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7OQ1	NaK S-ELM mutant with Na+ and K+ Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... Authors: Minniberger, S, Plested, A.J.R. Deposit date: 2021-06-02 Release date: 2022-06-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
7OQ2	NaK S-DI mutant soaked in Na+ Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, POTASSIUM ION, ... Authors: Minniberger, S, Plested, A.J.R. Deposit date: 2021-06-02 Release date: 2022-06-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
7PA0	NaK C-DI F92A mutant with Rb+ and K+ Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... Authors: Minniberger, S, Plested, A.J.R. Deposit date: 2021-07-28 Release date: 2022-08-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors. J.Mol.Biol., 435, 2023
6WCA	Human closed state TMEM175 in KCl Descriptor: Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION Authors: Oh, S, Paknejad, N, Hite, R.K. Deposit date: 2020-03-30 Release date: 2020-04-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
6WC9	Human open state TMEM175 in KCl Descriptor: Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION Authors: Oh, S, Paknejad, N, Hite, R.K. Deposit date: 2020-03-30 Release date: 2020-04-15 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
6UFE	The structure of a potassium selective ion channel at atomic resolution Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Transporter Authors: Langan, P.S, Vandavasi, V.G, Sullivan, B, Afonine, P.V, Weiss, K.L. Deposit date: 2019-09-24 Release date: 2020-08-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The structure of a potassium-selective ion channel reveals a hydrophobic gate regulating ion permeation. Iucrj, 7, 2020
7WF4	Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3, ... Authors: Tyagi, A, Ahmed, T, Jian, S, Bajaj, S, Ong, S.T, Goay, S.S.M, Zhao, Y, Vorobyov, I, Tian, C, Chandy, K.G, Bhushan, S. Deposit date: 2021-12-25 Release date: 2022-02-09 Last modified: 2022-05-25 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc.Natl.Acad.Sci.USA, 119, 2022
5NWK	14-3-3c in complex with CPP and fusicoccin Descriptor: 14-3-3 c-1 protein, FUSICOCCIN, PHOSPHOSERINE, ... Authors: Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. Deposit date: 2017-05-06 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
7WF3	Composite map of human Kv1.3 channel in apo state with beta subunits Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3, ... Authors: Tyagi, A, Ahmed, T, Jian, S, Bajaj, S, Ong, S.T, Goay, S.S.M, Zhao, Y, Vorobyov, I, Tian, C, Chandy, K.G, Bhushan, S. Deposit date: 2021-12-25 Release date: 2022-02-09 Last modified: 2022-05-25 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc.Natl.Acad.Sci.USA, 119, 2022
5A6E	Cryo-EM structure of the Slo2.2 Na-activated K channel Descriptor: GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, ... Authors: Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. Deposit date: 2015-06-25 Release date: 2015-10-14 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
7SK0	TWIK1 in MSP1D1 lipid nanodisc at pH 7.4 Descriptor: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1 Authors: Turney, T.S, Brohawn, S.G. Deposit date: 2021-10-19 Release date: 2021-11-24 Last modified: 2022-06-22 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
7SK1	TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5 Descriptor: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ... Authors: Turney, T.S, Brohawn, S.G. Deposit date: 2021-10-19 Release date: 2021-11-24 Last modified: 2022-06-22 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022
4JTC	Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+ Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. Deposit date: 2013-03-23 Release date: 2013-06-12 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife, 2, 2013
6CNO	Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II Descriptor: CALCIUM ION, Calmodulin-1, Intermediate conductance calcium-activated potassium channel protein 4 Authors: Lee, C.H, MacKinnon, R. Deposit date: 2018-03-08 Release date: 2018-05-02 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science, 360, 2018
5TJ6	Ca2+ bound aplysia Slo1 Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ... Authors: MacKinnon, R, Tao, X, Hite, R.K. Deposit date: 2016-10-03 Release date: 2016-12-14 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
5V03	A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA Descriptor: CALCIUM ION, Calmodulin, N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine, ... Authors: Liu, S. Deposit date: 2017-02-28 Release date: 2018-03-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.58 Å) Cite: An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes. Structure, 26, 2018
7W4P	The structure of KATP H175K mutant in closed state Descriptor: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chen, L, Wang, M. Deposit date: 2021-11-28 Release date: 2022-06-01 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
7W4O	The structure of KATP H175K mutant in pre-open state Descriptor: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Chen, L, Wang, M. Deposit date: 2021-11-28 Release date: 2022-06-01 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
5A6F	Cryo-EM structure of the Slo2.2 Na-activated K channel Descriptor: GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 Authors: Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. Deposit date: 2015-06-25 Release date: 2015-10-14 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
5NWI	14-3-3c in complex with CPP Descriptor: 14-3-3 c-1 protein, ACETATE ION, Potassium channel KAT1 Authors: Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. Deposit date: 2017-05-06 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
5NWJ	14-3-3c in complex with CPP7 Descriptor: 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. Deposit date: 2017-05-06 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
6CZQ	A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model Descriptor: CALCIUM ION, Calmodulin-1, SULFATE ION, ... Authors: Nam, Y.W, Zhang, M. Deposit date: 2018-04-09 Release date: 2018-08-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep, 8, 2018
5A6G	Cryo-EM structure of the Slo2.2 Na-activated K channel Descriptor: PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 Authors: Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. Deposit date: 2015-06-25 Release date: 2015-10-14 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel Nature, 527, 2015
7UNM	Human TMEM175 in an closed state Descriptor: Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION Authors: Oh, S, Hite, R.K. Deposit date: 2022-04-11 Release date: 2022-06-29 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
7UNL	Human TMEM175 in an open state Descriptor: Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION Authors: Oh, S, Hite, R.K. Deposit date: 2022-04-11 Release date: 2022-06-01 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.45 Å) Cite: Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022

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