6YE9
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![BU of 6ye9 by Molmil](/molmil-images/mine/6ye9) | Small-molecule inhibitor of 14-3-3 protein-protein interactions | Descriptor: | 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid | Authors: | Ottmann, C, Visser, E.J. | Deposit date: | 2020-03-24 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions To Be Published
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6Y7T
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6YIA
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6YIC
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6YIB
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6YR7
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![BU of 6yr7 by Molmil](/molmil-images/mine/6yr7) | 14-3-3 sigma in complex with hDMX-342+367 peptide | Descriptor: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 | Authors: | Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. | Deposit date: | 2020-04-19 | Release date: | 2021-11-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
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6YR5
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![BU of 6yr5 by Molmil](/molmil-images/mine/6yr5) | 14-3-3 sigma in complex with hDMX-367 peptide | Descriptor: | 14-3-3 protein sigma, Protein Mdm4, SULFATE ION | Authors: | Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A. | Deposit date: | 2020-04-19 | Release date: | 2021-11-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
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6YR6
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![BU of 6yr6 by Molmil](/molmil-images/mine/6yr6) | 14-3-3 sigma in complex with hDM2-186 peptide | Descriptor: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... | Authors: | Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. | Deposit date: | 2020-04-19 | Release date: | 2021-11-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
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6ZCJ
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![BU of 6zcj by Molmil](/molmil-images/mine/6zcj) | 14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure | Descriptor: | 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 | Authors: | Soini, L, Leysen, S, Davis, J, Ottmann, C. | Deposit date: | 2020-06-11 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
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6XWD
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6XXC
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![BU of 6xxc by Molmil](/molmil-images/mine/6xxc) | Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 4 | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, Estrogen Related Receptor gamma phosphopeptide, ... | Authors: | Somsen, B.A, Ottmann, C. | Deposit date: | 2020-01-27 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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6Y3O
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![BU of 6y3o by Molmil](/molmil-images/mine/6y3o) | 14-3-3 Sigma in complex with phosphorylated CAMKK2 peptide | Descriptor: | 14-3-3 protein sigma, CALCIUM ION, CAMKK2, ... | Authors: | Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. | Deposit date: | 2020-02-18 | Release date: | 2020-10-14 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
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6Y3W
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![BU of 6y3w by Molmil](/molmil-images/mine/6y3w) | Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 1 | Descriptor: | 14-3-3 protein sigma, 3-fluoranyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... | Authors: | Somsen, B.A, Ottmann, C. | Deposit date: | 2020-02-19 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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6ZFD
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![BU of 6zfd by Molmil](/molmil-images/mine/6zfd) | 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus | Descriptor: | 14-3-3 protein zeta/delta,Protein E6, GLYCEROL | Authors: | Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. | Deposit date: | 2020-06-17 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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6ZFG
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![BU of 6zfg by Molmil](/molmil-images/mine/6zfg) | 14-3-3 zeta chimera with 18E6 and fusicoccin | Descriptor: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | Authors: | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | Deposit date: | 2020-06-17 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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8BWH
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8BTQ
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8BWE
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8C3C
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8C2G
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8C2D
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![BU of 8c2d by Molmil](/molmil-images/mine/8c2d) | 14-3-3 in complex with Pyrin pS208 | Descriptor: | 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide | Authors: | Lau, R, Ottmann, C, Hann, M. | Deposit date: | 2022-12-22 | Release date: | 2023-07-26 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
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8BYO
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![BU of 8byo by Molmil](/molmil-images/mine/8byo) | fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) | Descriptor: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | Authors: | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | Deposit date: | 2023-01-18 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZW
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![BU of 8bzw by Molmil](/molmil-images/mine/8bzw) | Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210) | Descriptor: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ... | Authors: | Visser, E.J, Sijbesma, E, Ottmann, C. | Deposit date: | 2022-12-15 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYE
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8BYB
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