PDB: 80 resultsInfo pagesStatus searchChemie searchBIRD

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7XHB	Structure of the SecA/SecYE/proOmpA(4Y)-sfGFP complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein translocase subunit SecA, ... Authors: Dong, L, Li, L. Deposit date: 2022-04-07 Release date: 2023-01-11 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structural basis of SecA-mediated protein translocation. Proc.Natl.Acad.Sci.USA, 120, 2023
2YXR	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2YXQ	The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY Authors: Li, W, Schulman, S. Deposit date: 2007-04-27 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal Mol.Cell, 26, 2007
2ZQP	Crystal Structure of SecYE translocon from Thermus thermophilus Descriptor: Preprotein translocase SecE subunit, Preprotein translocase SecY subunit Authors: Tsukazaki, T, Nureki, O. Deposit date: 2008-08-14 Release date: 2008-10-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (6 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
3BO0	Ribosome-SecY complex Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... Authors: Akey, C.W, Menetret, J.F. Deposit date: 2007-12-15 Release date: 2008-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
3BO1	Ribosome-SecY complex Descriptor: 23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecE SUBUNIT, PREPROTEIN TRANSLOCASE SecY SUBUNIT, ... Authors: Akey, C.W, Menetret, J.F. Deposit date: 2007-12-15 Release date: 2008-12-09 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9.6 Å) Cite: Ribosome binding of a single copy of the SecY complex: implications for protein translocation Mol.Cell, 28, 2007
2ZJS	Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment Descriptor: Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... Authors: Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. Deposit date: 2008-03-08 Release date: 2008-10-14 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
8DNY	Cryo-EM structure of the human Sec61 complex inhibited by decatransin Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNZ	Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO3	Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNX	Cryo-EM structure of the human Sec61 complex inhibited by cotransin Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNV	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DNW	Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2) Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO0	Cryo-EM structure of the human Sec61 complex inhibited by mycolactone Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO1	Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
8DO2	Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... Authors: Park, E, Itskanov, S. Deposit date: 2022-07-12 Release date: 2023-05-24 Last modified: 2023-09-06 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
7AFT	Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon Descriptor: Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... Authors: Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. Deposit date: 2020-09-20 Release date: 2020-12-02 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
6W6L	Cryo-EM structure of the human ribosome-TMCO1 translocon Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Keenan, R.J, McGilvray, P.T. Deposit date: 2020-03-17 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: An ER translocon for multi-pass membrane protein biogenesis. Elife, 9, 2020
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
5NCO	Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome Descriptor: 23S rRNA, 4.5S SRP RNA (Ffs), 50S ribosomal protein L10, ... Authors: Jomaa, A, Hwang Fu, Y, Boerhinger, D, Leibundgut, M, Shan, S.O, Ban, N. Deposit date: 2017-03-06 Release date: 2017-05-24 Last modified: 2018-03-28 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Commun, 8, 2017
6ND1	CryoEM structure of the Sec Complex from yeast Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Wu, X, Cabanos, C, Rapoport, T.A. Deposit date: 2018-12-13 Release date: 2019-01-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of the post-translational protein translocation machinery of the ER membrane. Nature, 566, 2019
5GAE	RNC in complex with a translocating SecYEG Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. Deposit date: 2015-11-25 Release date: 2016-01-27 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
6N3Q	Cryo-EM structure of the yeast Sec complex Descriptor: Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... Authors: Park, E, Itskanov, S. Deposit date: 2018-11-16 Release date: 2018-12-19 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
8OJ8	60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. Deposit date: 2023-03-24 Release date: 2024-02-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024
8OJ0	60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R. Deposit date: 2023-03-23 Release date: 2024-02-21 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. Nature, 627, 2024

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