PDB: 8861 resultsInfo pagesStatus searchChemie searchBIRD

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3QHW	Structure of a pCDK2/CyclinA transition-state mimic Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ... Authors: Young, M.A, Jacobsen, D.M, Bao, Z.Q. Deposit date: 2011-01-26 Release date: 2011-05-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
1S9K	Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site Descriptor: Human IL-2 ARRE1 Promoter Element, Minus Strand, Plus Strand, ... Authors: Wang, D, Stroud, J.C, Chen, L. Deposit date: 2004-02-04 Release date: 2005-06-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site To be Published
3QQK	CDK2 in complex with inhibitor L4 Descriptor: 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](phenyl)methanone Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-02-15 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RPV	CDK2 in complex with inhibitor RC-2-88 Descriptor: 1,2-ETHANEDIOL, 4-{[4-amino-5-(3-aminobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-27 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3R7V	CDK2 in complex with inhibitor KVR-1-9 Descriptor: 1,2-ETHANEDIOL, 5-nitro-2-[(pyridin-2-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-23 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R71	CDK2 in complex with inhibitor KVR-1-162 Descriptor: 1,2-ETHANEDIOL, 4-[(3-methoxypropyl)amino]-5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-22 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R83	CDK2 in complex with inhibitor KVR-2-92 Descriptor: 1,2-ETHANEDIOL, 4-(4-aminopiperidin-1-yl)-2-{[(2-aminopyrimidin-5-yl)methyl]amino}-5-nitrobenzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-23 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R9D	CDK2 in complex with inhibitor RC-2-135 Descriptor: 4-amino-N-(3-fluorophenyl)-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-25 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RNI	CDK2 in complex with inhibitor RC-3-86 Descriptor: 3-[(4-amino-5-benzoyl-1,3-thiazol-2-yl)amino]benzenesulfonamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-22 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RM7	CDK2 in complex with inhibitor KVR-1-91 Descriptor: 1,2-ETHANEDIOL, 2-[(4-hydroxybenzyl)amino]-5-nitrobenzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-20 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3RAL	CDK2 in complex with inhibitor RC-2-34 Descriptor: 4-{[4-amino-5-(3-methoxybenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-28 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3R1S	CDK2 in complex with inhibitor KVR-1-127 Descriptor: 1,2-ETHANEDIOL, 2-{[(6-chloropyridin-3-yl)methyl]amino}-5-nitrobenzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-11 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3RAH	CDK2 in complex with inhibitor RC-2-22 Descriptor: Cyclin-dependent kinase 2, [4-amino-2-(cyclohexylamino)-1,3-thiazol-5-yl](naphthalen-2-yl)methanone Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-28 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3Q3B	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors Descriptor: 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one, Glycogen synthase kinase-3 beta Authors: Pandit, J. Deposit date: 2010-12-21 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors Bioorg.Med.Chem.Lett., 21, 2011
3QQF	CDK2 in complex with inhibitor L1 Descriptor: 1,2-ETHANEDIOL, 5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-02-15 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3RPG	Bmi1/Ring1b-UbcH5c complex structure Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... Authors: Bentley, M.L, Dong, K.C, Cochran, A.G. Deposit date: 2011-04-26 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6485 Å) Cite: Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. Embo J., 30, 2011
3RKQ	NKX2.5 Homeodomain dimer bound to ANF-242 DNA Descriptor: ANF-242 DNA, Homeobox protein Nkx-2.5, MAGNESIUM ION Authors: Genis, C, Scone, P, Kasahara, H, Nam, H.-J. Deposit date: 2011-04-18 Release date: 2012-05-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51, 2012
3R1Q	CDK2 in complex with inhibitor KVR-1-102 Descriptor: 1,2-ETHANEDIOL, 4-chloro-2-{[(6-chloropyridin-3-yl)methyl]amino}-5-nitrobenzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-11 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R73	CDK2 in complex with inhibitor KVR-1-164 Descriptor: 1,2-ETHANEDIOL, 4-[(3-aminopropyl)amino]-5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-22 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R8V	CDK2 in complex with inhibitor RC-1-135 Descriptor: Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](3-nitrophenyl)methanone Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-24 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RJC	CDK2 in complex with inhibitor L4-12 Descriptor: Cyclin-dependent kinase 2, {4-amino-2-[(3-fluorophenyl)amino]-1,3-thiazol-5-yl}(phenyl)methanone Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-15 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3R28	CDK2 in complex with inhibitor KVR-1-140 Descriptor: 1,2-ETHANEDIOL, 4-chloro-5-nitro-2-[(3,4,5-trifluorobenzyl)amino]benzamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3R7I	CDK2 in complex with inhibitor KVR-1-74 Descriptor: 1,2-ETHANEDIOL, 4-{[(2-carbamoyl-4-nitrophenyl)amino]methyl}benzoic acid, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-03-22 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3RPR	CDK2 in complex with inhibitor RC-2-49 Descriptor: Cyclin-dependent kinase 2, [4-amino-2-(phenylamino)-1,3-thiazol-5-yl][3-(trifluoromethyl)phenyl]methanone Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-27 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3RPY	CDK2 in complex with inhibitor RC-2-40 Descriptor: 4-amino-2-[(4-sulfamoylphenyl)amino]-1,3-thiazole-5-carboxamide, Cyclin-dependent kinase 2 Authors: Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. Deposit date: 2011-04-27 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013

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