4WWI
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6KRV
| Crystal structure of mouse IgG2b Fc complexed with B domain of Protein A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-2B chain C region, ... | Authors: | Taniguchi, Y, Satoh, T, Yagi, H, Kato, K. | Deposit date: | 2019-08-22 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q. Int J Mol Sci, 21, 2019
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6FGO
| Fc in complex with engineered calcium binding domain Z | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Venskutonyte, R, Kanje, S, Hober, S, Lindkvist-Petersson, K. | Deposit date: | 2018-01-11 | Release date: | 2018-06-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies. J. Mol. Biol., 430, 2018
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4HJG
| Meditope-enabled trastuzumab | Descriptor: | Immunoglobulin G-binding protein A, Protein L fragment, Trastuzumab heavy chain, ... | Authors: | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | Deposit date: | 2012-10-12 | Release date: | 2013-10-09 | Last modified: | 2013-11-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HKZ
| Trastuzumab Fab complexed with Protein L and Protein A fragments | Descriptor: | CHLORIDE ION, Immunoglobulin G-binding protein A, Protein L fragment, ... | Authors: | Avery, K.N, Zer, C, Bzymek, K.P, Williams, J.C. | Deposit date: | 2012-10-15 | Release date: | 2013-10-09 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110, 2013
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4IOI
| Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC | Descriptor: | Immunoglobulin G-binding protein A, Protein L, Trastuzumab heavy chain, ... | Authors: | Bzymek, K.P, Zer, C, Avery, K.N, Williams, J.C. | Deposit date: | 2013-01-07 | Release date: | 2013-10-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 110, 2013
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5COC
| Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus | Descriptor: | CALCIUM ION, Immunoglobulin G-binding protein A,Calmodulin | Authors: | Jeong, W.H, Lee, H, Song, D.H, Lee, J.O. | Deposit date: | 2015-07-20 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6691 Å) | Cite: | Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker. Nat Commun, 7, 2016
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6BAH
| Trastuzumab Fab v3 with 5-diphenyl meditope variant | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain,IGH@ protein, ... | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | Deposit date: | 2017-10-12 | Release date: | 2018-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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6BAE
| Trastuzumab Fab v3 in complex with CQFDLSTRRLKC | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain, ... | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | Deposit date: | 2017-10-12 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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6B9Z
| Trastuzumab Fab v3 | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain, ... | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | Deposit date: | 2017-10-11 | Release date: | 2018-09-05 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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6B9Y
| Trastuzumab Fab v3 in complex with 5-phenyl meditope variant | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain, ... | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | Deposit date: | 2017-10-11 | Release date: | 2018-09-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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4ZNC
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5U5F
| MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK | Descriptor: | 5-DIPHENYL LONG MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, ... | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | Deposit date: | 2016-12-06 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Meditope Enabled Trastuzumab I83E Variant In Complex With (Ac)Cqfda(Ph)2Strrlrcggsk To Be Published
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5U6A
| CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-PEG3-MEDITOPE | Descriptor: | Heavy Chain, Immunoglobulin G binding protein A, Light Chain, ... | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | Deposit date: | 2016-12-07 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.736 Å) | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-PEG3-Meditope To Be Published
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5U4Y
| IgG Fc bound to 3 helix of the B-domain from Protein A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 fc, Immunoglobulin G-binding protein A, ... | Authors: | Ultsch, M.H, Eigenbrot, C. | Deposit date: | 2016-12-06 | Release date: | 2017-05-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4994 Å) | Cite: | 3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix. Protein Eng. Des. Sel., 30, 2017
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5U5M
| CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE | Descriptor: | AZIDO-PEG4-MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB, ... | Authors: | Williams, J.C, Bzymek, K.P, Pucket, J, Avery, K.A, Ma, Y, Xie, J, Zer, C, Horne, D. | Deposit date: | 2016-12-06 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal Structure Of I83E Meditope-Enabled Trastuzumab With Azido-Meditope To Be Published
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5U3D
| STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT | Descriptor: | Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, MEMAB TRASTUZUMAB FAB LIGHT CHAIN I83E, ... | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | Deposit date: | 2016-12-01 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Meditope Enabled Trastuzumab I83E Variant To Be Published
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1FC2
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5H75
| Crystal structure of the MrsD-Protein A fusion protein | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Mersacidin decarboxylase,Immunoglobulin G-binding protein A | Authors: | Youn, S.J, Kwon, N.Y, Lee, J.H, Kim, J.H, Lee, H, Lee, J.O. | Deposit date: | 2016-11-17 | Release date: | 2017-06-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.738 Å) | Cite: | Construction of novel repeat proteins with rigid and predictable structures using a shared helix method. Sci Rep, 7, 2017
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3MZW
| HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin G-binding protein A, ... | Authors: | Eigenbrot, C, Ultsch, M.H. | Deposit date: | 2010-05-13 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for high-affinity HER2 receptor binding by an engineered protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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5XBY
| Crystal structure of the PKA-Protein A fusion protein (end-to-end fusion) | Descriptor: | cAMP-dependent protein kinase type II-alpha regulatory subunit,Immunoglobulin G-binding protein A | Authors: | Youn, S.J, Kwon, N.Y, Lee, J.H, Kim, J.H, Lee, H, Lee, J.O. | Deposit date: | 2017-03-21 | Release date: | 2017-07-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Construction of novel repeat proteins with rigid and predictable structures using a shared helix method. Sci Rep, 7, 2017
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7RXD
| CryoEM structure of RBD domain of COVID-19 in complex with Legobody | Descriptor: | Fab_8D3_2 heavy chain, Fab_8D3_2 light chain, Maltodextrin-binding protein,Immunoglobulin G-binding protein A,Immunoglobulin G-binding protein G, ... | Authors: | Wu, X.D, Rapoport, T.A. | Deposit date: | 2021-08-22 | Release date: | 2021-10-06 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc.Natl.Acad.Sci.USA, 118, 2021
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7RXC
| CryoEM structure of KDELR with Legobody | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ER lumen protein-retaining receptor 2, Fab_8D3_2 heavy chain, ... | Authors: | Wu, X.D, Rapoport, T.A. | Deposit date: | 2021-08-22 | Release date: | 2021-10-06 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc.Natl.Acad.Sci.USA, 118, 2021
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8JXS
| Structure of nanobody-bound DRD1_PF-6142 complex | Descriptor: | 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine, D(1A) dopamine receptor, Fab 8D3 heavy chain, ... | Authors: | Zhuang, Y, Xu, Y, Fan, L, Wang, S, Xu, H.E. | Deposit date: | 2023-07-01 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of psychedelic LSD recognition at dopamine D 1 receptor. Neuron, 2024
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8JXR
| Structure of nanobody-bound DRD1_LSD complex | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, D(1A) dopamine receptor, Fab 8D3 heavy chain, ... | Authors: | Zhuang, Y, Xu, Y, Fan, L, Wang, S, Xu, H.E. | Deposit date: | 2023-07-01 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structural basis of psychedelic LSD recognition at dopamine D 1 receptor. Neuron, 2024
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