1YDL
| Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045. | Descriptor: | general transcription factor IIH, polypeptide 5 | Authors: | Forouhar, F, Edstrom, W, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-12-24 | Release date: | 2005-02-08 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045. To be Published
|
|
2JNJ
| Solution structure of the p8 TFIIH subunit | Descriptor: | TFIIH basal transcription factor complex TTD-A subunit | Authors: | Vitorino, M, Atkinson, R.A, Moras, D, Poterszman, A, Kieffer, B, Structural Proteomics in Europe 2 (SPINE-2) | Deposit date: | 2007-01-26 | Release date: | 2007-04-10 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Solution Structure and Self-association Properties of the p8 TFIIH Subunit Responsible for Trichothiodystrophy J.Mol.Biol., 368, 2007
|
|
3DGP
| Crystal Structure of the complex between Tfb5 and the C-terminal domain of Tfb2 | Descriptor: | RNA polymerase II transcription factor B subunit 2, RNA polymerase II transcription factor B subunit 5 | Authors: | Kainov, D.E, Cavarelli, J, Egly, J.M, Poterszman, A. | Deposit date: | 2008-06-14 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for group A trichothiodystrophy Nat.Struct.Mol.Biol., 15, 2008
|
|
3DOM
| Crystal Structure of the complex between Tfb5 and the C-terminal domain of Tfb2 | Descriptor: | RNA polymerase II transcription factor B subunit 2, RNA polymerase II transcription factor B subunit 5 | Authors: | Kainov, D.E, Cavarelli, J, Egly, J.M, Poterszman, A. | Deposit date: | 2008-07-04 | Release date: | 2008-08-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for group A trichothiodystrophy Nat.Struct.Mol.Biol., 15, 2008
|
|
6TRS
| Crystal structure of TFIIH subunit p52 in complex with p8 | Descriptor: | RNA polymerase II transcription factor B subunit 2, Uncharacterized protein | Authors: | Koelmel, W, Kuper, J, Schoenwetter, E, Kisker, C. | Deposit date: | 2019-12-19 | Release date: | 2020-10-21 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | How to limit the speed of a motor: the intricate regulation of the XPB ATPase and translocase in TFIIH. Nucleic Acids Res., 48, 2020
|
|
5SVA
| Mediator-RNA Polymerase II Pre-Initiation Complex | Descriptor: | 108bp HIS4 Promoter Non-template Strand (-92/+16), 108bp HIS4 Promoter Template Strand (+16/-92), DNA repair helicase RAD25, ... | Authors: | Robinson, P.J, Bushnell, D.A, Kornberg, R.D. | Deposit date: | 2016-08-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (15.3 Å) | Cite: | Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex. Cell, 166, 2016
|
|
6RO4
| Structure of the core TFIIH-XPA-DNA complex | Descriptor: | DNA repair protein complementing XP-A cells, DNA1, DNA2, ... | Authors: | Kokic, G, Chernev, A, Tegunov, D, Dienemann, C, Urlaub, H, Cramer, P. | Deposit date: | 2019-05-10 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TFIIH activation for nucleotide excision repair. Nat Commun, 10, 2019
|
|
6GYM
| Structure of a yeast closed complex with distorted DNA (CCdist) | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Dienemann, C, Schwalb, B, Schilbach, S, Cramer, P. | Deposit date: | 2018-06-30 | Release date: | 2018-12-05 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Promoter Distortion and Opening in the RNA Polymerase II Cleft. Mol. Cell, 73, 2019
|
|
7AD8
| Core TFIIH-XPA-DNA complex with modelled p62 subunit | Descriptor: | DNA (49-MER), DNA repair protein complementing XP-A cells, General transcription and DNA repair factor IIH helicase subunit XPB, ... | Authors: | Koelmel, W, Kuper, J, Kisker, C. | Deposit date: | 2020-09-14 | Release date: | 2021-07-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair. Nucleic Acids Res., 48, 2020
|
|
5FMF
| the P-lobe of RNA polymerase II pre-initiation complex | Descriptor: | DNA REPAIR HELICASE RAD25, SSL2, DNA REPAIR HELICASE RAD3, ... | Authors: | Murakami, K, Tsai, K, Kalisman, N, Bushnell, D.A, Asturias, F.J, Kornberg, R.D. | Deposit date: | 2015-11-03 | Release date: | 2015-11-25 | Last modified: | 2017-07-12 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Structure of an RNA Polymerase II Pre-Initiation Complex Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
7ZSB
| |
7ZSA
| |
8GXS
| PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | Deposit date: | 2022-09-21 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
|
|
8GXQ
| PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | Deposit date: | 2022-09-21 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (5.04 Å) | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
|
|
7K04
| Structure of TFIIH/Rad4-Rad23-Rad33/DNA in DNA opening | Descriptor: | CALCIUM ION, DNA repair helicase RAD25, DNA repair helicase RAD3, ... | Authors: | van Eeuwen, T, Min, J.H, Murakami, K. | Deposit date: | 2020-09-03 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (9.25 Å) | Cite: | Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun, 12, 2021
|
|
7K01
| Structure of TFIIH in TFIIH/Rad4-Rad23-Rad33 DNA opening complex | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, General transcription and DNA repair factor IIH subunit SSL1, ... | Authors: | van Eeuwen, T, Min, J.H, Murakami, K. | Deposit date: | 2020-09-02 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun, 12, 2021
|
|
5OQJ
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | Deposit date: | 2017-08-11 | Release date: | 2018-04-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
|
|
6O9M
| Structure of the human apo TFIIH | Descriptor: | CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ... | Authors: | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | Deposit date: | 2019-03-14 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
|
|
5OQM
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | Deposit date: | 2017-08-13 | Release date: | 2018-05-09 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
|
|
6NMI
| Cryo-EM structure of the human TFIIH core complex | Descriptor: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, ... | Authors: | Greber, B.J, Toso, D, Fang, J, Nogales, E. | Deposit date: | 2019-01-10 | Release date: | 2019-03-13 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The complete structure of the human TFIIH core complex. Elife, 8, 2019
|
|
6O9L
| Human holo-PIC in the closed state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I. | Deposit date: | 2019-03-14 | Release date: | 2019-05-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nat.Struct.Mol.Biol., 26, 2019
|
|
5OF4
| The cryo-EM structure of human TFIIH | Descriptor: | General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4,p52,General transcription factor IIH subunit 4, ... | Authors: | Greber, B.J, Nguyen, T.H.D, Fang, J, Afonine, P.V, Adams, P.D, Nogales, E. | Deposit date: | 2017-07-10 | Release date: | 2017-09-13 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | The cryo-electron microscopy structure of human transcription factor IIH. Nature, 549, 2017
|
|
7ZS9
| |
8BVW
| RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Abril-Garrido, J, Dienemann, C, Grabbe, F, Velychko, T, Lidschreiber, M, Wang, H, Cramer, P. | Deposit date: | 2022-12-20 | Release date: | 2023-05-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of transcription reduction by a promoter-proximal +1 nucleosome. Mol.Cell, 83, 2023
|
|
7EGB
| TFIID-based holo PIC on SCP promoter | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | Deposit date: | 2021-03-24 | Release date: | 2021-05-05 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
|
|