7XUB

Structure of G9a in complex with compound 10d

Summary for 7XUB

• Entry DOI: 10.2210/pdb7xub/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT2, ZINC ION, SINEFUNGIN, ... (7 entities in total)
• Functional Keywords: histone lysine methyltransferase, inhibitor, protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 67617.28

Authors

Niwa, H.,Shirai, F.,Sato, S.,Nishigaya, Y.,Umehara, T. (deposition date: 2022-05-18, release date: 2023-03-29, Last modification date: 2023-11-29)

• Primary citation: Nishigaya, Y.,Takase, S.,Sumiya, T.,Kikuzato, K.,Sato, T.,Niwa, H.,Sato, S.,Nakata, A.,Sonoda, T.,Hashimoto, N.,Namie, R.,Honma, T.,Umehara, T.,Shirouzu, M.,Koyama, H.,Yoshida, M.,Ito, A.,Shirai, F.; Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.; J.Med.Chem., 66:4059-4085, 2023; PubMed: 36882960; DOI: 10.1021/acs.jmedchem.2c02059

Experimental method

X-RAY DIFFRACTION (2 Å)