PDB: 658 resultsInfo pagesStatus searchChemie searchBIRD

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1OY9	Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump Descriptor: Acriflavine resistance protein B, ETHIDIUM Authors: Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. Deposit date: 2003-04-03 Release date: 2003-05-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
1OYD	Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump Descriptor: Acriflavine resistance protein B, DEQUALINIUM Authors: Yu, E.W, MeDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. Deposit date: 2003-04-03 Release date: 2003-05-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
6BZS	Human ABCC6 NBD1 in Apo state Descriptor: Multidrug resistance-associated protein 6, SULFATE ION Authors: Zheng, A, Thibodeau, P.H. Deposit date: 2017-12-26 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.29990458 Å) Cite: Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter. J. Biol. Chem., 293, 2018
4ZLL	Crystal structure of transporter AcrB triple mutant Descriptor: Multidrug efflux pump subunit AcrB Authors: Ababou, A, Koronakis, V. Deposit date: 2015-05-01 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.36 Å) Cite: Crystal structure of transporter AcrB triple mutant To Be Published
4ZLJ	Crystal structure of transporter AcrB Descriptor: Multidrug efflux pump subunit AcrB Authors: Ababou, A, Koronakis, V. Deposit date: 2015-05-01 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.257 Å) Cite: Crystal structure of transporter AcrB To Be Published
4ZLN	Crystal structure of transporter AcrB deletion mutant Descriptor: Multidrug efflux pump subunit AcrB Authors: Ababou, A, Koronakis, V. Deposit date: 2015-05-01 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.557 Å) Cite: Crystal structure of transporter AcrB deletion mutant To Be Published
5AZO	Crystal structure of a membrane protein from Pseudomonas aeruginosa Descriptor: Multidrug efflux outer membrane protein OprN Authors: Yonehara, R, Yamashita, E, Nakagawa, A. Deposit date: 2015-10-21 Release date: 2016-06-08 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structures of OprN and OprJ, outer membrane factors of multidrug tripartite efflux pumps of Pseudomonas aeruginosa. Proteins, 84, 2016
5NIK	Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump Descriptor: Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC Authors: Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. Deposit date: 2017-03-24 Release date: 2017-05-24 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
5NIL	Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump-MacB section Descriptor: Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC Authors: Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. Deposit date: 2017-03-24 Release date: 2017-05-24 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (5.3 Å) Cite: Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
7M33	The structure of Bacillus subtilis BmrCD in the inward-facing conformation bound to Hoechst-33342 and ATP Descriptor: 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... Authors: Thaker, T.M, Tomasiak, T.M. Deposit date: 2021-03-18 Release date: 2022-01-05 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Nat.Chem.Biol., 18, 2022
8F4B	Bovine multidrug resistance protein 1 (MRP1) bound to cyclic peptide inhibitor 1 (CPI1) Descriptor: Cyclic peptide inhibitor 1 (CPI1), Multidrug resistance-associated protein 1 Authors: Pietz, H.L, Chen, J. Deposit date: 2022-11-10 Release date: 2023-03-22 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proc.Natl.Acad.Sci.USA, 120, 2023
1IWG	Crystal structure of Bacterial Multidrug Efflux transporter AcrB Descriptor: AcrB Authors: Murakami, S, Nakashima, R, Yamashita, E, Yamaguchi, A. Deposit date: 2002-05-15 Release date: 2002-10-23 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Crystal structure of bacterial multidrug efflux transporter AcrB NATURE, 419, 2002
7OUK	BDM88855 inhibitor bound to the transmembrane domain of AcrB Descriptor: (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ... Authors: Tam, H.K, Foong, W.E, Pos, K.M. Deposit date: 2021-06-12 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
7OUL	BDM88832 inhibitor bound to the transmembrane domain of AcrB-R971A Descriptor: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 1-(3-chloranyl-5-iodanyl-pyridin-2-yl)piperazine, ... Authors: Tam, H.K, Foong, W.E, Pos, K.M. Deposit date: 2021-06-12 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
7OUM	BDM88855 inhibitor bound to the transmembrane domain of AcrB-R971A Descriptor: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, 3-chloranyl-2-piperazin-1-yl-quinoline, ... Authors: Tam, H.K, Foong, W.E, Pos, K.M. Deposit date: 2021-06-12 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun, 13, 2022
5NC5	Crystal structure of AcrBZ in complex with antibiotic puromycin Descriptor: DARPin, DECANE, DODECANE, ... Authors: Du, D, Luisi, B. Deposit date: 2017-03-03 Release date: 2017-04-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
8SX9	Inward-facing narrow conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc Descriptor: Multidrug resistance-associated protein 4 Authors: Pourmal, S, Stroud, R.M. Deposit date: 2023-05-20 Release date: 2024-01-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of prostaglandin efflux by MRP4. Nat.Struct.Mol.Biol., 31, 2024
8SXA	Inward-facing wide conformation of bovine multidrug resistance protein 4 (MRP4) in MSP lipid nanodisc Descriptor: Multidrug resistance-associated protein 4 Authors: Pourmal, S, Stroud, R.M. Deposit date: 2023-05-20 Release date: 2024-01-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of prostaglandin efflux by MRP4. Nat.Struct.Mol.Biol., 31, 2024
6CSX	Single particles Cryo-EM structure of AcrB D407A associated with lipid bilayer at 3.0 Angstrom Descriptor: DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE Authors: Qiu, W, Fu, Z, Guo, Y. Deposit date: 2018-03-21 Release date: 2018-12-05 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure and activity of lipid bilayer within a membrane-protein transporter. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5XJJ	Crystal structure of a MATE family protein Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, multi drug efflux transporter Authors: Tanaka, Y, Tsukazaki, T, Iwaki, S. Deposit date: 2017-05-02 Release date: 2017-09-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein Structure, 25, 2017
6BAJ	Cryo-EM structure of lipid bilayer in the native cell membrane nanoparticles of AcrB Descriptor: DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE Authors: Qiu, W, Fu, Z, Guo, Y. Deposit date: 2017-10-13 Release date: 2018-12-19 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure and activity of lipid bilayer within a membrane-protein transporter. Proc.Natl.Acad.Sci.USA, 115, 2018
6SGR	Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc with cardiolipin Descriptor: DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB Authors: Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. Deposit date: 2019-08-05 Release date: 2020-05-13 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.17 Å) Cite: Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
5YCK	Crystal structure of a MATE family protein derived from Camelina sativa at 2.3 angstrom Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, RUBIDIUM ION, multi drug efflux transporter Authors: Tanaka, Y, Tsukazaki, T, Iwaki, S. Deposit date: 2017-09-07 Release date: 2017-09-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein Structure, 25, 2017
6SGS	Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc Descriptor: DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB Authors: Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. Deposit date: 2019-08-05 Release date: 2020-05-13 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
5LQ3	Structures and transport dynamics of the Campylobacter jejuni multidrug efflux pump CmeB Descriptor: CmeB Authors: Su, C.C. Deposit date: 2016-08-15 Release date: 2017-08-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.55 Å) Cite: Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump. Nat Commun, 8, 2017

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