7NM3
| 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-135 | Descriptor: | 14-3-3 protein sigma, 4-[4-(dimethylamino)piperidin-1-yl]sulfonylbenzaldehyde, CALCIUM ION, ... | Authors: | Wolter, M, Ottmann, C. | Deposit date: | 2021-02-23 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
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5KJI
| Crystal structure of an active polycomb repressive complex 2 in the basal state | Descriptor: | Putative uncharacterized protein,Zinc finger domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | Authors: | Jiao, L, Liu, X. | Deposit date: | 2016-06-20 | Release date: | 2017-04-19 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
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2XN9
| Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II | Descriptor: | ENTEROTOXIN H, GLYCEROL, HEMAGGLUTININ, ... | Authors: | Saline, M, Rodstrom, K.E.J, Fischer, G, Orekhov, V.Y, Karlsson, B.G, Lindkvist-Petersson, K. | Deposit date: | 2010-07-31 | Release date: | 2010-11-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Structure of Superantigen Complexed with Tcr and Mhc Reveals Novel Insights Into Superantigenic T Cell Activation. Nat.Commun., 1, 2010
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4DGL
| Crystal Structure of the CK2 Tetrameric Holoenzyme | Descriptor: | Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION | Authors: | Lolli, G, Battistutta, R. | Deposit date: | 2012-01-26 | Release date: | 2012-05-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization. Acs Chem.Biol., 7, 2012
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2CCH
| The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ... | Authors: | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | Deposit date: | 2006-01-16 | Release date: | 2006-05-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition J.Biol.Chem., 281, 2006
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2CCI
| Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ... | Authors: | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | Deposit date: | 2006-01-16 | Release date: | 2006-05-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J. Biol. Chem., 281, 2006
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7ZTD
| Non-muscle F-actin decorated with non-muscle tropomyosin 3.2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 3.2, actin, ... | Authors: | Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2022-05-09 | Release date: | 2023-01-11 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
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7ZTC
| Non-muscle F-actin decorated with non-muscle tropomyosin 1.6 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Non-muscle tropomyosin 1.6, actin, ... | Authors: | Selvaraj, M, Kokate, S, Kogan, K, Kotila, T, Kremneva, E, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2022-05-09 | Release date: | 2023-01-11 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms. Cell Rep, 42, 2023
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1Q4L
| GSK-3 Beta complexed with Inhibitor I-5 | Descriptor: | 2-CHLORO-5-[4-(3-CHLORO-PHENYL)-2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-3-YLAMINO]-BENZOIC ACID, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-08-04 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors J.Mol.Biol., 333, 2003
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3O6Q
| The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System | Descriptor: | Stage II sporulation protein SA, Stage II sporulation protein SB | Authors: | Levdikov, V.M, Blagova, E.V, Lebedev, A.A, Wilkinson, A.J, Florek, P, Barak, I. | Deposit date: | 2010-07-29 | Release date: | 2010-12-08 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis. J.Biol.Chem., 161, 2010
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7ZMW
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7ZMU
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5UQ3
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1Q3W
| GSK-3 Beta complexed with Alsterpaullone | Descriptor: | 9-NITRO-5,12-DIHYDRO-7H-BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONE, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-08-01 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors J.Mol.Biol., 333, 2003
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1Q41
| GSK-3 Beta complexed with Indirubin-3'-monoxime | Descriptor: | (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-08-01 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors J.Mol.Biol., 333, 2003
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1Q3D
| GSK-3 Beta complexed with Staurosporine | Descriptor: | GLYCOGEN SYNTHASE KINASE-3 BETA, STAUROSPORINE | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-07-29 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Characterization of the Gsk-3Beta Active Site Using Selective and Non-selective ATP-Mimetic Inhibitors J.Mol.Biol., 333, 2003
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1PYX
| GSK-3 Beta complexed with AMP-PNP | Descriptor: | Glycogen synthase kinase-3 beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Bertrand, J.A, Thieffine, S, Vulpetti, A, Cristiani, C, Valsasina, B, Knapp, S, Kalisz, H.M, Flocco, M. | Deposit date: | 2003-07-09 | Release date: | 2003-10-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors J.Mol.Biol., 333, 2003
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2F2C
| X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol | Descriptor: | (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Cell division protein kinase 6, Cyclin homolog, ... | Authors: | Schulze-Gahmen, U, Lu, H. | Deposit date: | 2005-11-16 | Release date: | 2006-06-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006
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4DG2
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4DG0
| Crystal structure of myristoylated WT catalytic subunit of cAMP-dependent protein kinase in complex with SP20 and AMP-PNP | Descriptor: | MAGNESIUM ION, MYRISTIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Bastidas, A.C, Steichen, J.M, Taylor, S.S. | Deposit date: | 2012-01-24 | Release date: | 2012-06-06 | Last modified: | 2013-01-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J.Mol.Biol., 422, 2012
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2EUF
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4DFZ
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1RE8
| Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2 | Descriptor: | 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXYBENZOYL)BENZOATE, N-OCTANE, cAMP-dependent protein kinase, ... | Authors: | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | Deposit date: | 2003-11-06 | Release date: | 2004-02-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit Biochemistry, 43, 2004
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4IQR
| Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... | Authors: | Chandra, V, Huang, P, Kim, Y, Rastinejad, F. | Deposit date: | 2013-01-13 | Release date: | 2013-03-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
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1REJ
| Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1 | Descriptor: | 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE, cAMP-dependent protein kinase, alpha-catalytic subunit | Authors: | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | Deposit date: | 2003-11-06 | Release date: | 2004-02-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit Biochemistry, 43, 2004
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