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3H6K
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BU of 3h6k by Molmil
Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor
Descriptor: 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bard, J, Svenson, K.
Deposit date:2009-04-23
Release date:2009-12-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52, 2009
5KUT
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BU of 5kut by Molmil
hMiro2 C-terminal GTPase domain, GDP-bound
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitochondrial Rho GTPase 2
Authors:Klosowiak, J.L, Focia, P.J, Rice, S.E, Freymann, D.M.
Deposit date:2016-07-13
Release date:2016-09-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.693 Å)
Cite:Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Sci Rep, 6, 2016
1X1X
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BU of 1x1x by Molmil
Water-mediate interaction at aprotein-protein interface
Descriptor: Barstar, Ribonuclease
Authors:Ikura, T, Urakubo, Y, Ito, N.
Deposit date:2005-04-15
Release date:2005-04-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Water-mediated interaction at a protein-protein interface
Chem.Phys., 307, 2004
1E94
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BU of 1e94 by Molmil
HslV-HslU from E.coli
Descriptor: HEAT SHOCK PROTEIN HSLU, HEAT SHOCK PROTEIN HSLV, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Song, H.K, Hartmann, C, Ravishankar, R, Bochtler, M.
Deposit date:2000-10-07
Release date:2000-11-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutational Studies on Hslu and its Docking Mode with Hslv
Proc.Natl.Acad.Sci.USA, 97, 2000
1U3V
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BU of 1u3v by Molmil
Crystal Structure of Human Alcohol Dehydrogenase Beta-1-Beta-1 Isoform Complexed with N-Heptylformamide Determined to 1.65 Angstrom Resolution
Descriptor: Alcohol dehydrogenase beta chain, HEPTYLFORMAMIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Gibbons, B.J, Hurley, T.D.
Deposit date:2004-07-23
Release date:2004-10-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors
Biochemistry, 43, 2004
8XBS
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BU of 8xbs by Molmil
C. elegans apo-SID1 structure
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gong, D.S.
Deposit date:2023-12-07
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.21 Å)
Cite:Structural basis for double-stranded RNA recognition by SID1.
Nucleic Acids Res., 52, 2024
8XC1
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BU of 8xc1 by Molmil
C. elegans SID1 in complex with dsRNA
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gong, D.S.
Deposit date:2023-12-07
Release date:2024-06-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.21 Å)
Cite:Structural basis for double-stranded RNA recognition by SID1.
Nucleic Acids Res., 52, 2024
6NKQ
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BU of 6nkq by Molmil
The structure of bovine beta-lactoglobulin in novel crystals grown at pH 3.8
Descriptor: Beta-lactoglobulin, CALCIUM ION
Authors:McPherson, A.
Deposit date:2019-01-07
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of bovine beta-lactoglobulin in crystals grown at pH 3.8 exhibiting novel threefold twinning.
Acta Crystallogr.,Sect.F, 75, 2019
8XGB
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BU of 8xgb by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
Descriptor: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
2ZH2
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BU of 2zh2 by Molmil
Complex structure of AFCCA with tRNAminiDAC
Descriptor: CCA-adding enzyme, SULFATE ION, tRNA (34-MER)
Authors:Toh, Y, Tomita, K.
Deposit date:2008-02-01
Release date:2008-08-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme
Embo J., 27, 2008
1EQW
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BU of 1eqw by Molmil
CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM CU,ZN SUPEROXIDE DISMUTASE
Descriptor: COPPER (II) ION, CU,ZN SUPEROXIDE DISMUTASE, ZINC ION
Authors:Pesce, A, Battistoni, A, Stroppolo, M.E, Polizio, F, Nardini, M, Kroll, J.S, Langford, P.R, O'Neill, P, Sette, M, Desideri, A, Bolognesi, M.
Deposit date:2000-04-06
Release date:2000-09-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Functional and crystallographic characterization of Salmonella typhimurium Cu,Zn superoxide dismutase coded by the sodCI virulence gene.
J.Mol.Biol., 302, 2000
8W18
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BU of 8w18 by Molmil
The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms
Descriptor: Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain, Plasma protease C1 inhibitor
Authors:Garrigues, R.J, Garcia, B.L.
Deposit date:2024-02-15
Release date:2024-06-26
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation.
J Immunol., 213, 2024
8XGT
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BU of 8xgt by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGY
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BU of 8xgy by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-16
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
5KSY
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BU of 5ksy by Molmil
hMiro1 C-domain GDP Complex P41212 Crystal Form
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Mitochondrial Rho GTPase 1
Authors:Klosowiak, J.L, Focia, P.J, Rice, S.E, Freymann, D.M.
Deposit date:2016-07-10
Release date:2016-09-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.482 Å)
Cite:Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Sci Rep, 6, 2016
1MAV
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BU of 1mav by Molmil
CRYSTAL STRUCTURE OF THE RESPONSE REGULATOR DIVK AT PH 6.0 IN COMPLEX WITH MN2+
Descriptor: MANGANESE (II) ION, cell division response regulator DivK
Authors:Guillet, V, Ohta, N, Cabantous, S, Newton, A, Samama, J.-P, Structural Proteomics in Europe (SPINE)
Deposit date:2002-08-02
Release date:2002-12-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic and Biochemical Studies of DivK Reveal Novel Features of an Essential Response Regulator in Caulobacter crescentus.
J.Biol.Chem., 277, 2002
3GTU
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BU of 3gtu by Molmil
LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Patskovsky, Y.V, Patskovska, L.N, Listowsky, I.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.
Biochemistry, 38, 1999
2ZA4
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BU of 2za4 by Molmil
Crystal Structural Analysis of Barnase-barstar Complex
Descriptor: Barstar, CHLORIDE ION, Ribonuclease
Authors:Urakubo, Y, Ikura, T, Ito, N.
Deposit date:2007-10-01
Release date:2008-05-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structural analysis of protein-protein interactions drastically destabilized by a single mutation
Protein Sci., 17, 2008
5NHZ
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BU of 5nhz by Molmil
VIM-2_10b. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding
Descriptor: Beta-lactamase class B VIM-2, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Skagseth, S, Akhter, S, Paulsen, M.H, Samuelsen, O, Muhammad, Z, Leiros, K.-K.S, Bayer, A.
Deposit date:2017-03-22
Release date:2017-04-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Metallo-beta-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.
Eur J Med Chem, 135, 2017
2ZH7
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BU of 2zh7 by Molmil
Complex structure of AFCCA with tRNAminiDG
Descriptor: CCA-adding enzyme, SULFATE ION, tRNA (33-MER)
Authors:Toh, Y, Tomita, K.
Deposit date:2008-02-01
Release date:2008-08-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme
Embo J., 27, 2008
1ML5
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BU of 1ml5 by Molmil
Structure of the E. coli ribosomal termination complex with release factor 2
Descriptor: 30S 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Klaholz, B.P, Pape, T, Zavialov, A.V, Myasnikov, A.G, Orlova, E.V, Vestergaard, B, Ehrenberg, M, van Heel, M.
Deposit date:2002-08-30
Release date:2003-01-14
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Structure of the Escherichia coli ribosomal termination complex with release factor 2
Nature, 421, 2003
6NSO
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BU of 6nso by Molmil
An Unexpected Intermediate in the Reaction Catalyzed by Quinolinate Synthase
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, IRON/SULFUR CLUSTER, Quinolinate synthase A
Authors:Esakova, O.A, Grove, T.L, Silakov, A, Yennawar, N.H, Booker, S.J.
Deposit date:2019-01-25
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase.
J.Am.Chem.Soc., 141, 2019
5KSZ
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BU of 5ksz by Molmil
hMiro EF hand and cGTPase domains in the GMPPCP-bound state
Descriptor: CHLORIDE ION, MAGNESIUM ION, Mitochondrial Rho GTPase 1, ...
Authors:Klosowiak, J.L, Focia, P.J, Rice, S.E, Freymann, D.M.
Deposit date:2016-07-10
Release date:2016-09-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Sci Rep, 6, 2016
5KTY
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BU of 5kty by Molmil
hMiro EF hand and cGTPase domains, GDP and Ca2+ bound state
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Klosowiak, J.L, Focia, P.J, Rice, S.E, Freymann, D.M.
Deposit date:2016-07-12
Release date:2016-09-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Sci Rep, 6, 2016
1NG8
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BU of 1ng8 by Molmil
G15-Gramicidin A in Sodium Dodecyl Sulfate Micelles (NMR)
Descriptor: GRAMICIDIN A
Authors:Sham, S.S, Townsley, L.E, Hinton, J.F.
Deposit date:2002-12-17
Release date:2002-12-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:The Structure, Cation Binding, Transport and Conductance of Gly15-Gramicidin a Incorporated Into Sds Micelles and Pc/Pg Vesicles
Biochemistry, 42, 2003

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数据于2024-09-18公开中

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