8YNA
 
 | | Cryo-EM structure of histamine H4 receptor in complex with immepip and Gi | | Descriptor: | 4-(1H-imidazol-5-ylmethyl)piperidine, Antibody fragment scFv16, CHOLESTEROL, ... | | Authors: | Zhang, X, Liu, G, Li, X, Gong, W. | | Deposit date: | 2024-03-10 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Structural basis of ligand recognition and activation of the histamine receptor family.
Nat Commun, 15, 2024
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8XP3
 | | Cryo-EM structure of the human 40S ribosome with LARP1 and LRRC47 | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Huang, Z, Ye, X, Li, Y, Cheng, J. | | Deposit date: | 2024-01-02 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | LARP1 binds ribosomes and TOP mRNAs in repressed complexes.
Embo J., 43, 2024
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8XP2
 | | Cryo-EM structure of the human 40S ribosome with LARP1 | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Huang, Z, Ye, X, Li, Y, Cheng, J. | | Deposit date: | 2024-01-02 | | Release date: | 2024-11-20 | | Last modified: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | LARP1 binds ribosomes and TOP mRNAs in repressed complexes.
Embo J., 43, 2024
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3UFR
 | | Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(((E)-5-(3-fluorophenyl)pent-4-en-1-yl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-{[(3E)-4-(3-fluorophenyl)but-3-en-1-yl]oxy}pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2011-11-01 | | Release date: | 2012-07-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J.Am.Chem.Soc., 134, 2012
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8XYD
 | | Structure of Platelet-activating factor receptor-G protein complex bound to platelet-activating factor | | Descriptor: | (2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Fan, W, Xu, Y, Zhuang, Y, Xu, H.E. | | Deposit date: | 2024-01-19 | | Release date: | 2024-11-13 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular basis for the activation of PAF receptor by PAF.
Cell Rep, 43, 2024
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8XKS
 | | The cryo-EM structure of Orf2971-FtsHi motor complex | | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 4Fe-4S ferredoxin-type domain-containing protein, ... | | Authors: | Wang, N, Li, M. | | Deposit date: | 2023-12-24 | | Release date: | 2024-12-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Architecture of the ATP-driven motor for protein import into chloroplasts.
Mol Plant, 17, 2024
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8Y45
 | | Cryo-EM structure of opioid receptor with biased agonist | | Descriptor: | Delta-type opioid receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Lin, C, Chang, Z. | | Deposit date: | 2024-01-30 | | Release date: | 2024-11-27 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Cryo-EM structure of small-molecule agonist bound delta opioid receptor-G i complex enables discovery of biased compound.
Nat Commun, 15, 2024
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3UFT
 | | Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(4-(3-chloro-5-fluorophenoxy)butoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-({(3R,4R)-4-[4-(3-chloro-5-fluorophenoxy)butoxy]pyrrolidin-3-yl}methyl)-4-methylpyridin-2-amine, ACETATE ION, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2011-11-01 | | Release date: | 2012-07-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.078 Å) | | Cite: | Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J.Am.Chem.Soc., 134, 2012
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3UT5
 | | Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ranaivoson, F.M, Gigant, B, Knossow, M. | | Deposit date: | 2011-11-25 | | Release date: | 2012-08-01 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Structural plasticity of tubulin assembly probed by vinca-domain ligands.
Acta Crystallogr.,Sect.D, 68, 2012
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8XU8
 | | State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-01-12 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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3UFW
 | | Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-((5-(6-aminopyridin-2-yl)pentyl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-{[5-(6-aminopyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2011-11-01 | | Release date: | 2012-07-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J.Am.Chem.Soc., 134, 2012
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8ZR5
 | | Cryo-EM Structure of GPR119-Gs-Firuglipel complex | | Descriptor: | 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y. | | Deposit date: | 2024-06-04 | | Release date: | 2024-06-19 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Cryo-EM structure of GPR119-Gs complex
To Be Published
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8ZRK
 | | Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263 | | Descriptor: | GSK-1292263, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wong, T.S, Xiong, T.T, Zeng, Z.C, Gan, S.Y, Qiu, C, Du, Y. | | Deposit date: | 2024-06-04 | | Release date: | 2024-06-19 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Cryo-EM structure of GPR119-Gs complex
To be published
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8ZH8
 | | Human GPR103 -Gq complex bound to QRFP26 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O. | | Deposit date: | 2024-05-10 | | Release date: | 2024-07-03 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
Nat Commun, 15, 2024
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8ZJD
 | | Cryo-EM structure of kisspeptin receptor bound to KP-10 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Shen, S, Liu, H, Xu, H.E. | | Deposit date: | 2024-05-14 | | Release date: | 2024-07-03 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.
Cell Rep, 43, 2024
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8ZSP
 | | Cryo-EM structure of the LSD-bound hTAAR1-Gs complex | | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-05 | | Release date: | 2024-07-24 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
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8ZQE
 | | Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex | | Descriptor: | GPR15, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, Z.Y, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-02 | | Release date: | 2024-07-10 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15.
Cell Discov, 10, 2024
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8ZSV
 | | Cryo-EM structure of the RO5263397-bound mTAAR1-Gs complex | | Descriptor: | (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-05 | | Release date: | 2024-07-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
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8ZSS
 | | Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex | | Descriptor: | (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-05 | | Release date: | 2024-07-24 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
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8ZSJ
 | | Cryo-EM structure of the apo hTAAR1-Gs complex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-05 | | Release date: | 2024-07-24 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
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8ZDB
 | | Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3 | | Descriptor: | 18S rRNA, Serine/threonine-protein kinase RIO3, Small ribosomal subunit protein RACK1, ... | | Authors: | Huang, Z, Wang, M, Li, Y, Beckmann, R, Cheng, J. | | Deposit date: | 2024-05-01 | | Release date: | 2025-02-12 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | RIOK3 mediates the degradation of 40S ribosomes.
Mol.Cell, 85, 2025
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8ZDD
 | | Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 (without NOB1) | | Descriptor: | 18S rRNA, Pre-rRNA-processing protein TSR1 homolog, Protein LTV1 homolog, ... | | Authors: | Huang, Z, Wang, M, Li, Y, Beckmann, R, Cheng, J. | | Deposit date: | 2024-05-01 | | Release date: | 2025-02-12 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | RIOK3 mediates the degradation of 40S ribosomes.
Mol.Cell, 85, 2025
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8ZFC
 | | Cryo-EM structure of the mmGPR4-Gs complex in pH7.6 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wen, X, Rong, N.K, Yang, F, Sun, J.P. | | Deposit date: | 2024-05-07 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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8ZFA
 | | Cryo-EM structure of the xtGPR4-Gs complex in pH7.2 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rong, N.K, Wen, X, Yang, F, Sun, J.P. | | Deposit date: | 2024-05-07 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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8ZF9
 | | Cryo-EM structure of the mmGPR4-Gs complex in pH7.2 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wen, X, Rong, N.K, Yang, F, Sun, J.P. | | Deposit date: | 2024-05-07 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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