8JL9
| Cryo-EM structure of the human nucleosome with scFv | Descriptor: | DNA (193-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. | Deposit date: | 2023-06-02 | Release date: | 2023-10-04 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
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8JLD
| Cryo-EM structure of the 145 bp human nucleosome containing acetylated H3 tail | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. | Deposit date: | 2023-06-02 | Release date: | 2023-10-04 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
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8JLA
| Cryo-EM structure of the human nucleosome lacking N-terminal region of H2A, H2B, H3, and H4 | Descriptor: | DNA (193-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. | Deposit date: | 2023-06-02 | Release date: | 2023-10-04 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
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6TED
| Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 | Descriptor: | DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... | Authors: | Vos, S.M, Farnung, L, Cramer, P. | Deposit date: | 2019-11-11 | Release date: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat.Struct.Mol.Biol., 27, 2020
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7ZSB
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7ZSA
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7ZS9
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8K5P
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8W8E
| human co-transcriptional RNA capping enzyme RNGTT | Descriptor: | DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | Deposit date: | 2023-09-02 | Release date: | 2024-04-10 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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6GMH
| Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | Descriptor: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | Authors: | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | Deposit date: | 2018-05-26 | Release date: | 2018-08-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature, 560, 2018
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4WQS
| Thermus thermophilus RNA polymerase backtracked complex | Descriptor: | DNA (28-MER), DNA (5'-D(P*GP*TP*AP*GP*CP*TP*TP*GP*TP*GP*GP*TP*AP*GP*TP*GP*AP*CP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Murayama, Y, Sekine, S, Yokoyama, S. | Deposit date: | 2014-10-22 | Release date: | 2015-02-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.306 Å) | Cite: | The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions. Mol.Cell, 57, 2015
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8W8F
| human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | Deposit date: | 2023-09-02 | Release date: | 2024-04-10 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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6GML
| Structure of paused transcription complex Pol II-DSIF-NELF | Descriptor: | DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | Authors: | Vos, S.M, Farnung, L, Urlaub, H, Cramer, P. | Deposit date: | 2018-05-27 | Release date: | 2018-09-05 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of paused transcription complex Pol II-DSIF-NELF. Nature, 560, 2018
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5NSS
| Cryo-EM structure of RNA polymerase-sigma54 holoenzyme with promoter DNA and transcription activator PspF intermedate complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta', ... | Authors: | Glyde, R, Ye, F.Z, Darbari, V.C, Zhang, N, Buck, M, Zhang, X.D. | Deposit date: | 2017-04-26 | Release date: | 2017-06-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation. Mol. Cell, 67, 2017
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5U5Q
| 12 Subunit RNA Polymerase II at Room Temperature collected using SFX | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Bushnell, D.A, Oberthur, D, Mariani, V, Yefanov, O, Tolstikova, A, Barty, A. | Deposit date: | 2016-12-07 | Release date: | 2017-03-29 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Double-flow focused liquid injector for efficient serial femtosecond crystallography. Sci Rep, 7, 2017
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3I4N
| 8-oxoguanine containing RNA polymerase II elongation complex E | Descriptor: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Damsma, G.E, Cramer, P. | Deposit date: | 2009-07-02 | Release date: | 2009-09-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Molecular basis of transcriptional mutagenesis at 8-oxoguanine J.Biol.Chem., 284, 2009
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3I4M
| 8-oxoguanine containing RNA polymerase II elongation complex D | Descriptor: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Damsma, G.E, Cramer, P. | Deposit date: | 2009-07-02 | Release date: | 2009-09-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Molecular basis of transcriptional mutagenesis at 8-oxoguanine J.Biol.Chem., 284, 2009
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4WZQ
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7EU0
| The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | Descriptor: | DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | Deposit date: | 2021-05-15 | Release date: | 2021-12-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
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7EU1
| The cryo-EM structure of A. thaliana Pol IV-RDR2 holoenzyme | Descriptor: | DNA-directed RNA polymerase IV subunit 1, DNA-directed RNA polymerases II and IV subunit 5A, DNA-directed RNA polymerases II, ... | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | Deposit date: | 2021-05-15 | Release date: | 2021-12-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
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6KF3
| Cryo-EM structure of Thermococcus kodakarensis RNA polymerase | Descriptor: | DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit A'', DNA-directed RNA polymerase subunit D, ... | Authors: | Jun, S.-H, Hyun, J, Jeong, H, Cha, J.S, Kim, H, Bartlett, M.S, Cho, H.-S, Murakami, K.S. | Deposit date: | 2019-07-06 | Release date: | 2020-07-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase. Nat Commun, 11, 2020
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6N58
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation II | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | Deposit date: | 2018-11-21 | Release date: | 2020-02-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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6NPW
| SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide | Descriptor: | PHOSPHATE ION, Ser2/Ser5 phosphorylated peptide, Ssu72 ortholog, ... | Authors: | Irani, S, Zhang, Y. | Deposit date: | 2019-01-18 | Release date: | 2019-04-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.486 Å) | Cite: | Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription. J.Biol.Chem., 294, 2019
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4YGX
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6N57
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | Deposit date: | 2018-11-21 | Release date: | 2020-02-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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