6BRB
 
 | | Novel non-antibody protein scaffold targeting CD40L | | Descriptor: | CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. | | Deposit date: | 2017-11-30 | | Release date: | 2018-12-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019
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4QHU
 | | Crystal Structure of IL-17A/Fab6785 complex | | Descriptor: | CHLORIDE ION, Fab6785 heavy chain, Fab6785 light chain, ... | | Authors: | Luo, J, Gilliland, G.L, Malia, T, Obmolova, G, Teplyakov, A. | | Deposit date: | 2014-05-29 | | Release date: | 2015-08-05 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation
To be Published
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7EAK
 | | Echovirus3 full particle in complex with 5G3 fab | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Feng, R. | | Deposit date: | 2021-03-07 | | Release date: | 2021-07-14 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
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7EAH
 | | Echovirus3 empty expanded particle | | Descriptor: | Capsid protein VP0, Capsid protein VP1, Capsid protein VP3 | | Authors: | Feng, R. | | Deposit date: | 2021-03-07 | | Release date: | 2021-07-14 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
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7EAI
 | | Echovirus3 empty compacted particle | | Descriptor: | Capsid protein VP0, Capsid protein VP1, Capsid protein VP3, ... | | Authors: | Feng, R. | | Deposit date: | 2021-03-07 | | Release date: | 2021-07-14 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
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7EAJ
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1BGX
 | | TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB | | Descriptor: | TAQ DNA POLYMERASE, TP7 MAB | | Authors: | Murali, R, Sharkey, D.J, Daiss, J.L, Krishna Murthy, H.M. | | Deposit date: | 1998-06-02 | | Release date: | 1998-10-14 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme.
Proc.Natl.Acad.Sci.USA, 95, 1998
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3LS5
 | | Anti-tetrahydrocannabinol Fab Fragment, Free Form | | Descriptor: | Heavy chain of antibody Fab fragment, Light chain of antibody Fab fragment | | Authors: | Niemi, M.H, Rouvinen, J. | | Deposit date: | 2010-02-12 | | Release date: | 2010-06-02 | | Last modified: | 2014-01-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A structural insight into the molecular recognition of a (-)-Delta9-tetrahydrocannabinol and the development of a sensitive, one-step, homogeneous immunocomplex-based assay for its detection
J.Mol.Biol., 400, 2010
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1A7L
 | | DOMINANT B-CELL EPITOPE FROM THE PRES2 REGION OF HEPATITIS B VIRUS IN THE FORM OF AN INSERTED PEPTIDE SEGMENT IN MALTODEXTRIN-BINDING PROTEIN | | Descriptor: | MALE-B363, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Saul, F.A, Vulliez-Lenormand, B, Lema, F, Bentley, G.A. | | Deposit date: | 1998-03-16 | | Release date: | 1998-06-17 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of a dominant B-cell epitope from the preS2 region of hepatitis B virus in the form of an inserted peptide segment in maltodextrin-binding protein.
J.Mol.Biol., 280, 1998
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2Y36
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5OCA
 | | PCSK9:Fab Complex with Dextran Sulfate | | Descriptor: | 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ... | | Authors: | Thirup, S.S, Vilstrup, J.P. | | Deposit date: | 2017-06-30 | | Release date: | 2017-09-20 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nat Commun, 8, 2017
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3VE0
 | | Crystal structure of Sudan Ebolavirus Glycoprotein (strain Boniface) bound to 16F6 | | Descriptor: | 16F6 Antibody chain A, 16F6 Antibody chain B, Envelope glycoprotein, ... | | Authors: | Saphire, E.O, Bale, S, Dias, J.M. | | Deposit date: | 2012-01-06 | | Release date: | 2012-04-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.353 Å) | | Cite: | Structural basis for differential neutralization of ebolaviruses.
Viruses, 4, 2012
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2C1P
 | | Fab-fragment of enantioselective antibody complexed with finrozole | | Descriptor: | 4-[(1S,2R)-3-(4-FLUOROPHENYL)-2-HYDROXY-1-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]BENZONITRILE, IGH-4 PROTEIN, IGK-C PROTEIN | | Authors: | Parkkinen, T, Nevanen, T.K, Koivula, A, Rouvinen, J. | | Deposit date: | 2005-09-19 | | Release date: | 2006-01-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of an Enantioselective Fab-Fragment in Free and Complex Forms.
J.Mol.Biol., 357, 2006
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7XQ8
 | | Structure of human B-cell antigen receptor of the IgM isotype | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2022-05-07 | | Release date: | 2022-08-17 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of the human IgM B cell receptor.
Science, 377, 2022
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1YYL
 | | crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD4M33, scorpion-toxin mimic of CD4, ... | | Authors: | Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D. | | Deposit date: | 2005-02-25 | | Release date: | 2005-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
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8CDE
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4YWG
 | | Crystal structure of 830A in complex with V1V2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of anti-HIV-1 gp120 V1V2 antibody 830A, Light chain of anti-HIV-1 gp120 V1V2 antibody 830A, ... | | Authors: | Pan, R, Kong, X. | | Deposit date: | 2015-03-20 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.998 Å) | | Cite: | The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel.
J.Virol., 89, 2015
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3UO1
 | | Structure of a monoclonal antibody complexed with its MHC-I antigen | | Descriptor: | ANTI-MHC-I MONOCLONAL ANTIBODY, 64-3-7 H CHAIN, 64-3-7 L CHAIN, ... | | Authors: | Margulies, D.H, Mage, M.G, Wang, R, Natarajan, K. | | Deposit date: | 2011-11-16 | | Release date: | 2012-07-25 | | Last modified: | 2012-08-01 | | Method: | X-RAY DIFFRACTION (1.641 Å) | | Cite: | The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.
J.Immunol., 189, 2012
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2VIU
 | | INFLUENZA VIRUS HEMAGGLUTININ | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Bizebard, T, Fleury, D, Gigant, B, Wharton, S.A, Skehel, J.J, Knossow, M. | | Deposit date: | 1997-12-22 | | Release date: | 1998-04-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Antigen distortion allows influenza virus to escape neutralization.
Nat.Struct.Biol., 5, 1998
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1YYM
 | | crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120), ... | | Authors: | Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D. | | Deposit date: | 2005-02-25 | | Release date: | 2005-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
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7T8W
 | | Structure of antibody 3G12 bound to Respiratory Syncytial Virus G central conserved domain mutant S177Q | | Descriptor: | 3G12 Fab Heavy chain, 3G12 Fab Light chain, Mature secreted glycoprotein G | | Authors: | Nunez Castrejon, A.M, O'Rourke, S.M, Kauvar, L.M, DuBois, R.M. | | Deposit date: | 2021-12-17 | | Release date: | 2022-02-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens.
J.Virol., 96, 2022
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3O0R
 | | Crystal structure of nitric oxide reductase from Pseudomonas aeruginosa in complex with antibody fragment | | Descriptor: | CALCIUM ION, FE (III) ION, HEME C, ... | | Authors: | Hino, T, Matsumoto, Y, Nagano, S, Sugimoto, H, Fukumori, Y, Murata, T, Iwata, S, Shiro, Y. | | Deposit date: | 2010-07-20 | | Release date: | 2010-12-29 | | Last modified: | 2013-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of biological N2O generation by bacterial nitric oxide reductase
Science, 330, 2010
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4U6G
 | | Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide | | Descriptor: | 10E8 Fab Heavy Chain, 10E8 Fab Light Chain, SAH-MPER(662-683KKK)(B,q) | | Authors: | Ofek, G, Bird, G.H, Walensky, L.D, Kwong, P.D. | | Deposit date: | 2014-07-28 | | Release date: | 2014-12-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (4.2012 Å) | | Cite: | Structural Fidelity and Neutralizing Antibody Binding Capacity of
Hydrocarbon-Stapled HIV-1 Antigens
To be published
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4CC8
 | | Pre-fusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy | | Descriptor: | GP120, GP41, MONOCLONAL ANTIBODY VRC03 FAB HEAVY CHAIN, ... | | Authors: | Bartesaghi, A, Merk, A, Borgnia, M.J, Milne, J.L.S, Subramaniam, S. | | Deposit date: | 2013-10-18 | | Release date: | 2013-10-30 | | Last modified: | 2018-01-10 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Prefusion Structure of Trimeric HIV-1 Envelope Glycoprotein Determined by Cryo-Electron Microscopy.
Nat.Struct.Mol.Biol., 20, 2013
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1DVF
 | | IDIOTOPIC ANTIBODY D1.3 FV FRAGMENT-ANTIIDIOTOPIC ANTIBODY E5.2 FV FRAGMENT COMPLEX | | Descriptor: | FV D1.3, FV E5.2, ZINC ION | | Authors: | Braden, B.C, Fields, B.A, Ysern, X, Dall'Acqua, W, Goldbaum, F.A, Poljak, R.J, Mariuzza, R.A. | | Deposit date: | 1996-04-13 | | Release date: | 1996-08-17 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of an Fv-Fv idiotope-anti-idiotope complex at 1.9 A resolution.
J.Mol.Biol., 264, 1996
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