6LQV
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![BU of 6lqv by Molmil](/molmil-images/mine/6lqv) | |
6LQT
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![BU of 6lqt by Molmil](/molmil-images/mine/6lqt) | |
6LQQ
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![BU of 6lqq by Molmil](/molmil-images/mine/6lqq) | |
6MDO
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![BU of 6mdo by Molmil](/molmil-images/mine/6mdo) | The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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6LQP
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![BU of 6lqp by Molmil](/molmil-images/mine/6lqp) | |
6LQU
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![BU of 6lqu by Molmil](/molmil-images/mine/6lqu) | |
6MAT
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![BU of 6mat by Molmil](/molmil-images/mine/6mat) | Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein | Authors: | Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E. | Deposit date: | 2018-08-28 | Release date: | 2019-02-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7. Nat Commun, 10, 2019
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6MDN
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![BU of 6mdn by Molmil](/molmil-images/mine/6mdn) | The 20S supercomplex engaging the SNAP-25 N-terminus (class 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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6MDM
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![BU of 6mdm by Molmil](/molmil-images/mine/6mdm) | The 20S supercomplex engaging the SNAP-25 N-terminus (class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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6MCK
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![BU of 6mck by Molmil](/molmil-images/mine/6mck) | p97 D1D2 with CB5083 bound | Descriptor: | 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2018-08-31 | Release date: | 2019-01-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.77 Å) | Cite: | Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083. Mol. Pharmacol., 95, 2019
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6MSJ
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![BU of 6msj by Molmil](/molmil-images/mine/6msj) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6MSG
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![BU of 6msg by Molmil](/molmil-images/mine/6msg) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6MSE
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![BU of 6mse by Molmil](/molmil-images/mine/6mse) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6N8V
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![BU of 6n8v by Molmil](/molmil-images/mine/6n8v) | Hsp104DWB open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | Authors: | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | Deposit date: | 2018-11-30 | Release date: | 2019-01-02 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (9.3 Å) | Cite: | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation. Cell Rep, 26, 2019
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6MSB
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![BU of 6msb by Molmil](/molmil-images/mine/6msb) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6MSK
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![BU of 6msk by Molmil](/molmil-images/mine/6msk) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6MSH
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![BU of 6msh by Molmil](/molmil-images/mine/6msh) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-11-21 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6NYV
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![BU of 6nyv by Molmil](/molmil-images/mine/6nyv) | Structure of spastin AAA domain in complex with a quinazoline-based inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, N-(3-tert-butyl-1H-pyrazol-5-yl)-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, SULFATE ION, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-02-12 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.425 Å) | Cite: | Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141, 2019
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6NYY
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![BU of 6nyy by Molmil](/molmil-images/mine/6nyy) | human m-AAA protease AFG3L2, substrate-bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ... | Authors: | Lander, G.C, Puchades, C. | Deposit date: | 2019-02-12 | Release date: | 2019-05-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Mol.Cell, 75, 2019
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6NDY
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![BU of 6ndy by Molmil](/molmil-images/mine/6ndy) | Vps4 with Cyclic Peptide Bound in the Central Pore | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | Authors: | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | Deposit date: | 2018-12-14 | Release date: | 2019-08-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8, 2019
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6NYW
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![BU of 6nyw by Molmil](/molmil-images/mine/6nyw) | Structure of spastin AAA domain N527C mutant in complex with 8-fluoroquinazoline-based inhibitor | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, N-(5-tert-butyl-1H-pyrazol-3-yl)-8-fluoro-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, ... | Authors: | Pisa, R, Cupido, T, Kapoor, T.M. | Deposit date: | 2019-02-12 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.189 Å) | Cite: | Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141, 2019
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6MSD
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![BU of 6msd by Molmil](/molmil-images/mine/6msd) | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | Authors: | Mao, Y.D. | Deposit date: | 2018-10-16 | Release date: | 2018-12-05 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
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6N8T
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![BU of 6n8t by Molmil](/molmil-images/mine/6n8t) | Hsp104DWB closed conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 104 | Authors: | Lee, S, Rho, S.H, Lee, J, Sung, N, Liu, J, Tsai, F.T.F. | Deposit date: | 2018-11-30 | Release date: | 2019-01-02 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation. Cell Rep, 26, 2019
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6OA9
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![BU of 6oa9 by Molmil](/molmil-images/mine/6oa9) | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ... | Authors: | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | Deposit date: | 2019-03-15 | Release date: | 2019-07-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OMB
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![BU of 6omb by Molmil](/molmil-images/mine/6omb) | Cdc48 Hexamer (Subunits A to E) with substrate bound to the central pore | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | Authors: | Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S. | Deposit date: | 2019-04-18 | Release date: | 2019-07-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Science, 365, 2019
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