9C83
| X-ray crystal structure of AmpC beta-lactamase with inhibitor | Descriptor: | AmpC Beta-lactamase, N-[(3M)-3-(5-chloro-1,2,3-thiadiazol-4-yl)phenyl]-5-methyl-3-oxo-2,3-dihydro-1,2-oxazole-4-sulfonamide | Authors: | Liu, F, Shoichet, B.K. | Deposit date: | 2024-06-11 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
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1FB5
| LOW RESOLUTION STRUCTURE OF OVINE ORNITHINE TRANSCARBMOYLASE IN THE UNLIGANDED STATE | Descriptor: | NORVALINE, ORNITHINE TRANSCARBAMOYLASE | Authors: | Zanotti, G, Battistutta, R, Panzalorto, M, Francescato, P, Bruno, G, De Gregorio, A. | Deposit date: | 2000-07-14 | Release date: | 2003-08-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Functional and structural characterization of ovine ornithine transcarbamoylase. Org.Biomol.Chem., 1, 2003
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2AIJ
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9C84
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2AIK
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1CS1
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4E1V
| X-RAY Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with 5-Fluorouracil at 2.15 A Resolution | Descriptor: | 1,2-ETHANEDIOL, 5-FLUOROURACIL, GLYCEROL, ... | Authors: | Lashkov, A.A, Sotnichenko, S.E, Prokofev, I.I, Gabdoulkhakov, A.G, Mikhailov, A.M. | Deposit date: | 2012-03-07 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae. Acta Crystallogr.,Sect.D, 68, 2012
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9C6P
| X-ray crystal structure of AmpC beta-lactamase with inhibitor | Descriptor: | 3-chloro-N-(5-chloro-2-methyl-1,3-benzothiazol-6-yl)-2-hydroxybenzene-1-sulfonamide, AmpC Beta-lactamase | Authors: | Liu, F, Shoichet, B.K. | Deposit date: | 2024-06-08 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.663 Å) | Cite: | Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
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1KKX
| Solution structure of the DNA-binding domain of ADR6 | Descriptor: | Transcription regulatory protein ADR6 | Authors: | Tu, X, Wu, J, Xu, Y, Shi, Y. | Deposit date: | 2001-12-10 | Release date: | 2002-07-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments and secondary structure of ADR6 DNA-binding domain. J.Biomol.Nmr, 21, 2001
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1BXN
| THE CRYSTAL STRUCTURE OF RUBISCO FROM ALCALIGENES EUTROPHUS TO 2.7 ANGSTROMS. | Descriptor: | PHOSPHATE ION, PROTEIN (RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN), PROTEIN (RIBULOSE BISPHOSPHATE CARBOXYLASE SMALL CHAIN) | Authors: | Hansen, S, Vollan, V.B, Hough, E, Andersen, K. | Deposit date: | 1998-10-06 | Release date: | 1999-10-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of rubisco from Alcaligenes eutrophus reveals a novel central eight-stranded beta-barrel formed by beta-strands from four subunits. J.Mol.Biol., 288, 1999
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6ETF
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6ETH
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6C2C
| The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ZINC ION, ... | Authors: | Hong, N.-S, Jackson, C.J, Carr, P.D, Tokuriki, N, Baier, F, Yang, G. | Deposit date: | 2018-01-08 | Release date: | 2019-01-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.597 Å) | Cite: | Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme. Nat.Chem.Biol., 15, 2019
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2PEL
| PEANUT LECTIN | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PEANUT LECTIN, ... | Authors: | Banerjee, R, Das, K, Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | Deposit date: | 1995-08-23 | Release date: | 1996-12-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex. J.Mol.Biol., 259, 1996
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4GLJ
| Crystal structure of methylthioadenosine phosphorylase in complex with rhodamine B | Descriptor: | CHLORIDE ION, N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium, PHOSPHATE ION, ... | Authors: | Bujacz, A, Bujacz, G, Cieslinski, H, Bartasun, P. | Deposit date: | 2012-08-14 | Release date: | 2013-02-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A study on the interaction of rhodamine B with methylthioadenosine phosphorylase protein sourced from an antarctic soil metagenomic library. Plos One, 8, 2013
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1EC2
| HIV-1 protease in complex with the inhibitor BEA428 | Descriptor: | HIV-1 PROTEASE, N,N-[2,5-O-[DI-4-PYRIDIN-3-YL-BENZYL]-GLUCARYL]-DI-[VALYL-AMIDO-METHANE] | Authors: | Unge, T. | Deposit date: | 2000-01-25 | Release date: | 2002-06-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors Eur.J.Biochem., 270, 2003
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2X7N
| Mechanism of eIF6s anti-association activity | Descriptor: | 60S RIBOSOMAL PROTEIN L23, 60S RIBOSOMAL PROTEIN L24-A, EUKARYOTIC TRANSLATION INITIATION FACTOR 6, ... | Authors: | Gartmann, M, Blau, M, Armache, J.-P, Mielke, T, Topf, M, Beckmann, R. | Deposit date: | 2010-03-02 | Release date: | 2010-03-31 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (11.8 Å) | Cite: | Mechanism of Eif6-Mediated Inhibition of Ribosomal Subunit Joining. J.Biol.Chem., 285, 2010
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1EC0
| HIV-1 protease in complex with the inhibitor bea403 | Descriptor: | HIV-1 PROTEASE, N,N-[2,5-O-DI-2-FLUORO-BENZYL-GLUCARYL]-DI-[1-AMINO-INDAN-2-OL] | Authors: | Unge, T. | Deposit date: | 2000-01-25 | Release date: | 2002-06-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy Eur.J.Biochem., 271, 2004
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3X1J
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3X1M
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1CGL
| Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor | Descriptor: | CALCIUM ION, FIBROBLAST COLLAGENASE, N-[(1S)-3-{[(benzyloxy)carbonyl]amino}-1-carboxypropyl]-L-leucyl-N-(2-morpholin-4-ylethyl)-L-phenylalaninamide, ... | Authors: | Lovejoy, B, Cleasby, A, Hassell, A.M, Longley, K, Luther, M.A, Weigl, D, Mcgeehan, G, Mcelroy, A.B, Drewry, D, Lambert, M.H, Jordan, S.R. | Deposit date: | 1993-11-17 | Release date: | 1995-02-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science, 263, 1994
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4HXW
| Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | Descriptor: | (3R)-1-[5-chloro-6-ethyl-2-(pyrido[2,3-b]pyrazin-7-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrrolidin-3-amine, DNA gyrase subunit B, TERTIARY-BUTYL ALCOHOL | Authors: | Bensen, D.C, Trzoss, M, Tari, L.W. | Deposit date: | 2012-11-12 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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3X1K
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1CLX
| CATALYTIC CORE OF XYLANASE A | Descriptor: | CALCIUM ION, XYLANASE A | Authors: | Harris, G.W, Jenkins, J.A, Connerton, I, Pickersgill, R.W. | Deposit date: | 1995-08-31 | Release date: | 1996-06-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Refined crystal structure of the catalytic domain of xylanase A from Pseudomonas fluorescens at 1.8 A resolution. Acta Crystallogr.,Sect.D, 52, 1996
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4NI3
| Crystal Structure of GH29 family alpha-L-fucosidase from Fusarium graminearum in the closed form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-fucosidase GH29, ... | Authors: | Cao, H, Walton, J.D, Brumm, P, Phillips Jr, G.N. | Deposit date: | 2013-11-05 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.3993 Å) | Cite: | Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum. J.Biol.Chem., 289, 2014
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