7EV4
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![BU of 7ev4 by Molmil](/molmil-images/mine/7ev4) | Crystal structure of the Lon-like protease MtaLonC with S582A mutation in complex with F-b20-Q | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | Deposit date: | 2021-05-20 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7EV6
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![BU of 7ev6 by Molmil](/molmil-images/mine/7ev6) | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with F-b20-Q | Descriptor: | Endopeptidase La, F-b20-Q peptide {ortho-aminobenzoic acid (Abz)- QLRSLNGEWRFAWFPAPEAV[Tyr(3-NO2)]A}, PHOSPHATE ION | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | Deposit date: | 2021-05-20 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7EUY
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![BU of 7euy by Molmil](/molmil-images/mine/7euy) | Crystal structure of the Lon-like protease MtaLonC with D582A mutation in complex with substrate polypeptide | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | Deposit date: | 2021-05-19 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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7EUX
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![BU of 7eux by Molmil](/molmil-images/mine/7eux) | Crystal structure of the Lon-like protease MtaLonC with D581A mutation in complex with substrate polypeptide | Descriptor: | ALA-PRO-GLU-ALA-VAL, Endopeptidase La, PHOSPHATE ION | Authors: | Hsieh, K.Y, Kuo, C.I, Su, S.C, Huang, K.F, Chang, C.I. | Deposit date: | 2021-05-19 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
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6ON2
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![BU of 6on2 by Molmil](/molmil-images/mine/6on2) | Lon Protease from Yersinia pestis with Y2853 substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ... | Authors: | Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | Deposit date: | 2019-04-19 | Release date: | 2019-05-01 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
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7SXO
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![BU of 7sxo by Molmil](/molmil-images/mine/7sxo) | Yeast Lon (PIM1) with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | Deposit date: | 2021-11-24 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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6V11
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![BU of 6v11 by Molmil](/molmil-images/mine/6v11) | Lon Protease from Yersinia pestis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | Deposit date: | 2019-11-19 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
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3K1J
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![BU of 3k1j by Molmil](/molmil-images/mine/3k1j) | Crystal structure of Lon protease from Thermococcus onnurineus NA1 | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Cha, S.S, An, Y.J. | Deposit date: | 2009-09-28 | Release date: | 2010-09-22 | Last modified: | 2014-02-12 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber Embo J., 29, 2010
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6U5Z
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![BU of 6u5z by Molmil](/molmil-images/mine/6u5z) | |
4YPL
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![BU of 4ypl by Molmil](/molmil-images/mine/4ypl) | Crystal structure of a hexameric LonA protease bound to three ADPs | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, N-[(1R)-1-(dihydroxyboranyl)-2-phenylethyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide | Authors: | Lin, C.-C, Chang, C.-I. | Deposit date: | 2015-03-13 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structural Insights into the Allosteric Operation of the Lon AAA+ Protease Structure, 24, 2016
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3M6A
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![BU of 3m6a by Molmil](/molmil-images/mine/3m6a) | |
7KSL
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![BU of 7ksl by Molmil](/molmil-images/mine/7ksl) | Substrate-free human mitochondrial LONP1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-23 | Release date: | 2020-12-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7KSM
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![BU of 7ksm by Molmil](/molmil-images/mine/7ksm) | Human mitochondrial LONP1 with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-23 | Release date: | 2020-12-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7KRZ
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![BU of 7krz by Molmil](/molmil-images/mine/7krz) | Human mitochondrial LONP1 in complex with Bortezomib | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-20 | Release date: | 2021-02-24 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7P0M
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![BU of 7p0m by Molmil](/molmil-images/mine/7p0m) | |
7P09
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![BU of 7p09 by Molmil](/molmil-images/mine/7p09) | |
7P0B
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7P6U
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![BU of 7p6u by Molmil](/molmil-images/mine/7p6u) | Lon protease from Thermus Thermophilus | Descriptor: | (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK), Lon protease, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Coscia, F, Lowe, J. | Deposit date: | 2021-07-18 | Release date: | 2021-10-27 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of the full-length Lon protease from Thermus thermophilus. Febs Lett., 595, 2021
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7OXO
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![BU of 7oxo by Molmil](/molmil-images/mine/7oxo) | human LonP1, R-state, incubated in AMPPCP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. | Deposit date: | 2021-06-22 | Release date: | 2021-12-22 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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6WQH
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![BU of 6wqh by Molmil](/molmil-images/mine/6wqh) | Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... | Authors: | Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. | Deposit date: | 2020-04-28 | Release date: | 2021-06-09 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
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8K3Y
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![BU of 8k3y by Molmil](/molmil-images/mine/8k3y) | The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. | Deposit date: | 2023-07-17 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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8OKA
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![BU of 8oka by Molmil](/molmil-images/mine/8oka) | Human Mitochondrial Lon Y394F Mutant ADP Bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. | Deposit date: | 2023-03-28 | Release date: | 2024-04-10 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
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8OM7
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![BU of 8om7 by Molmil](/molmil-images/mine/8om7) | Human Mitochondrial Lon Y186E Mutant ADP Bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. | Deposit date: | 2023-03-31 | Release date: | 2024-04-10 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
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8OJL
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![BU of 8ojl by Molmil](/molmil-images/mine/8ojl) | Human Mitochondrial Lon Y394E Mutant ADP Bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. | Deposit date: | 2023-03-24 | Release date: | 2024-04-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
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8OVF
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![BU of 8ovf by Molmil](/molmil-images/mine/8ovf) | Human Mitochondrial Lon Y186F Mutant ADP Bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. | Deposit date: | 2023-04-26 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.23 Å) | Cite: | Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
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