6NYW
Structure of spastin AAA domain N527C mutant in complex with 8-fluoroquinazoline-based inhibitor
Summary for 6NYW
| Entry DOI | 10.2210/pdb6nyw/pdb |
| Related | 6NYV |
| Descriptor | Spastin, SULFATE ION, N-(5-tert-butyl-1H-pyrazol-3-yl)-8-fluoro-2-[(2R)-2-methylpiperazin-1-yl]quinazolin-4-amine, ... (6 entities in total) |
| Functional Keywords | aaa+ protein, hydrolase, enzyme-inhibitor complex, isomerase-inhibitor complex, isomerase/inhibitor |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Total number of polymer chains | 1 |
| Total formula weight | 35144.04 |
| Authors | Pisa, R.,Cupido, T.,Kapoor, T.M. (deposition date: 2019-02-12, release date: 2019-03-27, Last modification date: 2023-10-11) |
| Primary citation | Pisa, R.,Cupido, T.,Kapoor, T.M. Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141:5602-5606, 2019 Cited by PubMed: 30875216DOI: 10.1021/jacs.8b13257 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.189 Å) |
Structure validation
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