7U8X
 
 | | hTRAP1 with inhibitors | | Descriptor: | Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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7U8V
 | | hTRAP1 with inhibitors | | Descriptor: | (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.448 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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7U8U
 | | hTRAP1 with inhibitors | | Descriptor: | Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone | | Authors: | Deng, J, Matts, R, Peng, S. | | Deposit date: | 2022-03-09 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.065 Å) | | Cite: | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
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1Y6Z
 | | Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417 | | Descriptor: | heat shock protein, putative | | Authors: | Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC) | | Deposit date: | 2004-12-07 | | Release date: | 2005-02-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
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7KCK
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7EXP
 | | Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ | | Descriptor: | 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ... | | Authors: | Lee, H, Yoon, N.G, Kang, B.H, Lee, C. | | Deposit date: | 2021-05-28 | | Release date: | 2022-01-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.297 Å) | | Cite: | Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
J.Am.Chem.Soc., 143, 2021
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5ULS
 | | Structure of GRP94 in the active conformation | | Descriptor: | Endoplasmin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Huck, J.D, Que, N.L.S, Gewirth, D.T. | | Deposit date: | 2017-01-25 | | Release date: | 2017-09-27 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.622 Å) | | Cite: | Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Cell Rep, 20, 2017
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6D14
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2IOQ
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8EOB
 | | Cryo-EM structure of human HSP90B in the closed state | | Descriptor: | Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Srivastava, D, Artemyev, N.O. | | Deposit date: | 2022-10-02 | | Release date: | 2023-01-25 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
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8EOA
 | | Cryo-EM structure of human HSP90B-AIPL1 complex | | Descriptor: | Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ... | | Authors: | Srivastava, D, Artemyev, N.O. | | Deposit date: | 2022-10-02 | | Release date: | 2023-01-25 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
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2IOP
 | | Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG | | Authors: | Shiau, A.K, Harris, S.F, Agard, D.A. | | Deposit date: | 2006-10-10 | | Release date: | 2006-11-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.55 Å) | | Cite: | Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
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3K60
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2O1V
 | | Structure of full length GRP94 with ADP bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION | | Authors: | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | | Deposit date: | 2006-11-29 | | Release date: | 2007-10-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
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2CG9
 | | Crystal structure of an Hsp90-Sba1 closed chaperone complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1 | | Authors: | Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H. | | Deposit date: | 2006-03-01 | | Release date: | 2006-04-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
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2O1U
 | | Structure of full length GRP94 with AMP-PNP bound | | Descriptor: | Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | | Deposit date: | 2006-11-29 | | Release date: | 2007-10-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
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2O1W
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8U1M
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8U1N
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4IPE
 | | Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP | | Descriptor: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-09 | | Release date: | 2014-01-22 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.289 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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8K2R
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8K2T
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4J0B
 | | Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-30 | | Release date: | 2014-01-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.352 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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5TVU
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4IVG
 | | Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-22 | | Release date: | 2014-01-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.749 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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