3ZJZ
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![BU of 3zjz by Molmil](/molmil-images/mine/3zjz) | Open-form NavMS Sodium Channel Pore (with C-terminal Domain) | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, ION TRANSPORT PROTEIN, ... | Authors: | Bagneris, C, Naylor, C.E, Wallace, B.A. | Deposit date: | 2013-01-21 | Release date: | 2013-10-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Role of the C-Terminal Domain in the Structure and Function of Tetrameric Sodium Channels. Nat.Commun., 4, 2013
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1A1R
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![BU of 1a1r by Molmil](/molmil-images/mine/1a1r) | HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX | Descriptor: | NS3 PROTEIN, NS4A PROTEIN, ZINC ION | Authors: | Kim, J.L, Morgenstern, K.A, Lin, C, Fox, T, Dwyer, M.D, Landro, J.A, Chambers, S.P, Markland, W, Lepre, C.A, O'Malley, E.T, Harbeson, S.L, Rice, C.M, Murcko, M.A, Caron, P.R, Thomson, J.A. | Deposit date: | 1997-12-15 | Release date: | 1998-06-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell(Cambridge,Mass.), 87, 1996
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1JO1
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![BU of 1jo1 by Molmil](/molmil-images/mine/1jo1) | N7-Guanine Adduct of 2,7-diaminomitosene with DNA | Descriptor: | 5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE | Authors: | Subramaniam, G, Paz, M.M, Kumar, G.S, Das, A, Palom, Y, Clement, C.C, Patel, D.J, Tomasz, M. | Deposit date: | 2001-07-26 | Release date: | 2001-09-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry, 40, 2001
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1AH7
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![BU of 1ah7 by Molmil](/molmil-images/mine/1ah7) | PHOSPHOLIPASE C FROM BACILLUS CEREUS | Descriptor: | PHOSPHOLIPASE C, ZINC ION | Authors: | Greaves, R. | Deposit date: | 1997-04-14 | Release date: | 1997-12-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature, 338, 1989
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2OR2
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![BU of 2or2 by Molmil](/molmil-images/mine/2or2) | Structure of the W47A/W242A Mutant of Bacterial Phosphatidylinositol-Specific Phospholipase C | Descriptor: | 1-phosphatidylinositol phosphodiesterase | Authors: | Shao, C, Shi, X, Wehbi, H, Zambonelli, C, Head, J.F, Seaton, B.A, Roberts, M.F. | Deposit date: | 2007-02-01 | Release date: | 2007-02-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase C. J.Biol.Chem., 282, 2007
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4OOW
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![BU of 4oow by Molmil](/molmil-images/mine/4oow) | HCV NS5B polymerase with a fragment of quercetagetin | Descriptor: | CATECHOL, RNA-directed RNA polymerase | Authors: | Guichou, J.F, Ahmed-Belkacem, A, Rozenn, B, Nazim, N, Hernandez, E, Pallier, C, Pawlotsky, J.M. | Deposit date: | 2014-02-04 | Release date: | 2014-12-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res., 42, 2014
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3EL7
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![BU of 3el7 by Molmil](/molmil-images/mine/3el7) | Crystal structure of c-Src in complex with pyrazolopyrimidine 3 | Descriptor: | 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src | Authors: | Dar, A.C, Lopez, M.S, Shokat, K.M. | Deposit date: | 2008-09-20 | Release date: | 2008-10-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem.Biol., 15, 2008
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3Q3Z
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![BU of 3q3z by Molmil](/molmil-images/mine/3q3z) | Structure of a c-di-GMP-II riboswitch from C. acetobutylicum bound to c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, c-di-GMP-II riboswitch | Authors: | Smith, K.D, Shanahan, C.A, Moore, E.L, Simon, A.C, Strobel, S.A. | Deposit date: | 2010-12-22 | Release date: | 2011-05-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proc.Natl.Acad.Sci.USA, 108, 2011
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1EGI
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![BU of 1egi by Molmil](/molmil-images/mine/1egi) | STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION DOMAIN (CRD-4) FROM THE MACROPHAGE MANNOSE RECEPTOR | Descriptor: | CALCIUM ION, MACROPHAGE MANNOSE RECEPTOR | Authors: | Feinberg, H, Park-Snyder, S, Kolatkar, A.R, Heise, C.T, Taylor, M.E, Weis, W.I. | Deposit date: | 2000-02-15 | Release date: | 2000-08-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J.Biol.Chem., 275, 2000
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2GGM
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![BU of 2ggm by Molmil](/molmil-images/mine/2ggm) | Human centrin 2 xeroderma pigmentosum group C protein complex | Descriptor: | CALCIUM ION, Centrin-2, DNA-repair protein complementing XP-C cells | Authors: | Thompson, J.R. | Deposit date: | 2006-03-24 | Release date: | 2006-04-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. J.Biol.Chem., 281, 2006
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2G15
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![BU of 2g15 by Molmil](/molmil-images/mine/2g15) | Structural Characterization of autoinhibited c-Met kinase | Descriptor: | activated met oncogene | Authors: | Wang, W, Marimuthu, A, Tsai, J, Kumar, A, Krupka, H.I, Zhang, C, Powell, B, Suzuki, Y, Nguyen, H, Tabrizizad, M, Luu, C, West, B.L. | Deposit date: | 2006-02-13 | Release date: | 2006-03-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2G01
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![BU of 2g01 by Molmil](/molmil-images/mine/2g01) | Pyrazoloquinolones as Novel, Selective JNK1 inhibitors | Descriptor: | 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE, C-jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, ... | Authors: | Abad-Zapatero, C. | Deposit date: | 2006-02-10 | Release date: | 2006-04-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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2MA3
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![BU of 2ma3 by Molmil](/molmil-images/mine/2ma3) | NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Methanothermobacter thermautotrophicus | Descriptor: | DNA replication initiator (Cdc21/Cdc54) | Authors: | Wiedemann, C, Ohlenschlager, O, Medagli, B, Onesti, S, Gorlach, M. | Deposit date: | 2013-06-26 | Release date: | 2014-12-31 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex. Nucleic Acids Res., 43, 2015
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3QYY
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![BU of 3qyy by Molmil](/molmil-images/mine/3qyy) | A Novel Interaction Mode between a Microbial GGDEF Domain and the Bis-(3, 5 )-cyclic di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Yang, C.-Y, Chin, K.-H, Chou, S.-H. | Deposit date: | 2011-03-04 | Release date: | 2011-11-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)(2) at the active site Acta Crystallogr.,Sect.D, 67, 2011
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1A93
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![BU of 1a93 by Molmil](/molmil-images/mine/1a93) | NMR SOLUTION STRUCTURE OF THE C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | MAX PROTEIN, MYC PROTO-ONCOGENE PROTEIN | Authors: | Lavigne, P, Crump, M.P, Gagne, S.M, Hodges, R.S, Kay, C.M, Sykes, B.D. | Deposit date: | 1998-04-15 | Release date: | 1998-10-21 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. J.Mol.Biol., 281, 1998
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2J50
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![BU of 2j50 by Molmil](/molmil-images/mine/2j50) | Structure of Aurora-2 in complex with PHA-739358 | Descriptor: | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6, SULFATE ION | Authors: | Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P. | Deposit date: | 2006-09-08 | Release date: | 2006-11-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | 1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile. J.Med.Chem., 49, 2006
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2ZFZ
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![BU of 2zfz by Molmil](/molmil-images/mine/2zfz) | Crystal structure of the C-terminal domain hexamer of ArgR from Mycobacterium tuberculosis in complex with arginine | Descriptor: | ARGININE, Arginine repressor, GUANIDINE | Authors: | Cherney, L.T, Cherney, M.M, Garen, C.R, Lu, G.J, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2008-01-16 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 64, 2008
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2DQ5
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![BU of 2dq5 by Molmil](/molmil-images/mine/2dq5) | solution structure of the Mid1 B Box2 Chc(D/C)C2H2 Zinc-Binding Domain: insights into an evolutionary conserved ring fold | Descriptor: | Midline-1, ZINC ION | Authors: | Massiah, M.A, Matts, J.A.B, Short, K.M, Simmons, B.N, Singireddy, S, Zou, J, Cox, T.C. | Deposit date: | 2006-05-20 | Release date: | 2007-04-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of the MID1 B-box2 CHC(D/C)C(2)H(2) Zinc-binding Domain: Insights into an Evolutionarily Conserved RING Fold J.Mol.Biol., 369, 2007
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3EBN
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![BU of 3ebn by Molmil](/molmil-images/mine/3ebn) | A Special Dimerization of SARS-CoV Main Protease C-Terminal Domain Due to Domain-swapping | Descriptor: | Replicase polyprotein 1ab | Authors: | Zhong, N, Zhang, S, Xue, F, Kang, X, Lou, Z, Xia, B. | Deposit date: | 2008-08-28 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer PROTEIN SCI., 18, 2009
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3EA1
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![BU of 3ea1 by Molmil](/molmil-images/mine/3ea1) | Crystal Structure of the Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | Descriptor: | 1-phosphatidylinositol phosphodiesterase, ZINC ION | Authors: | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | Deposit date: | 2008-08-24 | Release date: | 2009-04-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface. J.Biol.Chem., 284, 2009
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2TN4
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![BU of 2tn4 by Molmil](/molmil-images/mine/2tn4) | FOUR CALCIUM TNC | Descriptor: | CALCIUM ION, TROPONIN C | Authors: | Love, M.L, Dominguez, R, Houdusse, A, Cohen, C. | Deposit date: | 1997-09-18 | Release date: | 1998-04-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. Structure, 5, 1997
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3VKE
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![BU of 3vke by Molmil](/molmil-images/mine/3vke) | |
1TN4
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![BU of 1tn4 by Molmil](/molmil-images/mine/1tn4) | FOUR CALCIUM TNC | Descriptor: | CALCIUM ION, TROPONIN C | Authors: | Love, M.L, Dominguez, R, Houdusse, A, Cohen, C. | Deposit date: | 1997-09-18 | Release date: | 1998-04-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily. Structure, 5, 1997
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2SRC
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![BU of 2src by Molmil](/molmil-images/mine/2src) | CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC | Authors: | Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C. | Deposit date: | 1998-12-29 | Release date: | 1999-07-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol.Cell, 3, 1999
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365D
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![BU of 365d by Molmil](/molmil-images/mine/365d) | STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*GP*(CBR)P*CP*TP*GP*G)-3'), IMIDAZOLE-PYRROLE POLYAMIDE | Authors: | Kielkopf, C.L, Baird, E.E, Dervan, P.B, Rees, D.C. | Deposit date: | 1997-12-17 | Release date: | 1998-02-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for G.C recognition in the DNA minor groove. Nat.Struct.Biol., 5, 1998
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