8ZQH
 
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8ZUC
 | | The Crystal structure of mol080 bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | | Descriptor: | 3C-like proteinase, 6-[[6-chloranyl-2-(3-methylbutyl)indazol-5-yl]amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]pyrimidine-2,4-dione | | Authors: | Yan, M, Zhang, H. | | Deposit date: | 2024-06-08 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CL pro ) inhibitors with anti-coronavirus activities.
Bioorg.Chem., 154, 2025
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8ZDI
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8ZDO
 | | Cryo-EM structure of Mycobacteriophage Douge baseplate (gp13, gp17, gp23, gp16, gp18 and gp20) | | Descriptor: | Baseplate hub protein (gp18), Baseplate upper protein (gp23), Central fiber protein (gp20), ... | | Authors: | Maharana, J, Wang, C.H, Tsai, L.A, Lowary, T.L, Ho, M.C. | | Deposit date: | 2024-05-02 | | Release date: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Mycobacteriophage cryo-EM studies reveal the siphophage architecture at the amino acid level and its host interaction for viral genome ejection
To Be Published
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5JR3
 | | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone | | Descriptor: | 7-hydroxy-4-methyl-2H-chromen-2-one, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Wang, F, Johnson, B.R, Huber, T.D, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2016-05-05 | | Release date: | 2016-06-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published)
To Be Published
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8ZYR
 | | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A3 | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Gao, W, Zheng, J, Zhu, Y, Huang, Z. | | Deposit date: | 2024-06-18 | | Release date: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A3
To Be Published
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2HZ4
 | | Abl kinase domain unligated and in complex with tetrahydrostaurosporine | | Descriptor: | 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Proto-oncogene tyrosine-protein kinase ABL1 | | Authors: | Cowan-Jacob, S.W, Fendrich, G, Liebetanz, J, Fabbro, D, Manley, P. | | Deposit date: | 2006-08-08 | | Release date: | 2007-01-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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5K1I
 | | PDE4 crystal structure in complex with small molecule inhibitor | | Descriptor: | 4-[(5-acetyl-2-ethyl-3-oxo-6-phenyl-2,3-dihydropyridazin-4-yl)amino]benzoic acid, MAGNESIUM ION, ZINC ION, ... | | Authors: | Segarra, V, Hernandez, B, Ferrer-Miralles, N, Korndoerfer, I, Aymami, J. | | Deposit date: | 2016-05-18 | | Release date: | 2016-12-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
J. Med. Chem., 59, 2016
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8ZDL
 | | Cryo-EM structure of Mycobacteriophage Douge genome-free connector (gp5, gp9, gp10, gp12 and gp13) | | Descriptor: | Adaptor Protein (gp9), Protal Protein (gp5), Stopper Protein (gp10), ... | | Authors: | Maharana, J, Wang, C.H, Tsai, L.A, Lowary, T.L, Ho, M.C. | | Deposit date: | 2024-05-02 | | Release date: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Mycobacteriophage cryo-EM studies reveal the siphophage architecture at the amino acid level and its host interaction for viral genome ejection
To Be Published
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5K38
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2HYR
 | | Crystal structure of a complex of griffithsin with maltose | | Descriptor: | 1,2-ETHANEDIOL, Griffithsin, MAGNESIUM ION, ... | | Authors: | Ziolkowska, N.E, Wlodawer, A. | | Deposit date: | 2006-08-07 | | Release date: | 2007-04-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins, 67, 2007
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5JRQ
 | | BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM | | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide, ... | | Authors: | Grasso, M.J, Marmorstein, R. | | Deposit date: | 2016-05-06 | | Release date: | 2016-09-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.287 Å) | | Cite: | Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
Acs Chem.Biol., 11, 2016
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8ZU0
 | | CryoEM structure of a tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG | | Authors: | Jiang, W.X, Cheng, X.Q, Dong, X, Ma, L.X, Xing, Q. | | Deposit date: | 2024-06-07 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | CryoEM structure of a tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
To Be Published
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8ZVT
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1KO2
 | | VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with an oxidized Cys (cysteinesulfonic) | | Descriptor: | ACETATE ION, VIM-2 metallo-beta-lactamase, ZINC ION | | Authors: | Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O. | | Deposit date: | 2001-12-20 | | Release date: | 2003-09-02 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form
J.Mol.Biol., 375, 2008
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8ZVM
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8ZRL
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1KP8
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8ZUI
 | | Binary cluster of TNF-TNFR1 ectodomain complex | | Descriptor: | Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, membrane form | | Authors: | Lim, C.S, Lee, J.O. | | Deposit date: | 2024-06-09 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Highly ordered clustering of TNF alpha and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane.
Nat Commun, 16, 2025
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5K55
 | | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with fructose-6-phosphate | | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | | Deposit date: | 2016-05-23 | | Release date: | 2017-06-07 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.977 Å) | | Cite: | Structural studies of human muscle FBPase
To Be Published
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8ZEJ
 | | Structure of E.coli ribosome in complex with an engineered arrest peptide | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Sriramoju, M.K, Ko, T.P, Draczkowski, P, Hsu, S.T.D. | | Deposit date: | 2024-05-06 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Structure of E.coli ribosome in complex with an engineered arrest peptide
To Be Published
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8ZR0
 | | Crystal structure of Skd3 in complex with AMPPNP | | Descriptor: | Caseinolytic peptidase B protein homolog, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Lee, S, Lee, C. | | Deposit date: | 2024-06-03 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of Skd3 in complex with AMPPNP
To Be Published
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8ZT9
 | | The Crystal structure of mol066 bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 | | Descriptor: | 3C-like proteinase, 6-[(6-chloranyl-2-propan-2-yl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]pyrimidine-2,4-dione, GLYCEROL | | Authors: | Yan, M, Zhang, H. | | Deposit date: | 2024-06-06 | | Release date: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CL pro ) inhibitors with anti-coronavirus activities.
Bioorg.Chem., 154, 2025
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8ZVR
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8ZVU
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