5XA8
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![BU of 5xa8 by Molmil](/molmil-images/mine/5xa8) | Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E1-ALF4-ADP-2CA2+ crystals | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | Deposit date: | 2017-03-11 | Release date: | 2017-05-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XAA
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![BU of 5xaa by Molmil](/molmil-images/mine/5xaa) | Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2-ALF-(TG) crystals of P21212 symmetry | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | Deposit date: | 2017-03-11 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5ZMV
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![BU of 5zmv by Molmil](/molmil-images/mine/5zmv) | Crystal structure of the E309A mutant of SR Ca2+-ATPase in E2(TG) | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Ogawa, H, Hirata, A, Tsueda, J, Toyoshima, C. | Deposit date: | 2018-04-06 | Release date: | 2018-12-12 | Last modified: | 2018-12-26 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Mechanism of the E2 to E1 transition in Ca2+pump revealed by crystal structures of gating residue mutants. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2DQS
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![BU of 2dqs by Molmil](/molmil-images/mine/2dqs) | |
2BY4
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![BU of 2by4 by Molmil](/molmil-images/mine/2by4) | SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT. | Descriptor: | (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Jensen, A.L, Moller, J.V, Soehoel, H, Denmeade, S.R, Isaacs, J.T, Olsen, C.E, Christensen, S.B, Nissen, P. | Deposit date: | 2005-07-28 | Release date: | 2006-04-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells Bioorg.Med.Chem., 14, 2006
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2C88
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![BU of 2c88 by Molmil](/molmil-images/mine/2c88) | Crystal Structure Of (SR) Calcium-ATPase E2(Tg):AMPPCP form | Descriptor: | MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-02 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2C8L
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![BU of 2c8l by Molmil](/molmil-images/mine/2c8l) | Crystal Structure of (SR) Calcium-ATPase E2(Tg) form | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-06 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2C8K
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![BU of 2c8k by Molmil](/molmil-images/mine/2c8k) | Crystal Structure of (SR) Calcium-ATPase E2(Tg) with partially occupied AMPPCP site | Descriptor: | ARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Jensen, A.M, Sorensen, T.L, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-06 | Release date: | 2006-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2AGV
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![BU of 2agv by Molmil](/molmil-images/mine/2agv) | Crystal structure of the SR CA2+-ATPASE with BHQ and TG | Descriptor: | 2,5-DITERT-BUTYLBENZENE-1,4-DIOL, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Toyoshima, C, Obara, K, Norimatsu, Y. | Deposit date: | 2005-07-27 | Release date: | 2005-10-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inaugural Article: Structural role of countertransport revealed in Ca2+ pump crystal structure in the absence of Ca2+. Proc.Natl.Acad.Sci.USA, 102, 2005
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2C9M
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![BU of 2c9m by Molmil](/molmil-images/mine/2c9m) | Structure of (SR) Calcium-ATPase in the Ca2E1 state solved in a P1 crystal form. | Descriptor: | CALCIUM ION, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Lund Jensen, A.-M, Sorensen, T.L.-M, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-13 | Release date: | 2006-12-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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2EAU
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![BU of 2eau by Molmil](/molmil-images/mine/2eau) | Crystal structure of the SR CA2+-ATPASE with bound CPA in the presence of curcumin | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, PHOSPHATIDYLETHANOLAMINE, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2EAR
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![BU of 2ear by Molmil](/molmil-images/mine/2ear) | P21 crystal of the SR CA2+-ATPase with bound TG | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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2EAT
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![BU of 2eat by Molmil](/molmil-images/mine/2eat) | Crystal structure of the SR CA2+-ATPASE with bound CPA and TG | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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8IJM
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![BU of 8ijm by Molmil](/molmil-images/mine/8ijm) | Cyo-EM structure of K794A non-gastric proton pump in Na+ bound E1AMPPCP state | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Abe, K. | Deposit date: | 2023-02-27 | Release date: | 2023-08-02 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | An unusual conformation from Na + -sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na + -binding. Biochim Biophys Acta Mol Cell Res, 1870, 2023
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8IJX
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![BU of 8ijx by Molmil](/molmil-images/mine/8ijx) | Cryo-EM structure of the gastric proton pump with bound DQ-18 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[(5-chloranyl-2-phenylmethoxy-phenyl)methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | Deposit date: | 2023-02-28 | Release date: | 2023-08-30 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.08 Å) | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
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8IJW
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![BU of 8ijw by Molmil](/molmil-images/mine/8ijw) | Cryo-EM structure of the gastric proton pump with bound DQ-06 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | Deposit date: | 2023-02-28 | Release date: | 2023-08-30 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.19 Å) | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
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8IJV
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![BU of 8ijv by Molmil](/molmil-images/mine/8ijv) | Cryo-EM structure of the gastric proton pump with bound DQ-02 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[5-chloranyl-2-(4-chlorophenyl)phenyl]methoxy]-N-methyl-but-2-yn-1-amine, ... | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | Deposit date: | 2023-02-28 | Release date: | 2023-08-30 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
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8IJL
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![BU of 8ijl by Molmil](/molmil-images/mine/8ijl) | Cyo-EM structure of wildtype non-gastric proton pump in the presence of Na+, AlF and ADP | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... | Authors: | Abe, K. | Deposit date: | 2023-02-27 | Release date: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | An unusual conformation from Na + -sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na + -binding. Biochim Biophys Acta Mol Cell Res, 1870, 2023
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8JFZ
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![BU of 8jfz by Molmil](/molmil-images/mine/8jfz) | Cryo-EM structure of Na+,K+-ATPase in the E1.Mg2+ state. | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | Deposit date: | 2023-05-19 | Release date: | 2023-08-09 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate. Febs Lett., 597, 2023
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8JBM
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![BU of 8jbm by Molmil](/molmil-images/mine/8jbm) | Crystal structure of Na+,K+-ATPase in the E1.Mn2+ state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | Deposit date: | 2023-05-09 | Release date: | 2023-08-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate. Febs Lett., 597, 2023
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8JBL
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![BU of 8jbl by Molmil](/molmil-images/mine/8jbl) | Crystal structure of Na+,K+-ATPase in the E1.Mg2+ state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | Deposit date: | 2023-05-09 | Release date: | 2023-08-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate. Febs Lett., 597, 2023
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8JBK
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![BU of 8jbk by Molmil](/molmil-images/mine/8jbk) | Crystal structure of Na+,K+-ATPase in the E1.3Na+ state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C. | Deposit date: | 2023-05-09 | Release date: | 2023-08-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate. Febs Lett., 597, 2023
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8JMN
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![BU of 8jmn by Molmil](/molmil-images/mine/8jmn) | Cryo-EM structure of the gastric proton pump with bound DQ-21 | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[[2-[(4-chlorophenyl)methoxy]phenyl]methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abe, K, Yokoshima, S, Yoshimori, A. | Deposit date: | 2023-06-05 | Release date: | 2023-08-30 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
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8IWT
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![BU of 8iwt by Molmil](/molmil-images/mine/8iwt) | hSPCA1 in the early E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWU
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![BU of 8iwu by Molmil](/molmil-images/mine/8iwu) | hSPCA1 in the E2~P state | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | Deposit date: | 2023-03-31 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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