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2QS3
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BU of 2qs3 by Molmil
Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution
Descriptor: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-5-phenylthiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ...
Authors:Alushin, G.M, Jane, D.E, Mayer, M.L.
Deposit date:2007-07-30
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Neuropharmacology, 56, 2009
2QS2
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BU of 2qs2 by Molmil
Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms resolution
Descriptor: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-bromo-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)thiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ...
Authors:Alushin, G.M, Jane, D.E, Mayer, M.L.
Deposit date:2007-07-30
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
Neuropharmacology, 60, 2011
2RCA
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BU of 2rca by Molmil
Crystal structure of the NR3B ligand binding core complex with glycine at 1.58 Angstrom resolution
Descriptor: GLYCEROL, GLYCINE, Glutamate [NMDA] receptor subunit 3B
Authors:Yao, Y, Mayer, M.L.
Deposit date:2007-09-19
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Embo J., 27, 2008
4YU0
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BU of 4yu0 by Molmil
Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLUTAMIC ACID, Glutamate receptor 2,Glutamate receptor 2, ...
Authors:Chebli, M, Salazar, H, Baranovic, J, Carbone, A.L, Ghisi, V, Faelber, K, Lau, A.Y, Daumke, O, Plested, A.J.R.
Deposit date:2015-03-18
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of the tetrameric GluA2 ligand-binding domain in complex with glutamate at 1.26 Angstroms resolution
To Be Published
2RCB
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Crystal structure of the NR3B ligand binding core complex with D-serine at 1.62 Angstrom resolution
Descriptor: D-SERINE, GLYCEROL, Glutamate [NMDA] receptor subunit 3B
Authors:Yao, Y, Mayer, M.L.
Deposit date:2007-09-19
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Embo J., 27, 2008
6YK4
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BU of 6yk4 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A
Descriptor: (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.999 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6SBT
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BU of 6sbt by Molmil
Structure of GluK1 ligand-binding domain (S1S2) in complex with N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl benzamide at 2.3 A resolution
Descriptor: CHLORIDE ION, GLYCEROL, Glutamate receptor ionotropic, ...
Authors:Moellerud, S, Frydenvang, K, Kastrup, J.S.
Deposit date:2019-07-22
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology.
Acs Chem Neurosci, 10, 2019
6YK3
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BU of 6yk3 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.20A
Descriptor: (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione, AMMONIUM ION, CHLORIDE ION, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6YK2
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BU of 6yk2 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin- 2,4(1H,3H)-dione at resolution 1.60A
Descriptor: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.612 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6YK5
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BU of 6yk5 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A
Descriptor: (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
6YK6
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BU of 6yk6 by Molmil
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A
Descriptor: (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione, CHLORIDE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2020-04-05
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.469 Å)
Cite:Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
Acs Chem Neurosci, 11, 2020
2I3V
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BU of 2i3v by Molmil
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
Authors:Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E.
Deposit date:2006-08-21
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
Cell(Cambridge,Mass.), 127, 2006
4YMB
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BU of 4ymb by Molmil
Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111
Descriptor: (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Moller, C, Tapken, D, Kastrup, J.S, Frydenvang, K.
Deposit date:2015-03-06
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.
J.Med.Chem., 58, 2015
2I0C
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BU of 2i0c by Molmil
Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006
2I0B
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BU of 2i0b by Molmil
Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2, ...
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006
4Z0I
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BU of 4z0i by Molmil
Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLUTAMIC ACID, Glutamate receptor 2,Glutamate receptor 2, ...
Authors:Baranovic, J, Chebli, M, Salazar, H, Carbone, A.L, Ghisi, V, Faelber, K, Lau, A.Y, Daumke, O, Plested, A.J.R.
Deposit date:2015-03-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of the tetrameric wt GluA2 ligand-binding domain bound to glutamate at 1.45 Angstroms resolution
To Be Published
4ZDM
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BU of 4zdm by Molmil
Pleurobrachia bachei iGluR3 LBD Glycine Complex
Descriptor: GLYCINE, Glutamate receptor kainate-like protein, SODIUM ION, ...
Authors:Grey, R.J, Mayer, M.L.
Deposit date:2015-04-17
Release date:2015-10-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.
Proc.Natl.Acad.Sci.USA, 112, 2015
6U5S
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BU of 6u5s by Molmil
NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Nakagawa, T.
Deposit date:2019-08-28
Release date:2019-12-04
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Science, 366, 2019
4YMA
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BU of 4yma by Molmil
Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109
Descriptor: (3R)-3-(3-carboxy-5-hydroxyphenyl)-L-proline, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Moller, C, Tapken, D, Kastrup, J.S, Frydenvang, K.
Deposit date:2015-03-06
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.
J.Med.Chem., 58, 2015
6UCB
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BU of 6ucb by Molmil
GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Glutamate receptor 2, ...
Authors:Nakagawa, T.
Deposit date:2019-09-15
Release date:2019-12-04
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Science, 366, 2019
6UD8
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BU of 6ud8 by Molmil
GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Glutamate receptor 2, ...
Authors:Nakagawa, T.
Deposit date:2019-09-18
Release date:2019-12-04
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Science, 366, 2019
2I3W
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BU of 2i3w by Molmil
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant
Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID
Authors:Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E.
Deposit date:2006-08-21
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
Cell(Cambridge,Mass.), 127, 2006
2GFE
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BU of 2gfe by Molmil
Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
Authors:Mayer, M.L.
Deposit date:2006-03-21
Release date:2006-08-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.
J.Neurosci., 26, 2006
5FXI
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BU of 5fxi by Molmil
GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation
Descriptor: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B
Authors:Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H.
Deposit date:2016-03-02
Release date:2016-05-11
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
7YSV
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BU of 7ysv by Molmil
GluK1-1a extracellular domain captured in SYM2081 bound desensitized state
Descriptor: Glutamate receptor
Authors:Dhingra, S, Kumar, J.
Deposit date:2022-08-13
Release date:2023-08-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (8.01 Å)
Cite:Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors
Elife, 2023

221051

数据于2024-06-12公开中

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