2GHL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ghl by Molmil](/molmil-images/mine/2ghl) | Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743 | Descriptor: | 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14 | Authors: | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Brugel, T.A. | Deposit date: | 2006-03-27 | Release date: | 2006-04-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg.Med.Chem.Lett., 16, 2006
|
|
2G2K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2g2k by Molmil](/molmil-images/mine/2g2k) | NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5) | Descriptor: | Eukaryotic translation initiation factor 5 | Authors: | Conte, M.R, Kelly, G, Babon, J, Sanfelice, D, Smerdon, S.J, Proud, C.G. | Deposit date: | 2006-02-16 | Release date: | 2006-06-13 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors Biochemistry, 45, 2006
|
|
2GCG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2gcg by Molmil](/molmil-images/mine/2gcg) | Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase | Descriptor: | (2R)-2,3-DIHYDROXYPROPANOIC ACID, Glyoxylate reductase/hydroxypyruvate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Booth, M.P.S, Conners, R, Rumsby, G, Brady, R.L. | Deposit date: | 2006-03-14 | Release date: | 2006-07-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase J.Mol.Biol., 360, 2006
|
|
6EZ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ez4 by Molmil](/molmil-images/mine/6ez4) | NMR structure of the C-terminal domain of the human RPAP3 protein | Descriptor: | RNA polymerase II-associated protein 3 | Authors: | Fabre, P, Chagot, M.E, Bragantini, B, Manival, X, Quinternet, M. | Deposit date: | 2017-11-14 | Release date: | 2018-04-18 | Last modified: | 2024-01-17 | Method: | SOLUTION NMR | Cite: | The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones. Nat Commun, 9, 2018
|
|
2GHM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ghm by Molmil](/molmil-images/mine/2ghm) | Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449 | Descriptor: | 3-(2-CHLOROBENZYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14 | Authors: | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Maier, J.A. | Deposit date: | 2006-03-27 | Release date: | 2006-05-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg.Med.Chem.Lett., 16, 2006
|
|
2GO5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2go5 by Molmil](/molmil-images/mine/2go5) | Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex | Descriptor: | SRP RNA, Signal recognition particle 19 kDa protein (SRP19), Signal recognition particle 54 kDa protein (SRP54), ... | Authors: | Halic, M, Gartmann, M, Schlenker, O, Mielke, T, Pool, M.R, Sinning, I, Beckmann, R. | Deposit date: | 2006-04-12 | Release date: | 2006-06-13 | Last modified: | 2011-07-13 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Signal Recognition Particle Receptor Exposes the Ribosomal Translocon Binding Site Science, 312, 2006
|
|
2GS3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2gs3 by Molmil](/molmil-images/mine/2gs3) | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4) | Descriptor: | CHLORIDE ION, Phospholipid hydroperoxide glutathione peroxidase | Authors: | Johansson, C, Kavanagh, K.L, Rojkova, A, Gileadi, O, von Delft, F, Arrowsmith, C, Weigelt, J, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2006-04-25 | Release date: | 2006-05-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4) To be Published
|
|
2GK9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2gk9 by Molmil](/molmil-images/mine/2gk9) | Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma | Descriptor: | phosphatidylinositol-4-phosphate 5-kinase, type II, gamma | Authors: | Uppenberg, J, Hogbom, M, Ogg, D, Arrowsmith, C, Berglund, H, Collins, R, Ehn, M, Flodin, S, Flores, A, Graslund, S, Holmberg-Schiavone, L, Edwards, A, Hammarstrom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Hallberg, B.M, Structural Genomics Consortium (SGC) | Deposit date: | 2006-03-31 | Release date: | 2006-05-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma To be Published
|
|
1RY8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ry8 by Molmil](/molmil-images/mine/1ry8) | Prostaglandin F synthase complexed with NADPH and rutin | Descriptor: | Aldo-keto reductase family 1 member C3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RUTIN | Authors: | Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. | Deposit date: | 2003-12-19 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal structure of human prostaglandin F synthase (AKR1C3). Biochemistry, 43, 2004
|
|
1RY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ry0 by Molmil](/molmil-images/mine/1ry0) | Structure of prostaglandin F synthase with prostaglandin D2 | Descriptor: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROSTAGLANDIN D2 | Authors: | Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F. | Deposit date: | 2003-12-19 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal structure of human prostaglandin F synthase (AKR1C3). Biochemistry, 43, 2004
|
|
4YVP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yvp by Molmil](/molmil-images/mine/4yvp) | Crystal Structure of AKR1C1 complexed with glibenclamide | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhao, Y, Zheng, X, Zhang, H, Hu, X. | Deposit date: | 2015-03-20 | Release date: | 2015-11-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240, 2015
|
|
1BHS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bhs by Molmil](/molmil-images/mine/1bhs) | HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE | Descriptor: | 17BETA-HYDROXYSTEROID DEHYDROGENASE | Authors: | Ghosh, D. | Deposit date: | 1995-04-19 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution. Structure, 3, 1995
|
|
4GDL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gdl by Molmil](/molmil-images/mine/4gdl) | Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 | Descriptor: | Autophagy protein 5, Autophagy-related protein 16-1, SODIUM ION, ... | Authors: | Otomo, C, Metlagel, Z, Takaesu, G, Otomo, T. | Deposit date: | 2012-07-31 | Release date: | 2012-12-05 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.875 Å) | Cite: | Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat.Struct.Mol.Biol., 20, 2013
|
|
2R55
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r55 by Molmil](/molmil-images/mine/2r55) | Human StAR-related lipid transfer protein 5 | Descriptor: | StAR-related lipid transfer protein 5 | Authors: | Lehtio, L, Busam, R.D, Arrowsmith, C.H, Berglund, H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Herman, M.D, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Sagemark, J, Sundstrom, M, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Persson, C, Structural Genomics Consortium (SGC) | Deposit date: | 2007-09-03 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Comparative structural analysis of lipid binding START domains. Plos One, 6, 2011
|
|
4G1C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g1c by Molmil](/molmil-images/mine/4g1c) | Human SIRT5 bound to Succ-IDH2 and Carba-NAD | Descriptor: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... | Authors: | Dai, H. | Deposit date: | 2012-07-10 | Release date: | 2012-08-15 | Last modified: | 2012-09-19 | Method: | X-RAY DIFFRACTION (1.944 Å) | Cite: | Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. J.Org.Chem., 77, 2012
|
|
4GK0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gk0 by Molmil](/molmil-images/mine/4gk0) | Crystal structure of human Rev3-Rev7-Rev1 complex | Descriptor: | DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B | Authors: | Tao, J, Min, X, Wei, X. | Deposit date: | 2012-08-10 | Release date: | 2013-03-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
|
|
4G2L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g2l by Molmil](/molmil-images/mine/4g2l) | Human PDE9 in complex with selective compound | Descriptor: | 1-cyclopentyl-6-{(1R)-1-[3-(pyrimidin-2-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Liu, S. | Deposit date: | 2012-07-12 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem., 55, 2012
|
|
4G2J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g2j by Molmil](/molmil-images/mine/4g2j) | Human pde9 in complex with selective compound | Descriptor: | 1-cyclopentyl-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Liu, S. | Deposit date: | 2012-07-12 | Release date: | 2013-05-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem., 55, 2012
|
|
4GH6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gh6 by Molmil](/molmil-images/mine/4gh6) | Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28 | Descriptor: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, N-(4-methoxyphenyl)-N~2~-[1-(2-methylphenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-L-alaninamide, ... | Authors: | Hou, J, Ke, H. | Deposit date: | 2012-08-07 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design. J.Med.Chem., 55, 2012
|
|
2RQP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2rqp by Molmil](/molmil-images/mine/2rqp) | |
4GK5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gk5 by Molmil](/molmil-images/mine/4gk5) | Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex | Descriptor: | DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... | Authors: | Tao, J, Min, X, Wei, X. | Deposit date: | 2012-08-10 | Release date: | 2013-03-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
|
|
4GDK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gdk by Molmil](/molmil-images/mine/4gdk) | Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 | Descriptor: | Autophagy protein 5, Autophagy-related protein 16-1, SODIUM ION, ... | Authors: | Otomo, C, Metlagel, Z, Takaesu, G, Otomo, T. | Deposit date: | 2012-07-31 | Release date: | 2012-12-05 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat.Struct.Mol.Biol., 20, 2013
|
|
4QFV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qfv by Molmil](/molmil-images/mine/4qfv) | |
4PVV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pvv by Molmil](/molmil-images/mine/4pvv) | Micobacterial Adenosine Kinase in complex with inhibitor | Descriptor: | 5-ethynyl-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Adenosine kinase | Authors: | Pichova, I, Hocek, M, Dostal, J, Rezacova, P. | Deposit date: | 2014-03-18 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides J.Med.Chem., 57, 2014
|
|
4GML
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gml by Molmil](/molmil-images/mine/4gml) | |