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6AXR
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BU of 6axr by Molmil
Structure of the P122A mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-07
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.
MBio, 9, 2018
6ATE
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BU of 6ate by Molmil
SRC kinase bound to covalent inhibitor
Descriptor: N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide, Proto-oncogene tyrosine-protein kinase Src
Authors:Gurbani, D, Westover, K.D.
Deposit date:2017-08-28
Release date:2019-02-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
Cell Chem Biol, 26, 2019
6ANL
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BU of 6anl by Molmil
Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors
Descriptor: Mitogen-activated protein kinase 14, TAK-715
Authors:Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C.
Deposit date:2017-08-14
Release date:2018-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg. Med. Chem., 26, 2018
5YWC
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BU of 5ywc by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:Chen, L, Wu, J.X.
Deposit date:2017-11-29
Release date:2018-05-02
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWA
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BU of 5ywa by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Chen, L, Wu, J.X.
Deposit date:2017-11-29
Release date:2018-05-02
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW9
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BU of 5yw9 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Chen, L, Wu, J.X.
Deposit date:2017-11-29
Release date:2018-05-02
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW8
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BU of 5yw8 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
Descriptor: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Chen, L, Wu, J.X.
Deposit date:2017-11-29
Release date:2018-05-02
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YT3
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BU of 5yt3 by Molmil
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant
Descriptor: MAGNESIUM ION, Mitogen-activated protein kinase kinase 1, isoform CRA_d, ...
Authors:Nakae, S, Doko, K, Tada, T, Shirai, T.
Deposit date:2017-11-16
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant
To Be Published
5YKG
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BU of 5ykg by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:Chen, L, Wu, J.X.
Deposit date:2017-10-14
Release date:2018-04-18
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (4.57 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKF
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BU of 5ykf by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:Chen, L, Wu, J.X.
Deposit date:2017-10-14
Release date:2018-04-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.33 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKE
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BU of 5yke by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
Authors:Chen, L, Wu, J.X.
Deposit date:2017-10-14
Release date:2018-04-18
Last modified:2018-06-13
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YI4
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BU of 5yi4 by Molmil
Solution Structure of the DISC1/Ndel1 complex
Descriptor: Disrupted in schizophrenia 1 homolog,Nuclear distribution protein nudE-like 1
Authors:Ye, F, Yu, C, Yu, C, Zhang, M.
Deposit date:2017-10-02
Release date:2017-11-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.
Neuron, 96, 2017
5XYY
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BU of 5xyy by Molmil
The structure of p38 alpha in complex with a triazol inhibitor
Descriptor: 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol, Mitogen-activated protein kinase 14
Authors:Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N.
Deposit date:2017-07-11
Release date:2018-01-17
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
5XYX
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BU of 5xyx by Molmil
The structure of p38 alpha in complex with a triazol inhibitor
Descriptor: Mitogen-activated protein kinase 14, N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine
Authors:Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N.
Deposit date:2017-07-11
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
5WVC
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BU of 5wvc by Molmil
Structure of the CARD-CARD disk
Descriptor: Apoptotic protease-activating factor 1, Caspase, IODIDE ION
Authors:Lin, S.C, Lo, Y.C, Su, T.W.
Deposit date:2016-12-24
Release date:2017-04-19
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.
Structure, 25, 2017
5WUA
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BU of 5wua by Molmil
Structure of a Pancreatic ATP-sensitive Potassium Channel
Descriptor: ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1
Authors:Li, N, Wu, J.-X, Chen, L, Gao, N.
Deposit date:2016-12-16
Release date:2017-01-25
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Structure of a Pancreatic ATP-Sensitive Potassium Channel
Cell, 168, 2017
5WP1
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BU of 5wp1 by Molmil
Complex of ERK2 with 5,7-dihydroxychromone
Descriptor: 5,7-dihydroxy-4H-1-benzopyran-4-one, BENZOIC ACID, Mitogen-activated protein kinase 1, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2017-08-03
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers
To Be Published
5WJJ
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BU of 5wjj by Molmil
Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors
Descriptor: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide
Authors:Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C.
Deposit date:2017-07-23
Release date:2018-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg. Med. Chem., 26, 2018
5W4Q
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BU of 5w4q by Molmil
Structure of the R18A/E28A mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-06-12
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket.
MBio, 10, 2019
5W4P
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BU of 5w4p by Molmil
Structure of the E28A mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-06-12
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket.
MBio, 10, 2019
5W4O
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BU of 5w4o by Molmil
Structure of the R18A mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, Capsid protein p24, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-06-12
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket.
MBio, 10, 2019
5W1F
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BU of 5w1f by Molmil
Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin
Descriptor: CALCIUM ION, NICKEL (II) ION, Protein S100-A8, ...
Authors:Nakashige, T.G, Drennan, C.L, Nolan, E.M.
Deposit date:2017-06-03
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nickel Sequestration by the Host-Defense Protein Human Calprotectin.
J. Am. Chem. Soc., 139, 2017
5VVT
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BU of 5vvt by Molmil
Structural Investigations of the Substrate Specificity of Human O-GlcNAcase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ELK1 peptide, Protein O-GlcNAcase
Authors:Li, B, Jiang, J, Li, H, Hu, C.-W.
Deposit date:2017-05-20
Release date:2017-09-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.
Nat Commun, 8, 2017
5V62
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BU of 5v62 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP3
Descriptor: 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V61
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BU of 5v61 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP2
Descriptor: 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017

221716

数据于2024-06-26公开中

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