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8XHK
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BU of 8xhk by Molmil
Crystal structure of alpha-Oxoamine Synthase Alb29 with PLP cofactor
Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, PYRIDOXAL-5'-PHOSPHATE
Authors:Xu, M.J, Zhang, D.K.
Deposit date:2023-12-18
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Int.J.Biol.Macromol., 268, 2024
8XHD
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BU of 8xhd by Molmil
Crystal structure of alpha-Oxoamine Synthase Alb29 with PLP cofactor and L-glutamate
Descriptor: 8-amino-7-oxononanoate synthase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE
Authors:Xu, M.J, Zhang, D.K.
Deposit date:2023-12-17
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Int.J.Biol.Macromol., 268, 2024
8XHA
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BU of 8xha by Molmil
Crystal structure of alpha-Oxoamine Synthase Alb29 with PLP cofactor and L-glutamate
Descriptor: 8-amino-7-oxononanoate synthase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid, PYRIDOXAL-5'-PHOSPHATE
Authors:Xu, M.J, Zhang, D.K.
Deposit date:2023-12-17
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Int.J.Biol.Macromol., 268, 2024
8XH7
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BU of 8xh7 by Molmil
Structure of EBV LMP1 oligomer
Descriptor: Latent membrane protein 1
Authors:Gao, P, Huang, J.F.
Deposit date:2023-12-17
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Assembly and activation of EBV latent membrane protein 1
To Be Published
8XH6
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BU of 8xh6 by Molmil
Structure of EBV LMP1 dimer
Descriptor: Latent membrane protein 1
Authors:Gao, P, Huang, J.F.
Deposit date:2023-12-17
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Assembly and activation of EBV latent membrane protein 1
To Be Published
8XGY
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BU of 8xgy by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-16
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGW
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BU of 8xgw by Molmil
Solution structure of d(CGATCG)2-Baicalein complex
Descriptor: 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, DNA (5'-D(*CP*AP*CP*GP*TP*G)-3')
Authors:Nair, M.S, Kumar, S.
Deposit date:2023-12-15
Release date:2024-02-07
Last modified:2024-06-26
Method:SOLUTION NMR
Cite:Solution structure of d(CACGTG)2-Baicalein complex.
To Be Published
8XGV
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BU of 8xgv by Molmil
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction (PPI) Inhibitors
Descriptor: (2~{R},3~{S})-3-[[(2~{S})-2-[4-[(3-ethoxypyridin-2-yl)methyl]phenyl]-2-fluoranyl-ethanoyl]amino]-2-methyl-3-(4-methylphenyl)propanoic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ...
Authors:Otake, K, Hara, Y, Ubukata, M, Inoue, M, Nagahashi, N, Motoda, D, Ogawa, N, Hantani, Y, Hantani, R, Adachi, T, Nomura, A, Yamaguchi, K, Maekawa, M, Mamada, H, Motomura, T, Sato, M, Harada, K.
Deposit date:2023-12-15
Release date:2024-05-22
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
J.Med.Chem., 67, 2024
8XGT
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BU of 8xgt by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGR
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BU of 8xgr by Molmil
ETB-eGt complex bound to endothelin-1
Descriptor: Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ...
Authors:Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O.
Deposit date:2023-12-15
Release date:2024-04-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application.
Biochem.Biophys.Res.Commun., 693, 2024
8XGK
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BU of 8xgk by Molmil
Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Ihhibitors
Descriptor: (2~{R},3~{S})-3-[[(2~{S})-2-(4-chlorophenyl)-2-fluoranyl-ethanoyl]amino]-3-[3-(2-cyano-2-methyl-propoxy)-4-methyl-phenyl]-2-methyl-propanoic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ...
Authors:Otake, K, Hara, Y, Ubukata, M, Inoue, M, Nagahashi, N, Motoda, D, Ogawa, N, Hantani, Y, Hantani, R, Adachi, T, Nomura, A, Yamaguchi, K, Maekawa, M, Mamada, H, Motomura, T, Sato, M, Harada, K.
Deposit date:2023-12-15
Release date:2024-05-22
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
J.Med.Chem., 67, 2024
8XGC
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BU of 8xgc by Molmil
Structure of yeast replisome associated with FACT and histone hexamer, Composite map
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ...
Authors:Li, N, Gao, Y, Yu, D, Gao, N, Zhai, Y.
Deposit date:2023-12-15
Release date:2024-02-14
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Parental histone transfer caught at the replication fork.
Nature, 627, 2024
8XGB
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BU of 8xgb by Molmil
Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
Descriptor: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XGA
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BU of 8xga by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((tetrahydro-2H-pyran-4-yl)oxy)indolin-2-one
Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-(oxan-4-yloxy)-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-15
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (3.537 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XFY
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BU of 8xfy by Molmil
The Crystal Structure of RSK2 from Biortus.
Descriptor: 2,6-bis(fluoranyl)-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol, Ribosomal protein S6 kinase alpha-3
Authors:Wang, F, Cheng, W, Lv, Z, Lin, D, Pan, W.
Deposit date:2023-12-14
Release date:2024-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Crystal Structure of RSK2 from Biortus.
To Be Published
8XFV
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BU of 8xfv by Molmil
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-(piperidin-4-yloxy)indolin-2-one
Descriptor: 3-(1~{H}-benzimidazol-5-ylmethylidene)-4-piperidin-4-yloxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION
Authors:Li, G.-B, Wang, X.-Y.
Deposit date:2023-12-14
Release date:2024-06-12
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
J.Med.Chem., 67, 2024
8XFR
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BU of 8xfr by Molmil
Structure of the alginate epimerase/lyase complexed with tetra-mannuronic acid
Descriptor: ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Fujiwara, T.
Deposit date:2023-12-14
Release date:2024-05-15
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum.
Febs Lett., 598, 2024
8XFQ
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BU of 8xfq by Molmil
Structure of the alginate epimerase/lyase complexed with penta-mannuronic acid
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL, ...
Authors:Fujiwara, T.
Deposit date:2023-12-14
Release date:2024-05-15
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum.
Febs Lett., 598, 2024
8XFM
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BU of 8xfm by Molmil
The Crystal Structure of MNK2 from Biortus.
Descriptor: 1,2-ETHANEDIOL, 5-(3-azanyl-1~{H}-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one, MAP kinase-interacting serine/threonine-protein kinase 2, ...
Authors:Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J.
Deposit date:2023-12-14
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structure of MNK2 from Biortus.
To Be Published
8XFL
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BU of 8xfl by Molmil
The Crystal Structure of MARK4 from Biortus.
Descriptor: MAP/microtubule affinity-regulating kinase 4
Authors:Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J.
Deposit date:2023-12-14
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Crystal Structure of MARK4 from Biortus.
To Be Published
8XFD
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BU of 8xfd by Molmil
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, Isoform L-type of Pyruvate kinase PKLR, MAGNESIUM ION, ...
Authors:Sun, R, Achour, A.
Deposit date:2023-12-13
Release date:2024-05-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348
Crystals, 2024
8XF3
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BU of 8xf3 by Molmil
Crystal structure of the reassembled C-phycocyanin octamer from Thermoleptolyngbya sp. O-77
Descriptor: C-phycocyanin alpha chain, C-phycocyanin beta chain, PHOSPHATE ION, ...
Authors:Nguyen, H.K, Teramoto, T, Kakuta, Y, Yoon, K.S.
Deposit date:2023-12-13
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin.
J.Biosci.Bioeng., 137, 2024
8XF2
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BU of 8xf2 by Molmil
Crystal structure of the reassembled C-phycocyanin hexamer from Thermoleptolyngbya sp. O-77
Descriptor: C-phycocyanin alpha chain, C-phycocyanin beta chain, PHOSPHATE ION, ...
Authors:Nguyen, H.K, Teramoto, T, Kakuta, Y, Yoon, K.S.
Deposit date:2023-12-13
Release date:2024-05-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin.
J.Biosci.Bioeng., 137, 2024
8XF1
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BU of 8xf1 by Molmil
Crystal structure of the dissociated C-phycocyanin beta-chain from Thermoleptolyngbya sp. O-77
Descriptor: C-phycocyanin beta chain, PHYCOCYANOBILIN
Authors:Nguyen, H.K, Teramoto, T, Kakuta, Y, Yoon, K.S.
Deposit date:2023-12-13
Release date:2024-05-22
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin.
J.Biosci.Bioeng., 137, 2024
8XF0
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BU of 8xf0 by Molmil
Crystal structure of the dissociated C-phycocyanin alpha-chain from Thermoleptolyngbya sp. O-77
Descriptor: C-phycocyanin alpha chain, MAGNESIUM ION, PHYCOCYANOBILIN
Authors:Nguyen, H.K, Teramoto, T, Kakuta, Y, Yoon, K.S.
Deposit date:2023-12-13
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Disassembly and reassembly of the non-conventional thermophilic C-phycocyanin.
J.Biosci.Bioeng., 137, 2024

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数据于2024-06-26公开中

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