PDB: 46220 resultsInfo pagesStatus searchChemie searchBIRD

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2O8P	Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470 Descriptor: 14-3-3 domain containing protein Authors: Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC) Deposit date: 2006-12-12 Release date: 2007-01-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2020-02-21 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Ottmann, C. Deposit date: 2021-12-14 Release date: 2022-05-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 Authors: Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. Deposit date: 2017-11-17 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018
6HEP	Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Ottmann, C, Brunsveld, L. Deposit date: 2018-08-20 Release date: 2018-10-24 Last modified: 2018-11-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. J. Am. Chem. Soc., 140, 2018
5D2D	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-05 Release date: 2016-03-16 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... Authors: Ding, S, Shi, Z.B. Deposit date: 2015-04-18 Release date: 2015-09-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNB	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNA	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
4DAT	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI Authors: Rose, R, Rose, M, Ottmann, C. Deposit date: 2012-01-13 Release date: 2012-06-13 Last modified: 2012-10-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
6YOS	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-15 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6FN9	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GLYCEROL, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
4DAU	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I Descriptor: 14-3-3 protein sigma, Peptidylarginine Deiminase type VI Authors: Rose, R, Rose, M, Ottmann, C. Deposit date: 2012-01-13 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
8CHF	cryo-EM Structure of Craf:14-3-3:Mek1 Descriptor: 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Dedden, D, Ulrich, G. Deposit date: 2023-02-07 Release date: 2024-02-21 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.25 Å) Cite: Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8CPD	Cryo-EM structure of CRaf dimer with 14:3:3 Descriptor: 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase Authors: Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. Deposit date: 2023-03-02 Release date: 2024-02-21 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
4DX0	Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative Descriptor: 14-3-3-like protein E, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA Authors: Richter, A, Rose, R, Hedberg, C, Waldmann, H, Ottmann, C. Deposit date: 2012-02-27 Release date: 2012-05-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.4 Å) Cite: An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction. Chemistry, 18, 2012
7PWZ	Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 Descriptor: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... Authors: Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. Deposit date: 2021-10-07 Release date: 2022-12-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-14 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-09 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015

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