PDB: 47998 resultsInfo pagesStatus searchChemie searchBIRD

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7BG3	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2046 Descriptor: 1-(3-bromanyl-4-methyl-phenyl)-2-(2-bromophenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. Deposit date: 2021-01-05 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
3E6Y	Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2008-08-17 Release date: 2009-03-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
4F7R	Crystal structure of 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein, SULFATE ION Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2012-05-16 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The Crystal Structure of Giardia duodenalis 14-3-3 in the Apo Form: When Protein Post-Translational Modifications Make the Difference. Plos One, 9, 2014
6W0L	Henipavirus W protein interacts with 14-3-3 to modulate host gene expression Descriptor: 14-3-3 protein sigma, CALCIUM ION, Phosphorylated W peptide Authors: Edwards, M, Hoad, M, Tsimbalyuk, S, Menicucci, A, Messaoudi, I, Forwood, J, Basler, C. Deposit date: 2020-03-01 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression. J.Virol., 94, 2020
1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Ottmann, C. Deposit date: 2021-12-14 Release date: 2022-05-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
1O9D	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
6BYK	Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide Descriptor: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6BYL	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSASTTVPVTTATTTTTSTW O-GlcNac peptide Authors: Schumacher, M.A. Deposit date: 2017-12-20 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide Authors: Schumacher, M.A. Deposit date: 2017-12-22 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
7BJF	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-069 Descriptor: (5-methyl-2-nitro-phenyl) cyclobutanecarboxylate, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-01-14 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BIY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 Descriptor: 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-01-13 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2020-02-21 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
5LTW	Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6 Descriptor: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6, ... Authors: Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. Deposit date: 2016-09-07 Release date: 2017-02-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
5LU2	Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide Descriptor: 14-3-3 protein sigma, Heat shock protein beta-6 Authors: Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. Deposit date: 2016-09-07 Release date: 2017-02-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
5N10	Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform Descriptor: 14-3-3 protein beta/alpha, Cucurbit[8]uril, Estrogen receptor, ... Authors: de Vink, P.J, Ottmann, C. Deposit date: 2017-02-04 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3. Angew. Chem. Int. Ed. Engl., 56, 2017
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 Authors: Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. Deposit date: 2017-11-17 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018

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