Å)
Cite:Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis.
J. Am. Chem. Soc., 139, 2017
6A5M
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BU of 6a5m by Molmil
Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 2
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, S-ADENOSYLMETHIONINE, ...
Authors:Li, X, Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5N
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BU of 6a5n by Molmil
Crystal structure of Arabidopsis thaliana SUVH6 in complex with methylated DNA
Descriptor: DNA (5'-D(*CP*AP*CP*TP*GP*CP*TP*GP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*GP*AP*GP*TP*AP*CP*TP*(5CM)P*AP*GP*CP*AP*GP*T)-3'), Histone-lysine N-methyltransferase, ...
Authors:Li, X, Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5K
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BU of 6a5k by Molmil
Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 1
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, S-ADENOSYLMETHIONINE, ...
Authors:Li, X, Du, J.
Deposit date:2018-06-24
Release date:2018-08-29
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YYA
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BU of 5yya by Molmil
Crystal structure of Tandem Tudor Domain of human UHRF1
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION
Authors:Kori, S, Defossez, P.A, Arita, K.
Deposit date:2017-12-08
Release date:2018-12-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
Structure, 27, 2019
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数据于2025-07-09公开中

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