4PVV

Micobacterial Adenosine Kinase in complex with inhibitor

Summary for 4PVV

• Entry DOI: 10.2210/pdb4pvv/pdb
• Related: 4O1L
• Descriptor: Adenosine kinase, 5-ethynyl-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: adenosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 34794.23

Authors

Pichova, I.,Hocek, M.,Dostal, J.,Rezacova, P. (deposition date: 2014-03-18, release date: 2014-11-26, Last modification date: 2024-03-20)

• Primary citation: Snasel, J.,Naus, P.,Dostal, J.,Hnizda, A.,Fanfrlik, J.,Brynda, J.,Bourderioux, A.,Dusek, M.,Dvorakova, H.,Stolarikova, J.,Zabranska, H.,Pohl, R.,Konecny, P.,Dzubak, P.,Votruba, I.,Hajduch, M.,Rezacova, P.,Veverka, V.,Hocek, M.,Pichova, I.; Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides; J.Med.Chem., 57:8268-8279, 2014; PubMed: 25259627; DOI: 10.1021/jm500497v

Experimental method

X-RAY DIFFRACTION (2.5 Å)