7T5Q
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![BU of 7t5q by Molmil](/molmil-images/mine/7t5q) | Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Rebowski, G, van Eeuwen, T, Boczkowska, M, Dominguez, R. | Deposit date: | 2021-12-13 | Release date: | 2023-06-14 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of an Arp2/3 complex mini-branch capped by capping protein (CapZ) To Be Published
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7QHO
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![BU of 7qho by Molmil](/molmil-images/mine/7qho) | Cytochrome bcc-aa3 supercomplex (respiratory supercomplex III2/IV2) from Corynebacterium glutamicum (as isolated) | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Kao, W.-C, Hunte, C. | Deposit date: | 2021-12-13 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for safe and efficient energy conversion in a respiratory supercomplex Nature Communications, 13, 2022
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7QHM
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![BU of 7qhm by Molmil](/molmil-images/mine/7qhm) | Cytochrome bcc-aa3 supercomplex (respiratory supercomplex III2/IV2) from Corynebacterium glutamicum (stigmatellin and azide bound) | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, AZIDE ION, ... | Authors: | Kao, W.-C, Hunte, C. | Deposit date: | 2021-12-13 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for safe and efficient energy conversion in a respiratory supercomplex. Nat Commun, 13, 2022
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7QHR
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![BU of 7qhr by Molmil](/molmil-images/mine/7qhr) | |
7QHL
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![BU of 7qhl by Molmil](/molmil-images/mine/7qhl) | Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24 | Descriptor: | 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ... | Authors: | Djukic, S, Skerlova, J, Rezacova, P. | Deposit date: | 2021-12-13 | Release date: | 2022-07-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J.Med.Chem., 65, 2022
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7QHH
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![BU of 7qhh by Molmil](/molmil-images/mine/7qhh) | Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... | Authors: | Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. | Deposit date: | 2021-12-12 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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7WA0
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![BU of 7wa0 by Molmil](/molmil-images/mine/7wa0) | Crystal structure of Bovine Pancreatic Trypsin in complex with Benzamidine at Room Temperature | Descriptor: | BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | Authors: | Sakai, N, Okumura, H, Yamamoto, M, Kumasaka, T. | Deposit date: | 2021-12-11 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | In situ crystal data-collection and ligand-screening system at SPring-8. Acta Crystallogr.,Sect.F, 78, 2022
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7WA2
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![BU of 7wa2 by Molmil](/molmil-images/mine/7wa2) | Crystal structure of Bovine Pancreatic Trypsin in complex with 4-Methoxybenzamidine at Room Temperature | Descriptor: | 4-methoxybenzenecarboximidamide, CALCIUM ION, Cationic trypsin, ... | Authors: | Sakai, N, Okumura, H, Yamamoto, M, Kumasaka, T. | Deposit date: | 2021-12-11 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | In situ crystal data-collection and ligand-screening system at SPring-8. Acta Crystallogr.,Sect.F, 78, 2022
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7T56
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![BU of 7t56 by Molmil](/molmil-images/mine/7t56) | |
7T54
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![BU of 7t54 by Molmil](/molmil-images/mine/7t54) | |
7T57
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![BU of 7t57 by Molmil](/molmil-images/mine/7t57) | |
7T55
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![BU of 7t55 by Molmil](/molmil-images/mine/7t55) | |
7QHB
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![BU of 7qhb by Molmil](/molmil-images/mine/7qhb) | Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... | Authors: | Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. | Deposit date: | 2021-12-11 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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7T4X
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![BU of 7t4x by Molmil](/molmil-images/mine/7t4x) | |
7T4K
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![BU of 7t4k by Molmil](/molmil-images/mine/7t4k) | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4N
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![BU of 7t4n by Molmil](/molmil-images/mine/7t4n) | Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4L
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![BU of 7t4l by Molmil](/molmil-images/mine/7t4l) | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4M
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![BU of 7t4m by Molmil](/molmil-images/mine/7t4m) | Structure of dodecameric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4R
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![BU of 7t4r by Molmil](/molmil-images/mine/7t4r) | CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ... | Authors: | Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C. | Deposit date: | 2021-12-10 | Release date: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for HCMV Pentamer receptor recognition and antibody neutralization. Sci Adv, 8, 2022
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7T4V
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![BU of 7t4v by Molmil](/molmil-images/mine/7t4v) | Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4W
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![BU of 7t4w by Molmil](/molmil-images/mine/7t4w) | Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | (2R)-2-({(2S,3S)-1-[(1H-benzimidazol-2-yl)methyl]-2-phenylpiperidin-3-yl}oxy)-2-(3,5-dichlorophenyl)ethan-1-ol, CHLORIDE ION, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4T
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![BU of 7t4t by Molmil](/molmil-images/mine/7t4t) | Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T4U
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![BU of 7t4u by Molmil](/molmil-images/mine/7t4u) | Crystal Structure of cGMP-dependent Protein Kinase | Descriptor: | 3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic acid, cGMP-dependent protein kinase 1 | Authors: | Zebisch, M, Silvestre, L, Fischmann, T.O. | Deposit date: | 2021-12-10 | Release date: | 2023-06-14 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Selective small molecule activation of PKG1alpha: structure and function Commun Biol, 2023
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7T3X
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![BU of 7t3x by Molmil](/molmil-images/mine/7t3x) | Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | Descriptor: | Serine/threonine-protein kinase PINK1 | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-09 | Release date: | 2021-12-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.53 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T47
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![BU of 7t47 by Molmil](/molmil-images/mine/7t47) | KRAS G12D (GppCp) with MRTX-1133 | Descriptor: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, ACETATE ION, GLYCEROL, ... | Authors: | Thomas, N.C, Gunn, R.J, Lawson, J.D, Wang, X, Matthew, M.A. | Deposit date: | 2021-12-09 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | A Non-covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of KRAS-dependent Signaling and Regression of KRASG12D-mutant Tumors Nature, 2022
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