7DSL
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![BU of 7dsl by Molmil](/molmil-images/mine/7dsl) | Overall structure of the LAT1-4F2hc bound with JX-078 | Descriptor: | (2~{S})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | Deposit date: | 2020-12-31 | Release date: | 2021-03-10 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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7DSK
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![BU of 7dsk by Molmil](/molmil-images/mine/7dsk) | Overall structure of the LAT1-4F2hc bound with JX-075 | Descriptor: | (2~{S})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | Deposit date: | 2020-12-31 | Release date: | 2021-03-10 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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7DSN
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![BU of 7dsn by Molmil](/molmil-images/mine/7dsn) | Overall structure of the LAT1-4F2hc bound with JX-119 | Descriptor: | (2~{S})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | Deposit date: | 2020-12-31 | Release date: | 2021-03-10 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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8IDA
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![BU of 8ida by Molmil](/molmil-images/mine/8ida) | Overall structure of the LAT1-4F2hc bound with tyrosine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Large neutral amino acids transporter small subunit 1, ... | Authors: | Yan, R.H, Li, Y.N, Shi, T.H. | Deposit date: | 2023-02-12 | Release date: | 2024-07-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Overall structure of the LAT1-4F2hc bound with tyrosine To Be Published
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8XPU
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![BU of 8xpu by Molmil](/molmil-images/mine/8xpu) | Overall structure of the LAT1-4F2hc bound with JPH203 | Descriptor: | (2~{S})-2-azanyl-3-[4-[(5-azanyl-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-bis(chloranyl)phenyl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 5 of Amino acid transporter heavy chain SLC3A2, ... | Authors: | Hu, Z, Yan, R. | Deposit date: | 2024-01-04 | Release date: | 2024-07-17 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203. Cell Discov, 10, 2024
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6IRS
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![BU of 6irs by Molmil](/molmil-images/mine/6irs) | human LAT1-4F2hc complex incubated with JPH203 | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | Authors: | Yan, R.H, Zhao, X, Lei, J.L, Zhou, Q. | Deposit date: | 2018-11-14 | Release date: | 2019-03-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature, 568, 2019
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6JMQ
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![BU of 6jmq by Molmil](/molmil-images/mine/6jmq) | LAT1-CD98hc complex bound to MEM-108 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | Authors: | Lee, Y, Nishizawa, T, Kusakizako, T, Oda, K, Ishitani, R, Nakane, T, Nureki, O. | Deposit date: | 2019-03-13 | Release date: | 2019-06-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc. Nat.Struct.Mol.Biol., 26, 2019
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7DSQ
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![BU of 7dsq by Molmil](/molmil-images/mine/7dsq) | Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIIODOTYROSINE, ... | Authors: | Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q. | Deposit date: | 2020-12-31 | Release date: | 2021-03-10 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov, 7, 2021
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6IRT
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![BU of 6irt by Molmil](/molmil-images/mine/6irt) | human LAT1-4F2hc complex bound with BCH | Descriptor: | (1S,2S,4R)-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R.H, Zhao, X, Lei, J.L, Zhou, Q. | Deposit date: | 2018-11-14 | Release date: | 2019-03-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature, 568, 2019
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8J8L
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![BU of 8j8l by Molmil](/molmil-images/mine/8j8l) | Overall structure of the LAT1-4F2hc bound with L-dopa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-DIHYDROXYPHENYLALANINE, 4F2 cell-surface antigen heavy chain, ... | Authors: | Yan, R.H, Li, Y.N, Shi, T.H. | Deposit date: | 2023-05-02 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Overall structure of the LAT1-4F2hc bound with L-dopa To Be Published
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8J8M
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![BU of 8j8m by Molmil](/molmil-images/mine/8j8m) | Overall structure of the LAT1-4F2hc bound with tryptophan | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Large neutral amino acids transporter small subunit 1, ... | Authors: | Yan, R.H, Li, Y.N, Shi, T.H. | Deposit date: | 2023-05-02 | Release date: | 2024-07-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Overall structure of the LAT1-4F2hc bound with tryptophan To Be Published
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